A Study to Evaluate the Efficacy and Safety of Sefaxersen (RO7434656) in Participants With Primary Immunoglobulin A (IgA) Nephropathy at High Risk of Progression

PHASE3RecruitingINTERVENTIONAL
Enrollment

428

Participants

Timeline

Start Date

August 8, 2023

Primary Completion Date

August 31, 2026

Study Completion Date

March 31, 2029

Conditions
Primary IgA Nephropathy
Interventions
DRUG

Sefaxersen (RO7434656)

Sefaxersen (RO7434656) will be administered as SC injection per schedule as specified.

DRUG

Placebo

Matching placebo will be administered as SC injection per schedule as specified.

Trial Locations (188)

220

RECRUITING

Far Eastern Memorial Hospital, Taipei

333

RECRUITING

Chang Gung Memorial Hospital, Linkou, Taoyuan

500

RECRUITING

Changhua Christian Hospital, Changhua

2170

RECRUITING

Liverpool Hospital, Liverpool

2217

RECRUITING

St George Hospital, Kogarah

3021

RECRUITING

Sunshine Hospital, St Albans

3050

RECRUITING

Royal Melbourne Hospital, Parkville

4102

RECRUITING

Princess Alexandra Hospital, Woolloongabba

5000

RECRUITING

Sanatorio Mayo Privado, Córdoba

10154

RECRUITING

Ospedale San Giovanni Bosco, Turin

10449

RECRUITING

Mackay Memorial Hospital-Taipei branch, Zhongshan Dist.

11501

RECRUITING

NYU Langone Nephrology Associates - Mineola, Mineola

12808

RECRUITING

Vseobecna fakultni nemocnice v Praze, Prague

13496

RECRUITING

CHA Bundang Medical Center, CHA University, Seongnam-si

13620

RECRUITING

Seoul National University Bundang Hospital, Seongnam-si

14004

RECRUITING

C.H. Regional Reina Sofia - PPDS, Córdoba

14068

RECRUITING

Hallym University Sacred Heart Hospital, Anyang-si

14080

RECRUITING

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Barrio Belisario Domínguez Secc XVI

16132

RECRUITING

Ospedale Policlinico San Martino, Genoa

20129

RECRUITING

Clinica San Cosme, Fracc Lomas Del Campestre

22033

RECRUITING

Nephrology Associates of Northern Virginia Inc, Fairfax

22281

RECRUITING

Instituto D?Or Pesquisa e Ensino - Hospital Gloria D?Or, Rio de Janeiro

23298

RECRUITING

Virginia Commonwealth University, Richmond

25100

RECRUITING

Hospital Tengku Ampuan Afzan, Kuantan

25198

RECRUITING

Hospital Universitari Arnau de Vilanova, Lleida

27004

RECRUITING

Hospital Ribera Polusa, Lugo

27100

RECRUITING

IRCCS Pavia - Istituti Clinici Scientifici Maugeri Spa ? Società Benefit, Pavia

27609

RECRUITING

North Carolina Nephrology, PA, Raleigh

28041

RECRUITING

Hospital Universitario 12 De Octubre, Madrid

28046

RECRUITING

Hospital Universitario La Paz - PPDS, Madrid

28644

RECRUITING

Chungbuk National University Hospital, Cheongju-si

30101

RECRUITING

Cowry Medical Group LLC, Acworth

30150

RECRUITING

Freire Pesquisa Clinica, Belo Horizonte

30625

RECRUITING

Medizinische Hochschule Hannover, Hanover

31059

RECRUITING

Hôpital de Rangueil, Toulouse

32040

RECRUITING

Hospital Seri Manjung, Seri Manjong

33010

WITHDRAWN

Hope Clinic & Research Center, Hialeah

33126

RECRUITING

LCC Medical Research - Miami - ClinEdge - PPDS, Miami

33144

RECRUITING

L&C Professional Medical Research Institute, West Miami

34000

RECRUITING

Taiping Hospital, Taiping

35233

RECRUITING

UAB Nephrology Research Clinic, Birmingham

39216

RECRUITING

University of Mississippi Medical Center, Jackson

40138

RECRUITING

Azienda Ospedaliero Universitaria Di Bologna - Policlinico S Orsola Malpighi-Via Massarenti, Bologna

40447

RECRUITING

China Medical University Hospital, Taichung

40705

RECRUITING

Taichung Veterans General Hospital, Xitun Dist.

