NCT05795478View on ClinicalTrials.gov

Effects of Oxycodone Combined With Pregabalin on Chronic Postsurgical Pain in Spinal Surgery

NARecruitingINTERVENTIONAL
Enrollment

264

Participants

Timeline

Start Date

October 24, 2023

Primary Completion Date

December 31, 2024

Study Completion Date

December 31, 2024

Conditions
Chronic Post Operative PainOxycodonePregabalinPostoperative Complications
Interventions
DRUG

Oxycodone and Pregabalin

Oxycodone: 150mg PCIA during 3 days postoperatively Pregabalin: 150mg preoperatvely, 75mg BID for POD1\~7,75mg QD for POD8\~14

DRUG

Oxycodone and placebo capsules

Oxycodone: 150mg PCIA for 3 days postoperatively placebo capsules: same numbers as pregabalin at each time point

DRUG

Pregabalin and NS

Pregabalin: 150mg preoperatively, 75mg BID for POD1\~7,75mg QD for POD8\~14 NS: Equal volume NS for 3 days postoperatively

DRUG

placebo capsules and NS

placebo capsules: same numbers as pregabalin at each time point NS: Equal volume NS for 3 days postoperatively

Trial Locations (1)

100070

RECRUITING

Beijing Tiantan Hospital, Beijing

All Listed Sponsors
lead

Beijing Tiantan Hospital

OTHER