30
Participants
Start Date
March 7, 2023
Primary Completion Date
October 31, 2029
Study Completion Date
October 31, 2029
Trastuzumab
An initial loading dose of 8 mg/kg body weight, followed thereafter by a maintenance dose of 6 mg/kg body weight administered intravenously every 21 days. Patients may continue until disease progression without clinical benefit, unacceptable toxicity or withdrawal of consent.
Pertuzumab
An initial loading dose of 640 mg, followed thereafter by a maintenance dose of 420 mg administered intravenously every 21 days. Paediatric patients will receive an initial loading dose of 14 mg/kg (maximum 840 mg), followed thereafter by a maintenance dose of 7 mg/kg (maximum 420 mg) administered intravenously every 21 days. Patients may continue until disease progression without clinical benefit, unacceptable toxicity or withdrawal of consent.
RECRUITING
Belfast City Hospital, Belfast
RECRUITING
University Hospital Birmingham, Birmingham
NOT_YET_RECRUITING
Birmingham Children's Hospital, Birmingham
RECRUITING
Bristol Royal Hospital for Children, Bristol
RECRUITING
Bristol Haematology and Oncology Centre, Bristol
RECRUITING
Addenbrooke's Hospital, Cambridge
RECRUITING
Velindre Cancer Centre, Cardiff
NOT_YET_RECRUITING
Cardiff Children's Hospital, Cardiff
RECRUITING
Western General Hospital, Edinburgh
RECRUITING
The Beatson Hospital, Glasgow
RECRUITING
Royal Hospital for Children Glasgow, Glasgow
RECRUITING
Leicester Royal Infirmary, Leicester
RECRUITING
Alder Hey Hospital, Liverpool
RECRUITING
University College London Hospital, London
RECRUITING
Guy's Hospital, London
RECRUITING
Great Ormond Street Hospital, London
NOT_YET_RECRUITING
Royal Manchester Children's Hospital, Manchester
RECRUITING
The Christie Hospital, Manchester
RECRUITING
Clatterbridge Cancer Centre, Metropolitan Borough of Wirral
RECRUITING
Great North Children's Hospital, Newcastle
RECRUITING
Freeman Hospital, Newcastle
RECRUITING
Churchill Hospital, Oxford
RECRUITING
John Radcliffe Hospital, Oxford
RECRUITING
Weston Park Hospital, Sheffield
RECRUITING
Sheffield's Children's Hospital, Sheffield
RECRUITING
Southampton General Hospital, Southampton
RECRUITING
The Royal Marsden Hospital, Sutton
Lead Sponsor
University of Manchester
OTHER
University of Birmingham
OTHER
Royal Marsden NHS Foundation Trust
OTHER
Hoffmann-La Roche
INDUSTRY
Cancer Research UK
OTHER