41013

RECRUITING

Hospital Universitario Virgen del Rocio - PPDS, Seville

43203

RECRUITING

Ohio State University Wexner Medical Center - Outpatient Care East, Columbus

45401

RECRUITING

Uniwersytecki Szpital Kliniczny w Opolu, Opole

50586

RECRUITING

Hospital Kuala Lumpur, Kuala Lumpur

51109

RECRUITING

Klinikum Koln-Merheim, Cologne

52074

RECRUITING

Universitatsklinikum der RWTH Aachen, Aachen

52242

RECRUITING

University of Iowa, Iowa City

53226

RECRUITING

Milwaukee Nephrologists, Sc, Wauwatosa

55101

RECRUITING

Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz

58260

RECRUITING

Centro de Investigacion Clinica Chapultepec S. A. de C. V., Morelia

59100

RECRUITING

University Malaya Medical Centre, Kuala Lumpur

60521

RECRUITING

Nephrology Associates of Northern Illinois, Hinsdale

62200

RECRUITING

CHU Boulogne sur Mer, Boulogne-sur-Mer

62448

RECRUITING

Instituto Mexicano de Trasplantes, Cuernavaca

64000

RECRUITING

Christus Latam Hub Center Of Excellence & Innovation, Monterrey

68000

RECRUITING

Hospital Ampang, Ampang

70124

RECRUITING

Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari, Bari

71110

RECRUITING

University General Hospital of Heraklion, Heraklion

75020

RECRUITING

Hopital Tenon, Paris

75092

RECRUITING

Revival Research Corporation - Sherman - ClinEdge - PPDS, Sherman

75224

WITHDRAWN

Global Medical Research - M3 WR, Dallas

75231

RECRUITING

Texas Kidney Institute - Dallas, Dallas

75877

RECRUITING

Hopital Bichat - Claude Bernard AP-HP, Paris

77054

RECRUITING

Prolato Clinical Research Center, Houston

77450

RECRUITING

R & H Clinical Research, Katy

80131

RECRUITING

Azienda Ospedaliera Universitaria Federico II, Napoli

83202

RECRUITING

Care Institute Idaho Kidney Institute, Chubbuck

83301

RECRUITING

Chang Gung Medical Foundation, Kaohsiung City

83402

RECRUITING

Care Institute Idaho Kidney Institute, Idaho Falls

84115

RECRUITING

Utah Kidney Research Institute, Salt Lake City

85710

WITHDRAWN

Tucson Neuroscience Research - M3 WR, Tucson

89511

RECRUITING

Sierra Nevada Nephrology Consultants, Reno

90022

RECRUITING

Academic Medical Research Institute - Los Angeles, Los Angeles

90623

WITHDRAWN

Southern California Medical Research Center, La Palma

91773

RECRUITING

North America Research Institute-San Dimas, San Dimas

94000

RECRUITING

Hopital Henri Mondor, Créteil

96000

RECRUITING

Hospital Sibu, Sibu

97471

WITHDRAWN

Kidney and Hypertension Center, Roseburg

98000

RECRUITING

Miri Hospital, Miri

100034

RECRUITING

Peking University First Hospital, Beijing

100044

RECRUITING

Peking University People's Hospital, Beijing

119074

RECRUITING

National University Hospital, Singapore

169608

RECRUITING

Singapore General Hospital, Singapore

200025

RECRUITING

Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai

210003

RECRUITING

The Second Affiliated Hospital of Nanjing Medical University, Nanjing

212001

RECRUITING

Affiliated Hospital of Jiangsu University, Zhenjiang

213003

RECRUITING

Changzhou First People's Hospital, Changzhou

