SEARCH SAPPHIRE Phase B

NARecruitingINTERVENTIONAL
Enrollment

80,000

Participants

Timeline

Start Date

March 28, 2023

Primary Completion Date

March 31, 2026

Study Completion Date

March 31, 2026

Conditions
HIV
Interventions
BEHAVIORAL

Community-enhanced reach activities

We will conduct a series of community engagement activities designed to reach persons at risk for HIV, undiagnosed with HIV or diagnosed, or hypertension, and fallen out of care, working closely with community health workers, integrated in the community health system.

BEHAVIORAL

Person-centered care delivery

Structured approach to provide patient-centered biomedical options for HIV prevention (dynamic choice prevention). Tailored services for HIV treatment support using structured life stage evaluation and assessment plan (LEAP) for youth, pregnant women, and persons with or at risk of HIV viral non-suppression, that includes counselling for heavy alcohol users. Structured approach to offer telehealth for severe hypertension follow up.

OTHER

Data system enhancement to improve reach and person-centered delivery

Both community-enhanced reach and person-centered delivery will be strengthened through a customized in-country Ministry of Health-compatible community health worker smartphone app and two-way data system linking community health workers and clinical records.

BEHAVIORAL

Standard of Care

Standard of Care in Uganda and Kenya

Trial Locations (2)

Unknown

RECRUITING

SEARCH Office / GPRT, Kisumu

RECRUITING

Infectious Diseases Research Collaboration, Kampala

Sponsors
All Listed Sponsors
collaborator

Infectious Diseases Research Collaboration, Uganda

OTHER

collaborator

Makerere University

OTHER

collaborator

Kenya Medical Research Institute

OTHER

collaborator

University of California, Berkeley

OTHER

collaborator

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

collaborator

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NIH

collaborator

National Institute of Mental Health (NIMH)

NIH

collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

University College, London

OTHER

lead

University of California, San Francisco

OTHER

NCT05768763 - SEARCH SAPPHIRE Phase B | Biotech Hunter | Biotech Hunter