MVA to Improve the Pregnancy Outcome in Aged Infertility Women With Assisted Reproductive Technology

NARecruitingINTERVENTIONAL
Enrollment

148

Participants

Timeline

Start Date

October 8, 2022

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Infertility, FemaleIVFReproductive DisorderOocyte
Interventions
DIETARY_SUPPLEMENT

Mevalproic acid

Methovalerate pathway is a metabolism of cholesterol and isoprenoid synthesized from acetyl coenzyme A Pathway, which plays a key role in human health and disease, is also necessary for human cells to maintain normal functions. There are a series of important metabolic intermediates in the mevalproate pathway, such as farnesyl diphosphate and incense Folyl vanillin diphosphates, which modify proteins through isoprene, play an important role in regulating cell function. In addition, the latest research shows that valproic acid, the key metabolic intermediate of valproic acid pathway, being the synthetic precursor of cholesterol and isoprene, it can activate insulin growth factor (IGF)1-R and mTOR signals and maintain cell function by mediating histone function

Trial Locations (1)

210008

RECRUITING

Reproductive Medicine Center, The affiliated Drum Towel Hospital of Nanjing University Medical School, Nanjing

All Listed Sponsors
lead

Nanjing University

OTHER