1,455
Participants
Start Date
February 10, 2021
Primary Completion Date
January 28, 2022
Study Completion Date
June 9, 2023
AZD7442
AZD8895 and AZD1061, known collectively as AZD7442, are two fully human neutralizing immunoglobulin G (IgG)-1 kappa monoclonal antibodies (mAb) that target two distinct epitopes on the receptor-binding domain of the spike protein of SARS-CoV- 2.
Placebo
Commercially available 0.9% sodium chloride solution
Remdesivir
Antiviral agent
Righospitalet (Site 625-006), Blegdamsvej 9,, Copenhagen Ø
Bispebjerg Hospital (Site 625-013), Bispebjerg Bakke 23, Copenhagen
Hvidovre University Hospital, Department of Infectious Diseases (Site 625-001), Kettegård allé 30, Hvidovre
Herlev/Gentofte Hospital (Site 625-012), Medicinsk Afdeling, Herlev Ringvej 75, Herlev
Nordsjællands Hospital (Site 625-009), Dyrehavevej 29, Hillerød
Zealand University Hospital, Roskilde (Site 625-010), Sygehusvej 10, Roskilde
Odense University Hospital (Site 625-004), Infektionsmedicinsk Forskningsenhed, J.B. Winsløwsgade 4, Odense
Kolding Sygehus (Site 625-011), Medicinsk Afdeling, Sygehusvej 24, Kolding
University Hospital Zurich (Site 621-201), Department of Infectious Diseases and Hospital Epidemiology, Raemistrasse 100, Zurich
Aarhus Universitetshospital, Skejby (Site 625-002), Department of Infectious Diseases, Palle Juul-Hensens Boulevard 99, Aarhus N
Aalborg Hospital (Site 625-005), Hobrovej 18, Aalborg
Lincoln Medical Center (New York Health and Hospitals/Lincoln) (Site 003-016), 234 E. 149th Street, The Bronx
Montefiore Medical Center Weiler Hospital (Site 206-003), 1825 Eastchester Road, The Bronx
Montefiore Medical Center Moses Hospital (Site 206-001), 111 E. 210th Street, The Bronx
SUNY Downstate Medical Center (Site 033-001), 450 Clarkson Ave., Brooklyn
Maimonides Medical Center (Site 033-002), 4802 10th Avenue, Brooklyn
UPMC Magee-Womens Hospital (Site 209-003), 300 Halket Street, Pittsburgh
UPMC Presbyterian Hospital (Site 209-001), 200 Lothrop Street, Pittsburgh
UPMC Shadyside Hospital (Site 209-005), 5230 Centre Avenue, Pittsburgh
MedStar Health Research Institute (Site 009-021), MedStar Washington Hospital Center, 110 Irving St., NW., Washington D.C.
Washington DC VA Medical Center (Site 009-004), 50 Irving Street NW, Washington D.C.
University of Maryland Medical Center (Site 301-019), 22 South Greene Street, Baltimore
University of Virginia Health Systems (Site 301-021), 1215 Lee Street, Charlottesville
Carilion Roanoke Memorial Hospital (Site 080-018), 1906 Belleview Avenue, Roanoke
Salem VA Medical Center (Site 074-014), 1970 Roanoke Blvd., Salem
Hospital Universitari Arnau de Vilanova (Site 626-035), Av. Alcalde Rovira Roure 80, Lleida
West Virginia University (Site 301-023), One Medical Center Drive, Morgantown
Wake Forest University Health Sciences (Site 210-001), Medical Center Blvd, Winston-Salem
Duke University Hospital (Site 301-006), 2301 Erwin Road, Durham
Hospital General Universitario Gregorio Marañón (Site 626-001), Dr. Esquerdo, 46, Madrid
Hospital Clínico San Carlos (Site 626-017), Enfermedades infecciosas, C/Martin Lagos CN, Madrid
UCICEC (Clinical Trial Unit) Hospital Universitario La Paz (Site 626-012), Paseo de la Castellana 261, 2a planta Hospital Maternal, Madrid
Ralph H. Johnson VA Medical Center (Site 074-015), 109 Bee Street, Charleston
MUSC Research Nexus Clinic (Site 210-002), 96 Jonathan Lucas St., CSB 214, Charleston
MUSC Health Florence Medical Center (Site 210-006), 805 Pamplico Highway, Florence
Emory University (Site 301-008), The Emory Clinic, Bldg. A, Suite 2236, 1365 Clifton Rd., NE, Atlanta
Memorial Healthcare System (Site 648-002), Memorial Regional Hospital, 3501 Johnson Street, Hollywood
Miami VAMC (Site 074-003), 1201 NW 16 Street, Miami
Hillsborough County Health Department, University of South Florida (Site 032-001), Tampa
Bay Pines VAMC (Site 074-004), 10000 Bay Pines Blvd., Bldg. 100, Room 5B-104, Bay Pines
Baycare Health System (Site 301-025), Morton Plant Hospital, 300 Pinellas Street, Clearwater
