First-in-Human Study of STX-478 as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

720

Participants

Timeline

Start Date

April 17, 2023

Primary Completion Date

July 31, 2030

Study Completion Date

July 31, 2030

Conditions
Breast CancerSolid Tumors, Adult
Interventions
DRUG

STX-478

STX-478 is a mutant-selective PI3Kα inhibitor

DRUG

Fulvestrant

Fulvestrant

DRUG

Ribociclib

Ribociclib

DRUG

Palbociclib

Palbociclib

DRUG

Letrozole

Letrozole

DRUG

Anastrozole

Anastrozole

DRUG

Exemestane

Exemestane

Trial Locations (55)

168

RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli, Roma

1070

NOT_YET_RECRUITING

Institut Jules Bordet, Anderlecht

3000

NOT_YET_RECRUITING

UZ Leuven, Leuven

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

20133

RECRUITING

Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan

20141

RECRUITING

Istituto Europeo di Oncologia, Milan

20900

RECRUITING

Fondazione IRCCS San Gerardo dei Tintori, Monza

22031

RECRUITING

USO-Virginia Cancer Specialists, PC, Fairfax

26006

NOT_YET_RECRUITING

Hospital San Pedro, Logroño

28040

RECRUITING

Hospital Clinico San Carlos, Madrid

RECRUITING

Hospital Universitario Fundación Jiménez Díaz, Madrid

28050

RECRUITING

Hospital Universitario HM Sanchinarro, Madrid

28223

RECRUITING

Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcón

30322

NOT_YET_RECRUITING

Winship Cancer Institute, Emory University, Atlanta

31059

RECRUITING

Institut Claudius Regaud, Toulouse

32746

RECRUITING

Florida Cancer Specialists ORLANDO/DDU, Lake Mary

33000

RECRUITING

Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest, Bordeaux

33612

RECRUITING

Moffitt Cancer Center, Tampa

37203

RECRUITING

Sarah Cannon Research Institute, Nashville

38138

RECRUITING

The West Clinic, PLLC dba West Cancer Center, Germantown

43212

RECRUITING

Stefanie Spielman Comprehensive Breast Center, Columbus

44106

RECRUITING

UH Cleveland Medical Center, Cleveland

48201

RECRUITING

Barbara Ann Karmanos Cancer Institute, Detroit

49546

RECRUITING

START Midwest, Grand Rapids

52242

RECRUITING

University of Iowa, Iowa City

63110

NOT_YET_RECRUITING

Washington University, St Louis

69008

RECRUITING

Centre Leon Berard, Lyon

70112

RECRUITING

Louisiana State University Health Sciences Center, New Orleans

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

75230

COMPLETED

Mary Crowley Cancer Research Center, Dallas

75390

NOT_YET_RECRUITING

University of Texas Southwestern, Dallas

77030

RECRUITING

University of Texas MD Anderson Cancer Center, Houston

78229

RECRUITING

START San Antonio, San Antonio

80045

RECRUITING

University of Colorado Cancer Center, Aurora

84119

RECRUITING

START Mountain Region, West Valley City

91054

NOT_YET_RECRUITING

Universitätsklinikum Erlangen, Erlangen

94143

RECRUITING

UCSF Medical Center at Mission Bay, San Francisco

94805

RECRUITING

Gustave Roussy, Villejuif

97213

RECRUITING

Providence Cancer Institute Franz Clinic, Portland

90025-6602

RECRUITING

The Angeles Clinic & Research Institute, Los Angeles

06510

COMPLETED

Yale-New Haven Hospital, New Haven

02115

RECRUITING

Massachusetts General Hospital, Boston

02215

RECRUITING

Dana-Farber Cancer Institute, Boston

64111-3220

RECRUITING

Saint Luke's Cancer Institute, Kansas City

75246-2092

RECRUITING

Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas

05401

NOT_YET_RECRUITING

University of Vermont Medical Center, Burlington

Unknown

RECRUITING

Mater Misericordiae Hospital, Dublin

811-1395

NOT_YET_RECRUITING

National Hospital Organization Kyushu Cancer Center, Fukuoka

573-1191

NOT_YET_RECRUITING

Kansai Medical University Hospital, Hirakata

135-8550

NOT_YET_RECRUITING

The Cancer Institute Hospital of JFCR, Kōtō City

606-8507

NOT_YET_RECRUITING

Kyoto University Hospital, Kyoto

1066CX

RECRUITING

Netherlands Cancer Institute, Amsterdam

3015GD

RECRUITING

Erasmus MC, Rotterdam

08023

RECRUITING

South Texas Accelerated Research Therapeutics (START) Barcelona- HM Nou Delfos, Barcelona

08035

RECRUITING

Hospital Universitari Vall d'Hebron, Barcelona

All Listed Sponsors
lead

Eli Lilly and Company

INDUSTRY