60
Participants
Start Date
March 4, 2021
Primary Completion Date
September 30, 2025
Study Completion Date
December 30, 2025
quantification of sensory and autonomic small nerve fibers by punch skin biopsy
We'll perform a punch skin biopsy of 3mm from thigh, leg and fingertip and we'll quantify peripheral sensory and autonomic nerve fibers.
Cardiovascular Reflexes testing
Cardiovascular reflex tests including deep breathing, head-up Tilt, standing, isometric exercises, mental arithmetic and Valsalva maneuver.
Administration of clinical scales evaluating autonomic symptoms, pain small fiber neuropathy symptoms
We'll characterize patients' symptoms through the administration of clinical scales such as: COMPASS 31 autonomic symptoms scale; Small Fiber Neuropathy Symptom Inventory Questionnaire (SFN-SIQ), the Pain Detect Questionnaire and the Total neuropathy score
RECRUITING
Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Napoli
RECRUITING
ICS Maugeri - IRCCS of Telese Terme, Telese Terme
Istituti Clinici Scientifici Maugeri SpA
OTHER