78
Participants
Start Date
January 8, 2024
Primary Completion Date
December 31, 2027
Study Completion Date
December 31, 2027
Biospecimen Collection
Undergo collection of blood and CSF samples
Bone Marrow Aspiration
Undergo bone marrow aspiration
Calaspargase Pegol
Given IV
Cytarabine
Given IV and IT
Echocardiography Test
Undergo ECHO
Fludarabine Phosphate
Given IV
Hydrocortisone Sodium Succinate
Given IT
Lumbar Puncture
Undergo lumbar puncture
Methotrexate
Given IT
Multigated Acquisition Scan
Undergo MUGA scan
Prednisolone
Given PO or via NG, NJ, ND or G-tube
Prednisone
Given PO or via NG, NJ, ND or G-tube
Revumenib
Given PO or via NG, NJ, ND or G-tube
Vincristine Sulfate
Given IV
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
Memorial Sloan Kettering Cancer Center, New York
Albany Medical Center, Albany
State University of New York Upstate Medical University, Syracuse
Roswell Park Cancer Institute, Buffalo
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
Geisinger Medical Center, Danville
Children's Hospital of Philadelphia, Philadelphia
Saint Christopher's Hospital for Children, Philadelphia
Alfred I duPont Hospital for Children, Wilmington
Children's National Medical Center, Washington D.C.
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
University of Virginia Cancer Center, Charlottesville
Children's Hospital of The King's Daughters, Norfolk
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
Prisma Health Richland Hospital, Columbia
BI-LO Charities Children's Cancer Center, Greenville
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta
University of Florida Health Science Center - Gainesville, Gainesville
AdventHealth Orlando, Orlando
Arnold Palmer Hospital for Children, Orlando
Nemours Children's Hospital, Orlando
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
Nicklaus Children's Hospital, Miami
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
Golisano Children's Hospital of Southwest Florida, Fort Myers
Children's Hospital of Alabama, Birmingham
The Children's Hospital at TriStar Centennial, Nashville
Vanderbilt University/Ingram Cancer Center, Nashville
Saint Jude Children's Research Hospital, Memphis
University of Mississippi Medical Center, Jackson
University of Kentucky/Markey Cancer Center, Lexington
Nationwide Children's Hospital, Columbus
Children's Hospital Medical Center of Akron, Akron
Cincinnati Children's Hospital Medical Center, Cincinnati
Dayton Children's Hospital, Dayton
Riley Hospital for Children, Indianapolis
C S Mott Children's Hospital, Ann Arbor
Children's Hospital of Michigan, Detroit
Bronson Methodist Hospital, Kalamazoo
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
University of Minnesota/Masonic Cancer Center, Minneapolis
Sanford Broadway Medical Center, Fargo
Lurie Children's Hospital-Chicago, Chicago
University of Chicago Comprehensive Cancer Center, Chicago
Washington University School of Medicine, St Louis
Mercy Hospital Saint Louis, St Louis
Children's Mercy Hospitals and Clinics, Kansas City
Children's Hospital and Medical Center of Omaha, Omaha
University of Nebraska Medical Center, Omaha
Medical City Dallas Hospital, Dallas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
Cook Children's Medical Center, Fort Worth
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
M D Anderson Cancer Center, Houston
Children's Hospital of San Antonio, San Antonio
Dell Children's Medical Center of Central Texas, Austin
Children's Hospital Colorado, Aurora
University of New Mexico Cancer Center, Albuquerque
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas
Renown Regional Medical Center, Reno
Kaiser Permanente Downey Medical Center, Downey
Loma Linda University Medical Center, Loma Linda
UCSF Medical Center-Mission Bay, San Francisco
UCSF Benioff Children's Hospital Oakland, Oakland
Kaiser Permanente-Oakland, Oakland
Legacy Emanuel Children's Hospital, Portland
Oregon Health and Science University, Portland
Seattle Children's Hospital, Seattle
Arkansas Children's Hospital, Little Rock
Connecticut Children's Medical Center, Hartford
Hackensack University Medical Center, Hackensack
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick
Newark Beth Israel Medical Center, Newark
Sanford USD Medical Center - Sioux Falls, Sioux Falls
British Columbia Children's Hospital, Vancouver
CancerCare Manitoba, Winnipeg
IWK Health Centre, Halifax
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton
Children's Hospital, London
Children's Hospital of Eastern Ontario, Ottawa
Hospital for Sick Children, Toronto
Centre Hospitalier Universitaire Sainte-Justine, Montreal
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Québec
Children's Oncology Group
NETWORK