PF-07304814 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)

PHASE3TerminatedINTERVENTIONAL
Enrollment

58

Participants

Timeline

Start Date

September 15, 2021

Primary Completion Date

April 6, 2022

Study Completion Date

July 14, 2023

Conditions
COVID-19
Interventions
DRUG

PF-07304814

PF-07304814 is a phosphate ester prodrug of PF-00835231 (active moiety), a potent and selective inhibitor of the SARS-CoV-2 3CLpro.

DRUG

Placebo

Commercially available 0.9% sodium chloride solution

BIOLOGICAL

Remdesivir

Antiviral agent

Trial Locations (40)

2100

Righospitalet (Site 625-006), Blegdamsvej 9,, Copenhagen Ø

2400

Bispebjerg Hospital (Site 625-013), Bispebjerg Bakke 23, Copenhagen

2730

Herlev/Gentofte Hospital (Site 625-012), Medicinsk Afdeling, Herlev Ringvej 75, Herlev

3400

Nordsjællands Hospital (Site 625-009), Dyrehavevej 29, Hillerød

4000

Zealand University Hospital, Roskilde (Site 625-010), Sygehusvej 10, Roskilde

5000

Odense University Hospital (Site 625-004), Infektionsmedicinsk Forskningsenhed, J.B. Winsløwsgade 4, Odense

6000

Kolding Sygehus (Site 625-011), Medicinsk Afdeling, Sygehusvej 24, Kolding

8200

Aarhus Universitetshospital, Skejby (Site 625-002), Department of Infectious Diseases, Palle Juul-Hensens Boulevard 99, Aarhus N

9000

Aalborg Hospital (Site 625-005), Hobrovej 18, Aalborg

20010

MedStar Health Research Institute (Site 009-021), MedStar Washington Hospital Center, 110 Irving St., NW., Washington D.C.

26506

West Virginia University (Site 301-023), One Medical Center Drive, Morgantown

27710

Duke University Hospital (Site 301-006), 2301 Erwin Road, Durham

29401

Ralph H. Johnson VA Medical Center (Site 074-015), 109 Bee Street, Charleston

29425

MUSC Research Nexus Clinic (Site 210-002), 96 Jonathan Lucas St., CSB 214, Charleston

29505

MUSC Health Florence Medical Center (Site 210-006), 805 Pamplico Highway, Florence

33602

Hillsborough County Health Department, University of South Florida (Site 032-001), Tampa

33744

Bay Pines VAMC (Site 074-004), 10000 Bay Pines Blvd., Bldg. 100, Room 5B-104, Bay Pines

46804

Lutheran Medical Group (Site 301-010), 7916 W. Jefferson Boulevard, Fort Wayne

48202

Henry Ford Health System, Henry Ford Hospital (Site 014-001), 2799 W. Grand Blvd., Detroit

70121

Ochsner Clinic Foundation (Site 301-015), 1514 Jefferson Highway, New Orleans

75235

Parkland Health and Hospital Systems (Site 084-002), 5200 Harry Hines Blvd, Dallas

UT Southwestern Medical Center (Site 084-001), 1936 Amelia Court, 2nd Floor, Dallas

75246

Baylor, Scott and White Health (Site 301-003), Baylor University Medical Center, 3500 Gaston Ave., Dallas

80206

National Jewish Health / St. Joseph Hospital (Site 204-003), 1400 Jackson Street, Denver

84108

University of Utah Hospital (Site 211-002), 419 Wakara Way, Suite 207, Salt Lake City

90048

Cedars-Sinai Medical Center (Site 208-002), 8700 Beverly Blvd., Los Angeles

91911

Velocity Chula Vista (Site 080-034), 752 Medical Center Ct., Ste. 304, Chula Vista

92161

VA San Diego Healthcare System (Site 074-016), 3350 La Jolla Village Drive, San Diego

92663

Hoag Memorial Hospital Presbyterian (Site 080-026), One Hoag Drive, Newport Beach

94121

San Francisco VAMC (Site 074-002), 4150 Clement St., San Francisco

94304

Palo Alto VAMC (Site 074-005), 3801 Miranda Avenue, Palo Alto

95655

Sacramento VA Medical Center (Site 074-023), 10535 Hospital Way, Mather

95817

UC Davis Health (Site 203-004), 2315 Stockton Blvd., Sacramento

97239

Portland VA Healthcare System (Site 074-024), 3710 SW. US Veterans Hospital Road, Portland

06516

West Haven VA Medical Center (Site 025-007), 950 Campbell Avenue, West Haven

02114

Massachusetts General Hospital (Site 202-002), 55 Fruit Street, Boston

02215

Beth Israel Deaconess Medical Center (Site 202-001), 330 Brookline Ave., Boston

03756

Dartmouth-Hitchcock Medical Center/Mary Hitchcock Memorial Hospital (Site 301-024), One Medical Center Drive, Lebanon

02903

Rhode Island Hospital (Site 080-036), 593 Eddy Street, Providence

02906

The Miriam Hospital (Site 080-039), 164 Summit Ave., Providence

All Listed Sponsors
collaborator

International Network for Strategic Initiatives in Global HIV Trials (INSIGHT)

NETWORK

collaborator

University of Copenhagen

OTHER

collaborator

Medical Research Council

OTHER_GOV

collaborator

Kirby Institute

OTHER_GOV

collaborator

Washington D.C. Veterans Affairs Medical Center

FED

collaborator

Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

NETWORK

collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

US Department of Veterans Affairs

FED

collaborator

Prevention and Early Treatment of Acute Lung Injury

OTHER

collaborator

Cardiothoracic Surgical Trials Network

OTHER

collaborator

Pfizer

INDUSTRY

collaborator

University of Minnesota

OTHER

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

NCT05780541 - PF-07304814 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial) | Biotech Hunter | Biotech Hunter