215004

RECRUITING

The Second Affiliated Hospital of Soochow University, Suzhou

308433

RECRUITING

Tan Tock Seng Hospital, Singapore

310014

RECRUITING

Zhejiang Provincial People?s Hospital, Hangzhou

310016

RECRUITING

Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou

315000

RECRUITING

Ningbo No.2 Hospital, Ningbo

330000

RECRUITING

The First Affiliated Hospital of Nanchang University, Nanchang

330008

RECRUITING

The Second Affiliated Hospital of Nanchang University, Nanchang

430060

RECRUITING

Renmin Hospital of Wuhan University, Wuhan

510080

RECRUITING

Guangdong Provincial People's Hospital, Guangzhou

518020

RECRUITING

Shenzhen People's Hospital, Shenzhen

518053

RECRUITING

The University of Hong Kong - Shenzhen Hospital, Shenzhen

529889

RECRUITING

Changi General Hospital, Singapore

610072

RECRUITING

Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital, Chengdu

710061

RECRUITING

The First Affiliated Hospital of Xian Jiao Tong University, Xi'an

750004

RECRUITING

General Hospital of Ningxia Medical University, Yinchuan

999077

RECRUITING

Queen Mary Hospital, Hong Kong

85374-8644

RECRUITING

Sunrise Medical Management LLC, Surprise

91206-4032

RECRUITING

Kidney Disease Medical Group Inc-1505 Wilson Ter, Glendale

90025-4837

RECRUITING

University of California, Los Angeles (UCLA) - Hematology/Oncology Santa Monica, Los Angeles

02114

RECRUITING

Massachussets General Hospital, Boston

077099

RECRUITING

Pioneer Research Solutions, Houston

C1425AGC

RECRUITING

Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada, Ciudad Autonoma Buenos Aires

C1426ABP

RECRUITING

Consultorios Médicos Dr. Doreski, Ciudad Autonoma Buenos Aires

X5000JHQ

RECRUITING

Sanatorio Allende, Córdoba

S2013DTC

RECRUITING

Instituto Medico de la Fundacion Estudios Clinicos, Rosario

02747

RECRUITING

Nepean Hospital, Kingswood

SA5000

RECRUITING

Royal Adelaide Hospital, Adelaide

30150-221

RECRUITING

Santa Casa de Misericordia de Belo Horizonte - PPDS, Belo Horizonte

90035-903

RECRUITING

Hospital de Clinicas de Porto Alegre HCPA PPDS, Porto Alegre

89227-680

RECRUITING

Centro de Pesquisa Clinica da Fundação Pró Rim, Joinville

01246

RECRUITING

Faculdade de Medicina da Universidade de Sao Paulo, São Paulo

04038-002

RECRUITING

Hospital Do Rim E Hipertensao Fundacao Oswaldo Ramos, São Paulo

V5Z 1M9

RECRUITING

Vancouver General Hospital, Vancouver

B1P 1P3

RECRUITING

Cape Breton Regional Hospital, Sydney

N6A 5W9

RECRUITING

London Health Sciences Centre · Victoria Hospital, London

M4N 3M5

RECRUITING

Sunnybrook Health Sciences Centre, Toronto

H3G 1A4

RECRUITING

Montreal General Hospital, Montreal

G1R 2J6

RECRUITING

Centre Hospitalier Universitaire de Quebec, Québec

000000

RECRUITING

Beijing Friendship Hospital, Capital Medical University - PPDS, Beijing

050031

RECRUITING

The First Hospital of Hebei Medical University, Shijiazhuang

Unknown

RECRUITING

Xinhua Hospital Affiliated To Shanghai Jiaotong University School of Medicine, Shanghai

