Venetoclax Treatment (26 Cycles) With 6 Cycles or 12 Cycles of Epcoritamab in Patients With Relapsed or Refractory CLL or SLL

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

112

Participants

Timeline

Start Date

April 10, 2024

Primary Completion Date

March 31, 2029

Study Completion Date

November 30, 2032

Conditions
CLL/SLL
Interventions
DRUG

Epcoritamab

Number of cycles of epcoritamab is either 6 (cycle 1-6) or 12 (cycle 1-12). Patients will be treated until they have received the total number of assigned treatment cycles or until progression, or severe toxicity, whichever comes first.

DRUG

Venetoclax

All patients will receive venetoclax cycle 1-26 (a 5 week ramp-up of venetoclax will precede the first cycle). Patients will be treated until they have received the total number of assigned treatment cycles or until progression, or severe toxicity, whichever comes first.

Trial Locations (24)

Unknown

NOT_YET_RECRUITING

BE-Antwerpen-ZNASTUIVENBERG, Antwerp

NOT_YET_RECRUITING

BE-Roeselare-AZDELTA, Roeselare

NOT_YET_RECRUITING

DK-Aalborg-ALBOGUH, Aalborg

RECRUITING

DK-Copenhagen-RIGSHOSPITALET, Copenhagen

NOT_YET_RECRUITING

DK-Odense-OUH, Odense

NOT_YET_RECRUITING

DE-Berlin-HELIOSBERLINBUCH, Berlin

NOT_YET_RECRUITING

DE-Köln-UKKOELN, Cologne

NOT_YET_RECRUITING

DE-Freiburg-UNIKLINIKFREIBURG, Freiburg im Breisgau

NOT_YET_RECRUITING

DE-Greifswald-UNIGREIFSWALD, Greifswald

NOT_YET_RECRUITING

DE-Munster-GEMEINSCHAFTSPRAXIS, Münster

NOT_YET_RECRUITING

DE-Stuttgart-RBK, Stuttgart

NOT_YET_RECRUITING

DE-Ulm-UNIKLINKULM, Ulm

NOT_YET_RECRUITING

NL-Den Bosch-JBZ, 's-Hertogenbosch

NOT_YET_RECRUITING

NL-Alkmaar-NWZ, Alkmaar

NOT_YET_RECRUITING

NL-Amersfoort-MEANDERMC, Amersfoort

NOT_YET_RECRUITING

NL-Amsterdam-AMC, Amsterdam

NOT_YET_RECRUITING

NL-Dordrecht-ASZ, Dordrecht

NOT_YET_RECRUITING

NL-Ede-ZGV, Ede

NOT_YET_RECRUITING

NL-Eindhoven-CATHARINA, Eindhoven

NOT_YET_RECRUITING

NL-Groningen-UMCG, Groningen

NOT_YET_RECRUITING

NL-Leeuwarden-MCL, Leeuwarden

NOT_YET_RECRUITING

NL-Den Haag-HAGA, The Hague

NOT_YET_RECRUITING

NL-Tilburg-ETZ, Tilburg

NOT_YET_RECRUITING

NL-Utrecht-UMCUTRECHT, Utrecht

All Listed Sponsors
collaborator

Nordic CLL Study Group

UNKNOWN

collaborator

German CLL Study Group

OTHER

lead

Stichting Hemato-Oncologie voor Volwassenen Nederland

OTHER