Modulation of Ciliogenesis in Glioma Stem Cells

NACompletedINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

February 15, 2021

Primary Completion Date

December 31, 2023

Study Completion Date

July 13, 2024

Conditions
GlioblastomaGlioma, Malignant
Interventions
OTHER

Biological sample collection

Collection of tumor tissue and blood for stem cell culture and organoids generation.

OTHER

Dissecting ciliogenesis players

Assessment of cilium-related transcriptome in glioblastoma stem cells. Modulation of cilium-related genes and administration of cilium-targeted drugs to glioblastoma stem cells in vitro and ex vivo in glioblastoma brain organoids.

DIAGNOSTIC_TEST

Validating ciliogenesis players

Cilium-related signature will be studied in tumor tissue to evaluate its prognostic role.

Trial Locations (1)

00168

Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome

All Listed Sponsors
collaborator

Istituto Superiore di Sanità

OTHER

collaborator

"Fondazione C.N.R./Regione Toscana G. Monasterio, Pisa, Italy"

OTHER_GOV

lead

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

OTHER

NCT05772767 - Modulation of Ciliogenesis in Glioma Stem Cells | Biotech Hunter | Biotech Hunter