NCT05773274 - Comparing Retreatment of 177Lu-DOTATATE PRRT Versus the Usual Treatment in Patients With Metastatic Unresectable Gastroenteropancreatic Neuroendocrine Tumors, NET RETREAT Trial | Biotech Hunter

Enrollment

100

Participants

Timeline

Start Date

January 12, 2024

Primary Completion Date

April 30, 2026

Study Completion Date

April 30, 2026

Conditions

Metastatic Digestive System Neuroendocrine Tumor G1Metastatic Digestive System Neuroendocrine Tumor G2Unresectable Digestive System Neuroendocrine Tumor G1Unresectable Digestive System Neuroendocrine Tumor G2

Interventions

PROCEDURE

Biospecimen Collection

Undergo collection of blood samples

DRUG

Cabozantinib

Given PO

PROCEDURE

Computed Tomography

Undergo CT scan

DRUG

Everolimus

Given PO

DRUG

Lutetium Lu 177 Dotatate

Given IV

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

OTHER

Quality-of-Life Assessment

Ancillary studies

OTHER

Questionnaire Administration

Ancillary studies

DRUG

Sunitinib

Given PO

Trial Locations (28)

14642

RECRUITING

University of Rochester, Rochester

33136

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

RECRUITING

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33180

RECRUITING

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

RECRUITING

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

35233

RECRUITING

University of Alabama at Birmingham Cancer Center, Birmingham

40536

RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

48202

RECRUITING

Henry Ford Hospital, Detroit

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

60115

RECRUITING

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60134

RECRUITING

Northwestern Medicine Cancer Center Delnor, Geneva

60451

RECRUITING

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

RECRUITING

University of Chicago Medicine-Orland Park, Orland Park

60555

RECRUITING

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

RECRUITING

Northwestern University, Chicago

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

80045

RECRUITING

UCHealth University of Colorado Hospital, Aurora

84112

RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

85054

RECRUITING

Mayo Clinic Hospital in Arizona, Phoenix

87106

RECRUITING

University of New Mexico Cancer Center, Albuquerque

32224-9980

ACTIVE_NOT_RECRUITING

Mayo Clinic in Florida, Jacksonville

V5Z 4E6

RECRUITING

BCCA-Vancouver Cancer Centre, Vancouver

R3E 0V9

RECRUITING

CancerCare Manitoba, Winnipeg

K1H 8L6

RECRUITING

Ottawa Hospital and Cancer Center-General Campus, Ottawa

M4N 3M5

RECRUITING

Odette Cancer Centre- Sunnybrook Health Sciences Centre, Toronto

All Listed Sponsors

lead

National Cancer Institute (NCI)

NIH