500 05

RECRUITING

Fakultni nemocnice Hradec Kralove, Hradec Králové

07103

RECRUITING

Centre Hospitalier, Annonay

714 09

RECRUITING

Venizeleio General Hospital of Heraklion, Heraklion

265 04

RECRUITING

University General Hospital of Patras, Pátrai

546 42

WITHDRAWN

Ippokratio General Hospital of Thessaloniki, Thessaloniki

00168

RECRUITING

Fondazione Policlinico Universitario A Gemelli, Rome

470-1192

RECRUITING

Fujita Health University Hospital, Aichi

036-8563

RECRUITING

Hirosaki University Hospital, Aomori

279-0021

RECRUITING

Juntendo University Urayasu Hospital, Chiba

409-3821

RECRUITING

University of Yamanashi Hospital, Chūō

790-8524

RECRUITING

Matsuyama Red Cross Hospital, Ehime

815-8555

RECRUITING

Japanese Red Cross Fukuoka Hospital, Fukuoka

734-8551

RECRUITING

Hiroshima University Hospital, Hiroshima

060-8648

RECRUITING

Hokkaido University Hospital, Hokkaido

300-0395

RECRUITING

Tokyo Medical University Ibaraki Medical Center, Inashiki-Gun

920-0293

RECRUITING

Kanazawa Medical University Hospital, Ishikawa

634-8522

RECRUITING

Nara Medical University Hospital, Kashihara

860-8556

RECRUITING

Kumamoto University Hospital, Kumamoto

980-8574

RECRUITING

Tohoku University Hospital, Miyagi

604-8845

RECRUITING

Kyoto City Hospital, Nakagyo-ku

630-8054

RECRUITING

Nara Prefecture General Medical Center, Nara

662-0918

RECRUITING

Hyogo Prefectural Nishinomiya Hospital, Nishinomiya

028-3695

RECRUITING

Iwate Medical University Hospital, Numakunai

701-1192

RECRUITING

National Hospital Organization Okayama Medical Center, Okayama

700-0914

RECRUITING

Okayama University Hospital, Okayama-Shi Kita-Ku

903-0125

RECRUITING

University of the Ryukyus Hospital, Okinawa

350-0451

RECRUITING

Saitama Medical University Hospital, Saitama

565-0871

RECRUITING

Osaka University Hospital, Suita

329-0498

RECRUITING

Jichi Medical University Hospital, Tochigi

770-8503

RECRUITING

Tokushima University Hospital, Tokushima

105-8471

RECRUITING

The Jikei University Hospital, Tokyo

113-8431

RECRUITING

Juntendo University Hospital, Tokyo

162-8666

RECRUITING

Tokyo Women's Medical University Hospital, Tokyo

177-8521

RECRUITING

Juntendo University Nerima Hospital, department of renal and hypertension, Tokyo

305-8576

RECRUITING

University of Tsukuba Hospital, Tsukuba

755-8505

RECRUITING

Yamaguchi University Hospital, Ube

31-559

RECRUITING

SCM Clinic - Prywatny Szpital Specjalistyczny, Krakow

92-213

RECRUITING

SPZOZ Centralny Szpital Klin, Lodz

60-355

RECRUITING

Szpital Kliniczny im. H.Swiecickiego UM w Poznaniu, Późna

02-006

RECRUITING

Szpital Kliniczny Dzieciatka Jezus, Warsaw

50-556

RECRUITING

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza Radeckiego we Wroclawiu, Wroc?aw

420-767

RECRUITING

Soon Chun Hyang University Hospital Bucheon, Bucheon-si

443-380

RECRUITING

Ajou University Hospital, Gyeonggi-do

03080

RECRUITING

Seoul National University Hospital, Seoul

05030

RECRUITING

Konkuk University Medical Center, Seoul

05278

RECRUITING

Gangdong Kyung Hee University Hospital, Seoul

06351

RECRUITING

Samsung Medical Center, Seoul

156-707

RECRUITING

SMG-SNU Boramae Medical Center, Seoul

08035

RECRUITING

Hospital Universitario Vall d'Hebron - PPDS, Barcelona

CB2 0QQ

RECRUITING

Addenbrookes Hospital, Cambridge

LE5 4PW

RECRUITING

Leicester General Hospital, Leicester

SE1 9RT

RECRUITING

Guys and St Thomas Hospital, London

SE5 9RS

RECRUITING

Kings College Hospital, London

OX3 7LE

RECRUITING

Churchill Hospital, Oxford

M6 8HD

RECRUITING

Salford Royal Hospital, Salford

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY