Organ Preservation in Rectal Cancer: Contact X-ray Brachytherapy vs Extending the Waiting Interval and Local Excision

NARecruitingINTERVENTIONAL
Enrollment

168

Participants

Timeline

Start Date

April 16, 2021

Primary Completion Date

March 31, 2025

Study Completion Date

March 31, 2029

Conditions
Organ PreservationRectal CancerQuality of LifeLocally Advanced Rectal Carcinoma
Interventions
RADIATION

Contact x-ray brachytherapy

With contact x-ray brachytherapy an intraluminal radiation boost up to 90 Gy is applied to the primary rectal tumour, with minimal collateral damage to the surrounding normal tissues due to minimal penetration of the 50 kVolt therapy.

PROCEDURE

Local excision

Local excision will basically be performed by the TAMIS-procedure (transanal minimally invasive surgery).

Trial Locations (7)

6500 HB

RECRUITING

Radbouw University Medical Centre, Nijmegen

5623EJ

RECRUITING

Catharina Hospital, Eindhoven

1066CX

RECRUITING

Antoni van Leeuwenhoek, Amsterdam

7416 SE

RECRUITING

Deventer Hospital, Deventer

8025 AB

RECRUITING

Isala, Zwolle

8934 AD

RECRUITING

Medical Center Leeuwarden, Leeuwarden

2906 ZC

RECRUITING

Ijsselland Hospital, Capelle aan den IJssel

All Listed Sponsors
collaborator

Catharina Ziekenhuis Eindhoven

OTHER

collaborator

ZonMw: The Netherlands Organisation for Health Research and Development

OTHER

lead

The Netherlands Cancer Institute

OTHER