VA TVHS Nashville Campus (Site 074-022), 1310 24th Avenue South, Nashville
Vanderbilt University Medical Center (Site 212-001), 1211 Medical Center Drive, Nashville
University of Mississippi Medical Center (Site 202-005), 2500 North State Street, Jackson
University of Kentucky Hospital (Site 210-004), 1000 South Limestone St., Lexington
University Hospitals Cleveland Medical Center (Site 108-001), 11100 Euclid Avenue, Cleveland
Cleveland Clinic Fairview Hospital (Site 207-005), 18101 Lorain Avenue, Cleveland
Cleveland Clinic Marymount Hospital (Site 207-006), 12300 McCraken Road, Garfield Heights
Cleveland Clinic Foundation (Site 207-001), 9500 Euclid Avenue, Cleveland
University of Cincinnati Medical Center (Site 207-003), 234 Goodman Ave., Cincinnati
Lutheran Medical Group (Site 301-010), 7916 W. Jefferson Boulevard, Fort Wayne
University of Michigan (Site 205-001), 1500 East Medical Center Drive, Ann Arbor
Henry Ford Health System, Henry Ford Hospital (Site 014-001), 2799 W. Grand Blvd., Detroit
Minneapolis Heart Institute Foundation (Site 301-026), Abbott Northwestern Hospital, 920 E 28th St. #100, Minneapolis
Hennepin Healthcare (Site 027-001), 701 Park Avenue, Minneapolis
Minneapolis VA Health Care System (Site 105-001), 1 Veterans Drive, Bldg 70, Minneapolis
M Health Fairview University of Minnesota Medical Center (Site 112-001), 500 Harvard St. SE., Minneapolis
Cotton O'Neil Clinical Research Center (Site 080-030), Stormont Vail Health, 1500 SW 10th Avenue, Topeka
Democritus University of Thrace (Site 635-021), University General Hospital of Alexandroupolis, Dragana, Alexandroupoli
Ochsner Clinic Foundation (Site 301-015), 1514 Jefferson Highway, New Orleans
Parkland Health and Hospital Systems (Site 084-002), 5200 Harry Hines Blvd, Dallas
UT Southwestern Medical Center (Site 084-001), 1936 Amelia Court, 2nd Floor, Dallas
Baylor, Scott and White Health (Site 301-003), Baylor University Medical Center, 3500 Gaston Ave., Dallas
CHRISTUS Good Shepherd Medical Center (Site 080-031), 700 E. Marshall Ave., Longview
Michael E. DeBakey Veterans Affairs Medical Center (MEDV AMC) (Site 074-006), 2002 Holcombe Blvd., Houston
Texas Heart Institute (Site 301-017), 6770 Bertner, MC4-266, Houston
CHRISTUS Spohn Shoreline Hospital (Site 080-001), 600 Elizabeth Street, Corpus Christi
Hendrick Medical Center (Site 080-014), 1900 Pine Street, Abilene
University of Colorado Hospital (Site 204-001), 12605 E. 16th Avenue, Aurora
Denver Public Health (Site 017-004), 660 Bannock St., MC2600 (Infectious Disease Clinic), Denver
National Jewish Health / St. Joseph Hospital (Site 204-003), 1400 Jackson Street, Denver
Intermountain Medical Center (Site 211-001), 5121 South Cottonwood Street, Murray
University of Utah Hospital (Site 211-002), 419 Wakara Way, Suite 207, Salt Lake City
LDS Hospital (Site 211-004), 8th Ave. C Street, Salt Lake City
Banner University Medical Center Tucson (Site 206-004), 1625 N. Campbell Avenue, Tucson
Southern Arizona VA Healthcare System (Site 074-009), 3601 S. 6th Ave., Tucson
Keck Hospital of USC (Site 301-020), 1500 San Pablo Street, Los Angeles
Cedars-Sinai Medical Center (Site 208-002), 8700 Beverly Blvd., Los Angeles
Ronald Reagan UCLA Medical Center (Site 203-002), 757 Westwood Plaza, Los Angeles
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (Site 066-002), 1124 W. Carson Street, CDCRC Building, Torrance
VA Long Beach Healthcare System (Site 074-026), 5901 East 7th Street (09/151-M2), Long Beach
Velocity Chula Vista (Site 080-034), 752 Medical Center Ct., Ste. 304, Chula Vista
Velocity San Diego (Site 080-035), 5565 Grossmont Center Drive, Building 2, Suite 1, La Mesa
VA San Diego Healthcare System (Site 074-016), 3350 La Jolla Village Drive, San Diego
VA Loma Linda Healthcare System (Site 074-017), 11201 Benton Street, Loma Linda
Hoag Memorial Hospital Presbyterian (Site 080-026), One Hoag Drive, Newport Beach
Community Regional Medical Center (Site 203-005), 2823 Fresno Street, Fresno
