At High-risk for Pre-eclampsia After Assisted Reproductive Technology

"The procedure is performed without any anesthesia and takes approximately 5 minutes.~A small plastic pipelle is put through the cervix into the uterine cavity. The endometrial tissue is aspirated into the pipelle."

Evaluation of fetal biometry and doppler flow study using ultrasound.

single puncture collection of peripheral venous blood.

Collection of urine in a plastic cup.

Start with daily estradiol (progynova, oestrogel) administration at hormonal baseline (day 2 of the cycle or with confirmation using endocrine evaluation). When adequate thickness (≥6.5 mm) of the endometrium is achieved (usually after 10-14 days), progesterone is administered daily. 6 days after progesterone administration, the pipelle biopsy will be performed. When this test cycle has ended and menstruation starts, patients will be asked to collect their menstrual flow, during the first night of heavy/red flow, in a menstrual cup. The next day patients will be asked to bring their collected menstrual blood to our center and they will undergo a blood analysis needed for the start of their ART treatment.

questionnaire the patient has to fill in

collection of menstrual blood during the first day of heavy menstrual flow for at least 6 hours

Including body composition analysis by BIA/whole body MRI and analysis of resting energy expenditure (REE).

Using transthoracic ultrasound.

Blood pressure measurement