Study of RP3 in Combination With Nivolumab and Other Therapy in Patients With Locoregionally Advanced or Recurrent SCCHN

PHASE2WithdrawnINTERVENTIONAL
0
Timeline

Start Date

January 30, 2024

Primary Completion Date

March 1, 2026

Study Completion Date

June 1, 2026

Conditions
Squamous Cell Carcinoma of Head and NeckLocally Advanced Head and Neck Squamous Cell CarcinomaRecurrent Head and Neck Squamous Cell Carcinoma
Interventions
BIOLOGICAL

RP3

Genetically modified herpes simplex type 1 virus

OTHER

CCRT(concurrent chemoradiation therapy)

CCRT consisting of intensity modulated radiation therapy combined with a cis-platinum

OTHER

carboplatin and paclitaxel

chemotherapeutic agents

BIOLOGICAL

nivolumab

anti-PD1 monoclonal antibody

Trial Locations (34)

12203

Charite University Hospital of Berlin, Comprehensive Cancer Center, Berlin

12462

University General Hospital Attikon, Chaïdári

13005

Assistance Publique Hopitaux De Marseille, Marseille

15232

University of Pittsburgh Medical Center, UPMC, Pittsburgh

19090

Jefferson Health Abington Asplunhd Cancer Pavillion, Willow Grove

19107

Thomas Jefferson University City Center and Abington, Philadelphia

21079

Centre Georges Francois Leclerc, Department of Oncology, Dijon

28046

La Paz Univeristy Hospital, Universidad Autonoma de Madrid, Madrid

28050

Hospital Universitario HM Sanchinarro, Madrid

30029

CHU Nimes, Instiut de Cancerologie du Gard, Medical Oncology, Nîmes

31008

Clinica Universitaria de Navarra, Pamplona

37203

Sarah Cannon Research Institute, Nashville

44195

Cleveland Clinic, Cleveland

45219

University of Cincinnati Medical Center, Cincinnati

46009

Fundacion Instituto Valenciano de Oncologia, Valencia

52242

University of Iowa Hospitals and Clinics, Iowa City

53226

Medical College of Wisconsin, Milwaukee

55236

Agios Lukas Hospital, Thessaloniki

69008

Centre Leon Berard, Lyon

81377

LMU Klinikum, Medizinische Klinik und Poliklinikum III, Munich

89075

Universitatsklinikum Ulm, Ulm

90033

USC Norris Comprehensive Cancer Center, Los Angeles

90095

UCLA Medicine Division of Hematology-Oncology, Los Angeles

92037

University of California San Diego, UCSD, La Jolla

94805

Institut Gustave Roussy Paris, Villejuif

98109

University of Washington / Fred Hutchinson Cancer Center, Seattle

779 00

University Hospital Olomouc, Olomouc

100 00

FN Kralovske Vinohrady, Prague

140 59

Fakultni Thomayerova Nemocnice, Prague

07747

Universitatsklinik Jena Klinik und Poliklinik fur Hals-, Nasen - und Ohrenheilkunde, Jena

04103

University Hospital Leipzig Clinic and Polyclinic for otorhinolaryngology, Leipzig

31-826

Szpital Specjalistyczny im Ludwika Rydygiera w Krakowie sp z oo, Department of Clinical Oncology, Krakow

08035

Vall d'Hebron University Hospital, Vall d' Hebron Institute of Oncology (VHIO), Barcelona

SW3 6JJ

The Royal Marsden NHS Foundation Trust, London

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Replimune Inc.

INDUSTRY