Bone, Exercise, Alendronate, and Caloric Restriction

PHASE4RecruitingINTERVENTIONAL
Enrollment

900

Participants

Timeline

Start Date

June 8, 2023

Primary Completion Date

September 30, 2027

Study Completion Date

September 30, 2027

Conditions
Bone Loss
Interventions
DRUG

Bisphosphonate

Medicine used to treat bone problems, called osteopenia or osteoporosis.

BEHAVIORAL

Resistance Training/Bone-Loading Exercise

Exercise in small groups three days per week under the supervision of exercise physiologists. Heart rate and blood pressure will be measured before and after each session and participants will warm-up by walking or cycling for five minutes at a slow pace. All RT exercises will be conducted on machines which accommodate different body sizes and allow small increments in resistance, both important considerations for low functioning older adults with obesity.

OTHER

Placebo

Capsules identical to the active alendronate capsules without any active ingredients with the same dosing and follow up as BIS treatment group.

Trial Locations (2)

27157

RECRUITING

Atrium Health Wake Forest Baptist, Winston-Salem

80045

RECRUITING

University of Colorado Anschutz Medical Campus, Aurora

All Listed Sponsors
collaborator

National Institute on Aging (NIA)

NIH

lead

Wake Forest University Health Sciences

OTHER