Postoperation Maintenance Therapy for Resectable Liver Metastases of Colorectal Cancer Guided by ctDNA

PHASE3RecruitingINTERVENTIONAL
Enrollment

346

Participants

Timeline

Start Date

February 20, 2023

Primary Completion Date

February 20, 2029

Study Completion Date

February 20, 2031

Conditions
Colorectal CancerLiver MetastasesCirculating Tumor CellCancer, Therapy-Related
Interventions
PROCEDURE

Colorectal resection surgery.

Colorectal cancer radical resection combined with liver metastasis resection or ablation.

DRUG

FOLFOX chemotherapy regimen

Chemotherapy regimens recommended include oxaliplatin-based CapeOx or FOLFOX regimens, or single-agent 5-FU/LV, capecitabine, or combination with targeted therapy.

DRUG

Capecitabine

Maintenance therapy is recommended to be continued with low-toxicity drugs such as 5-FU/LV or capecitabine, and may be combined with targeted therapy. Treatment should be discontinued once ctDNA testing is negative.

Trial Locations (1)

Unknown

RECRUITING

The Sixth Affiliate Hospital of Sun Yat-Sen University, Guangzhou

All Listed Sponsors
lead

Sixth Affiliated Hospital, Sun Yat-sen University

OTHER