UCSF Medical Center at Mount Zion (Site 203-007), 1600 Divisadero St., San Francisco
San Francisco VAMC (Site 074-002), 4150 Clement St., San Francisco
UCSF Medical Center (Site 203-001), Moffitt-Long Hospital, 505 Parnassus Ave., San Francisco
Stanford University Hospital & Clinics (Site 203-003), 300 Pasteur Dr., Stanford
Sacramento VA Medical Center (Site 074-023), 10535 Hospital Way, Mather
Swedish Hospital First Hill (Site 208-005), 747 Broadway, Seattle
Tan Tock Seng Hospital (Site 612-201), National Centre for Infectious Diseases (NCID), 11 Jalan Tan Tock Seng, Singapore
West Haven VA Medical Center (Site 025-007), 950 Campbell Avenue, West Haven
North Florida/South Georgia Veterans Health System (Site 074-011), 1601 SW. Archer Road, Gainesville
Massachusetts General Hospital (Site 202-002), 55 Fruit Street, Boston
Beth Israel Deaconess Medical Center (Site 202-001), 330 Brookline Ave., Boston
Baystate Medical Center (Site 201-001), 759 Chestnut Street, Springfield
Dartmouth-Hitchcock Medical Center/Mary Hitchcock Memorial Hospital (Site 301-024), One Medical Center Drive, Lebanon
Cooper University Hospital (Site 019-001), One Cooper Plaza, Camden
Oregon Health & Science University (Site 208-003), 3181 SW Sam Jackson Park Rd., Portland
Rhode Island Hospital (Site 080-036), 593 Eddy Street, Providence
The Miriam Hospital (Site 080-039), 164 Summit Ave., Providence
VA Providence Healthcare System (Site 074-025), 830 Chalkstone Ave., Providence
Evangelismos COVID-19 Unit, (Site 635-020), 1st Dept. of Pulmonary and Critical Care Medicine, Evangelismos General Hospital, Dept., Ipsilantou 45-47, Athens
"1st Respiratory Medicine Dept., Athens University Medical School (Site 635-015), Athens Hospital for Diseases of the Chest Sotiria Hospital, 152 Mesogeion Ave.", Athens
3rd Dept. of Medicine, Medical School, NKUA (Site 635-022), Sotiria General Hospital, 152 Mesogeion Ave., Athens
Attikon University General Hospital (Site 635-009), 4th Dept. of Internal Medicine, Medical School, National and Kapodistrian University of Athens, 1 Rimini St., Haidari, Athens
Wojewódzki Szpital Zakazny (Site 625-302), Wolska 37, Warsaw
Hospital Universitari Germans Trias i Pujol (Site 626-003), Infectious Disease Unit, Second Floor, Building Maternal, Road Canyet s/n, Badalona
Hospital Del Mar (Site 626-025), Paseo Maritimo 25-29, Barcelona
Hospital Universitari Vall d'Hebron (Site 626-033), Passeig de la Vall d'Hebron 119-129, Barcelona
Hospital Clínic de Barcelona (Site 626-004), Carrer de Villaroel 170, Barcelona
Hospital Universitario de Bellvitge (Site 626-034), Carrer de la Feixa Llarga, s/n, Barcelona
MRC/UVRI and LSHTM Uganda Research Unit (Site 634-601), Entebbe Regional Referral Hospital, Entebbe
Gulu Regional Referral Hospital (Site 634-603), Laroo Division, PO Box 160, Gulu
Makerere University Lung Institute (Site 634-604), New Mulago Hospital Complex, Mulago Hill, Kampala
St. Francis Hospital, Nsambya (Site 634-607), Nsambya Road Nsambya Hill, P.O. Box 7146, Kampala
Lira Regional Referral Hospital (Site 634-605), Lira
Masaka Regional Referral Hospital (Site 634-606), MRC/UVRI and LSHTM Uganda Research Unit, Plot 6 Circle Road, PO Box 556, Masaka
Royal Victoria Infirmary (Site 634-007), Queen Victoria Road, Newcastle upon Tyne
Royal Free Hospital (Site 634-006), Pond Street, Hampstead, London
Guy's and St. Thomas' NHS Foundation Trust (Site 634-011), London
Collaborators (3)
International Network for Strategic Initiatives in Global HIV Trials (INSIGHT)
NETWORK
University of Copenhagen
OTHER
Medical Research Council
OTHER_GOV
Kirby Institute
OTHER_GOV
Washington D.C. Veterans Affairs Medical Center
FED
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
NETWORK
National Heart, Lung, and Blood Institute (NHLBI)
NIH
US Department of Veterans Affairs
FED
Prevention and Early Treatment of Acute Lung Injury
OTHER
Cardiothoracic Surgical Trials Network
OTHER
AstraZeneca
INDUSTRY
University of Minnesota
OTHER
National Institute of Allergy and Infectious Diseases (NIAID)
NIH