NCT05764044View on ClinicalTrials.gov

Adjuvant Chemotherapy in cfHPV-DNA Plasma Positive Patients: A Biomarker In Locally Advanced Cervical Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

365

Participants

Timeline

Start Date

March 27, 2024

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2026

Conditions
Cervical CancerCervix CancerCervix Neoplasm
Interventions
DRUG

cisplatin, gemcitabine

Two additional cycles of cisplatin-based adjuvant chemotherapy 50mg/m2 D1 and gemcitabine 1000mg/m2 D1 and D8 at every 21 days.

OTHER

Follow-up

Patients will be followed with plasma cfDNA-HPV, computed tomography (CT) scan of the thorax and magnetic resonance (MRI) of abdomen and pelvis and clinical and gynecological examination at every four months.

Trial Locations (26)

69.020-030

RECRUITING

Centro Integrado de Pesquisa da Amazônia, CINPAM, Manaus

29.308-065

NOT_YET_RECRUITING

Hospital Evangélico de Cachoeiro de Itapemirim, Cachoeiro de Itapemirim

45.023-145

NOT_YET_RECRUITING

Hospital Samur, Vitória da Conquista

70.335-900

NOT_YET_RECRUITING

Hospital de Base do Distrito Federal, Brasília

36.888-233

RECRUITING

Hospital do Câncer de Muriaé, Muriaé

85.803-760

NOT_YET_RECRUITING

Centro de Oncologia de Cascavel, CEONC, Cascavel

85.810-031

NOT_YET_RECRUITING

União Oeste Paranaense de Estudos e Combate ao Câncer, UOPECCAN, Cascavel

80810-050

NOT_YET_RECRUITING

Centro Integrado de Oncologia de Curitiba, CIONC, Curitiba

20.220-410

RECRUITING

Instituto Nacional do Câncer, INCA, Rio de Janeiro

59.062-000

NOT_YET_RECRUITING

Liga Norte Riograndense Contra o Câncer, Natal

95.700-084

NOT_YET_RECRUITING

Hospital Tacchini, Bento Gonçalves

95.070-561

NOT_YET_RECRUITING

Hospital Geral de Caxias do Sul, Caxias do Sul

95.900-010

NOT_YET_RECRUITING

Hospital Bruno Born, Lajeado

90.850- 170

NOT_YET_RECRUITING

Centro Gaúcho Integrado Hospital Mãe de Deus, Porto Alegre

69.304-015

NOT_YET_RECRUITING

Centro Oncologico de Roraima, CECOR, Boa Vista

88.301-220

NOT_YET_RECRUITING

Catarina Pesquisa Clínica, Itajaí

89.204-061

RECRUITING

Hospital Unimed, Joinville

13.083-881

NOT_YET_RECRUITING

Centro de Atenção Integral a Saúde da Mulher, CAISM, Campinas

15.706-396

NOT_YET_RECRUITING

Hospital do Amor, Jales

01.206-001

RECRUITING

Hospital da Mulher - SECONCI, São Paulo

04.005-000

RECRUITING

Hospital do Coração - Research Institute, São Paulo

04.015-070

NOT_YET_RECRUITING

Instituto Brasileiro de Combate ao Câncer, IBCC São Camilo, São Paulo

04.024-002

NOT_YET_RECRUITING

Hospital São Paulo, Unifesp, São Paulo

08.270-120

RECRUITING

Hospital Santa Marcelina, São Paulo

09.060-650

NOT_YET_RECRUITING

Centro de Estudos e Pesquisa de Hematologia, CEPHO, São Paulo

12.030-200

NOT_YET_RECRUITING

Instituo de Câncer Brasil, ICB, Taubaté

All Listed Sponsors
collaborator

University of Sao Paulo

OTHER

lead

Hospital do Coracao

OTHER