58
Participants
Start Date
September 15, 2021
Primary Completion Date
April 6, 2022
Study Completion Date
July 14, 2023
PF-07304814
PF-07304814 is a phosphate ester prodrug of PF-00835231 (active moiety), a potent and selective inhibitor of the SARS-CoV-2 3CLpro.
Placebo
Commercially available 0.9% sodium chloride solution
Remdesivir
Antiviral agent
Righospitalet (Site 625-006), Blegdamsvej 9,, Copenhagen Ø
Bispebjerg Hospital (Site 625-013), Bispebjerg Bakke 23, Copenhagen
Herlev/Gentofte Hospital (Site 625-012), Medicinsk Afdeling, Herlev Ringvej 75, Herlev
Nordsjællands Hospital (Site 625-009), Dyrehavevej 29, Hillerød
Zealand University Hospital, Roskilde (Site 625-010), Sygehusvej 10, Roskilde
Odense University Hospital (Site 625-004), Infektionsmedicinsk Forskningsenhed, J.B. Winsløwsgade 4, Odense
Kolding Sygehus (Site 625-011), Medicinsk Afdeling, Sygehusvej 24, Kolding
Aarhus Universitetshospital, Skejby (Site 625-002), Department of Infectious Diseases, Palle Juul-Hensens Boulevard 99, Aarhus N
Aalborg Hospital (Site 625-005), Hobrovej 18, Aalborg
MedStar Health Research Institute (Site 009-021), MedStar Washington Hospital Center, 110 Irving St., NW., Washington D.C.
West Virginia University (Site 301-023), One Medical Center Drive, Morgantown
Duke University Hospital (Site 301-006), 2301 Erwin Road, Durham
Ralph H. Johnson VA Medical Center (Site 074-015), 109 Bee Street, Charleston
MUSC Research Nexus Clinic (Site 210-002), 96 Jonathan Lucas St., CSB 214, Charleston
MUSC Health Florence Medical Center (Site 210-006), 805 Pamplico Highway, Florence
Hillsborough County Health Department, University of South Florida (Site 032-001), Tampa
Bay Pines VAMC (Site 074-004), 10000 Bay Pines Blvd., Bldg. 100, Room 5B-104, Bay Pines
Lutheran Medical Group (Site 301-010), 7916 W. Jefferson Boulevard, Fort Wayne
Henry Ford Health System, Henry Ford Hospital (Site 014-001), 2799 W. Grand Blvd., Detroit
Ochsner Clinic Foundation (Site 301-015), 1514 Jefferson Highway, New Orleans
Parkland Health and Hospital Systems (Site 084-002), 5200 Harry Hines Blvd, Dallas
UT Southwestern Medical Center (Site 084-001), 1936 Amelia Court, 2nd Floor, Dallas
Baylor, Scott and White Health (Site 301-003), Baylor University Medical Center, 3500 Gaston Ave., Dallas
National Jewish Health / St. Joseph Hospital (Site 204-003), 1400 Jackson Street, Denver
University of Utah Hospital (Site 211-002), 419 Wakara Way, Suite 207, Salt Lake City
Cedars-Sinai Medical Center (Site 208-002), 8700 Beverly Blvd., Los Angeles
Velocity Chula Vista (Site 080-034), 752 Medical Center Ct., Ste. 304, Chula Vista
VA San Diego Healthcare System (Site 074-016), 3350 La Jolla Village Drive, San Diego
Hoag Memorial Hospital Presbyterian (Site 080-026), One Hoag Drive, Newport Beach
San Francisco VAMC (Site 074-002), 4150 Clement St., San Francisco
Palo Alto VAMC (Site 074-005), 3801 Miranda Avenue, Palo Alto
Sacramento VA Medical Center (Site 074-023), 10535 Hospital Way, Mather
UC Davis Health (Site 203-004), 2315 Stockton Blvd., Sacramento
Portland VA Healthcare System (Site 074-024), 3710 SW. US Veterans Hospital Road, Portland
West Haven VA Medical Center (Site 025-007), 950 Campbell Avenue, West Haven
Massachusetts General Hospital (Site 202-002), 55 Fruit Street, Boston
Beth Israel Deaconess Medical Center (Site 202-001), 330 Brookline Ave., Boston
Dartmouth-Hitchcock Medical Center/Mary Hitchcock Memorial Hospital (Site 301-024), One Medical Center Drive, Lebanon
Rhode Island Hospital (Site 080-036), 593 Eddy Street, Providence
The Miriam Hospital (Site 080-039), 164 Summit Ave., Providence
Collaborators (3)
International Network for Strategic Initiatives in Global HIV Trials (INSIGHT)
NETWORK
University of Copenhagen
OTHER
Medical Research Council
OTHER_GOV
Kirby Institute
OTHER_GOV
Washington D.C. Veterans Affairs Medical Center
FED
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
NETWORK
National Heart, Lung, and Blood Institute (NHLBI)
NIH
US Department of Veterans Affairs
FED
Prevention and Early Treatment of Acute Lung Injury
OTHER
Cardiothoracic Surgical Trials Network
OTHER
Pfizer
INDUSTRY
University of Minnesota
OTHER
National Institute of Allergy and Infectious Diseases (NIAID)
NIH