The THumb Osteoarthritis Exercise TriAl

NACompletedINTERVENTIONAL
Enrollment

166

Participants

Timeline

Start Date

September 1, 2020

Primary Completion Date

November 30, 2023

Study Completion Date

February 15, 2024

Conditions
Thumb Osteoarthritis
Interventions
OTHER

orthosis + exercise therapy

The orthosis + exercise group receives the same orthosis and instructions as the orthosis group (see next section), supplemented by exercise therapy. This includes weekly 25-30-minute physical therapy sessions with a total of 12 sessions. Sessions include patient education on thumb positioning, functional training and home exercise instructions to improve CMC-1 stability during pinch in extension/abduction, as instability and degeneration occurs in flexion/adduction(17,19,28-31). The first phase (week 0 - week 6) comprises coordination exercises for the thumb intrinsics (except adductor pollicis), extensor pollicis brevis and first dorsal interosseous to support CMC-1 extension/abduction. The second phase (week 6 - month 3) comprises reduced orthosis usage and thenar muscle strengthening exercises(except adductor pollicis).

OTHER

Orthosis

The orthosis group receives a custom-made thermoplastic orthosis immobilizing the first carpometacarpal joint (CMC-1) in extension/abduction and the metacarpophalangeal joint in flexion. Orthosis usage is 24/7 in the first two weeks, thereafter only during activities with high load until three months. Two appointments take place: one for orthosis fabrication and one for a one-week checkup.

Trial Locations (5)

5657 DD

Xpert Clinics (multiple sites), Eindhoven

5042AD

Elizabeth-TweeSteden Ziekenhuis, Tilburg

2906 ZC

IJsselland ziekenhuis, Capelle aan den IJssel

3045 PM

Franciscus Gasthuis, Rotterdam

2725 NA

Reinier Haga Orthopedisch Centrum, Zoetermeer

Sponsors
All Listed Sponsors
collaborator

ZonMw: The Netherlands Organisation for Health Research and Development

OTHER

collaborator

Xpert Clinics

UNKNOWN

collaborator

Franciscus Gasthuis

OTHER

collaborator

IJsselland ziekenhuis

UNKNOWN

collaborator

Reinier Haga Orthopedisch Centrum

OTHER

collaborator

Elisabeth-TweeSteden Ziekenhuis

OTHER

lead

Erasmus Medical Center

OTHER