Long-term Efficacy and Safety of Tozorakimab in Participants With Chronic Obstructive Pulmonary Disease With a History of Exacerbations (PROSPERO).

PHASE3RecruitingINTERVENTIONAL
Enrollment

1,869

Participants

Timeline

Start Date

March 6, 2023

Primary Completion Date

June 16, 2026

Study Completion Date

August 17, 2026

Conditions
Chronic Obstructive Pulmonary Disease (COPD)
Interventions
COMBINATION_PRODUCT

Tozorakimab 1

Participants randomised to either dose regimen in the predecessor studies will be assigned to a single Tozorakimab dose regimen in the PROSPERO study.

COMBINATION_PRODUCT

Tozorakimab 2

Participants randomised to either dose regimen in the predecessor studies will be assigned to a single Tozorakimab dose regimen in the PROSPERO study.

COMBINATION_PRODUCT

Placebo

Participants previously randomised to placebo in one of the predecessor studies will be re-randomised in a 1:1 ratio to the active dose of Tozorakimab or placebo.

Trial Locations (389)

110

RECRUITING

Research Site, Taipei

300

RECRUITING

Research Site, Hsinchu

333

RECRUITING

Research Site, Taoyuan District

450

COMPLETED

Research Site, Oslo

640

COMPLETED

Research Site, Yunlin

1000

ACTIVE_NOT_RECRUITING

Research Site, Brussels

ACTIVE_NOT_RECRUITING

Research Site, Sofia

WITHDRAWN

Research Site, Manila

1036

COMPLETED

Research Site, Budapest

1478

RECRUITING

Research Site, Lørenskog

1606

COMPLETED

Research Site, Sofia

1888

ACTIVE_NOT_RECRUITING

Research Site, San Juan Bautista

2109

COMPLETED

Research Site, Macquarie University

2400

ACTIVE_NOT_RECRUITING

Research Site, Copenhagen

2440

ACTIVE_NOT_RECRUITING

Research Site, Százhalombatta

2500

RECRUITING

Research Site, Wollongong

2560

ACTIVE_NOT_RECRUITING

Research Site, Campbelltown

2600

ACTIVE_NOT_RECRUITING

Research Site, Dupnitsa

RECRUITING

Research Site, Baguio City

2650

RECRUITING

Research Site, Hvidovre

2850

COMPLETED

Research Site, Petrich

3000

RECRUITING

Research Site, Melbourne

RECRUITING

Research Site, Leuven

ACTIVE_NOT_RECRUITING

Research Site, Vratsa

3103

ACTIVE_NOT_RECRUITING

Research Site, Tønsberg

3199

COMPLETED

Research Site, Frankstown

3200

WITHDRAWN

Research Site, Gyöngyös

3320

ACTIVE_NOT_RECRUITING

Research Site, Kozloduy

3780

RECRUITING

Research Site, Edelény

3860

COMPLETED

Research Site, Encs

4000

RECRUITING

Research Site, Liège

RECRUITING

Research Site, Roskilde

4032

RECRUITING

Research Site, Debrecen

4215

RECRUITING

Research Site, Southport

4481

RECRUITING

Research Site, Nyíregyháza-Sóstóhegy

4700

RECRUITING

Research Site, Næstved

5000

ACTIVE_NOT_RECRUITING

Research Site, Iloilo City

RECRUITING

Research Site, Iloilo City

5011

RECRUITING

Research Site, Woodville South

5021

WITHDRAWN

Research Site, Bergen

5101

RECRUITING

Research Site, Namur

5500

ACTIVE_NOT_RECRUITING

Research Site, Lovech

5501

WITHDRAWN

Research Site, Godoy Cruz

5600

WITHDRAWN

Research Site, Troyan Municipality

5800

ACTIVE_NOT_RECRUITING

Research Site, Pleven

6000

RECRUITING

Research Site, Cebu City

6009

RECRUITING

Research Site, Nedlands

6163

COMPLETED

Research Site, Spearwood

7002

ACTIVE_NOT_RECRUITING

Research Site, Rousse

7100

ACTIVE_NOT_RECRUITING

Research Site, Vejle

7600

ACTIVE_NOT_RECRUITING

Research Site, Mar del Plata

8092

WITHDRAWN

Research Site, Bodø

8800

ACTIVE_NOT_RECRUITING

Research Site, Sliven

9000

RECRUITING

Research Site, Ghent

RECRUITING

Research Site, Aalborg

9200

ACTIVE_NOT_RECRUITING

Research Site, Mosonmagyaróvár

10000

COMPLETED

Research Site, Hanoi

10002

RECRUITING

Research Site, Taipei

10037

NOT_YET_RECRUITING

Research Site, New York

10700

WITHDRAWN

Research Site, Bangkok

10717

COMPLETED

Research Site, Berlin

11000

RECRUITING

Research Site, Bang Kra So

11239

RECRUITING

Research Site, Stockholm

11527

WITHDRAWN

Research Site, Athens

COMPLETED

Research Site, Athens

12157

COMPLETED

Research Site, Berlin

13100

ACTIVE_NOT_RECRUITING

Research Site, Vercelli

13326

ACTIVE_NOT_RECRUITING

Research Site, Marseille

13530

COMPLETED

Research Site, Hämeenlinna

14010

COMPLETED

Research Site, Baotou

14203

RECRUITING

Research Site, Buffalo

15036

RECRUITING

Research Site, Lima

15046

RECRUITING

Research Site, Lima

15088

RECRUITING

Research Site, Lima

15213

RECRUITING

Research Site, Pittsburgh

15801

RECRUITING

Research Site, DuBois

18840

RECRUITING

Research Site, Sayre

19140

RECRUITING

Research Site, Philadelphia

20000

ACTIVE_NOT_RECRUITING

Research Site, Mueang

20001

WITHDRAWN

Research Site, Piura

20142

RECRUITING

Research Site, Milan

20157

COMPLETED

Research Site, Milan

20520

RECRUITING

Research Site, Turku

21049

ACTIVE_NOT_RECRUITING

Research Site, Tradate

21079

RECRUITING

Research Site, Dijon

21162

RECRUITING

Research Site, White Marsh

21224

RECRUITING

Research Site, Baltimore

21431

RECRUITING

Research Site, Incheon

22000

ACTIVE_NOT_RECRUITING

Research Site, Muang

22926

COMPLETED

Research Site, Ahrensburg

23188

RECRUITING

Research Site, Williamsburg

26500

COMPLETED

Research Site, Pátrai

27705

RECRUITING

Research Site, Durham

28040

RECRUITING

Research Site, Madrid

28054

ACTIVE_NOT_RECRUITING

Research Site, Gastonia

28223

RECRUITING

Research Site, Pozuelo de Alarcón

29010

RECRUITING

Research Site, Málaga

29609

ACTIVE_NOT_RECRUITING

Research Site, Brest

29732

ACTIVE_NOT_RECRUITING

Research Site, Rock Hill

30000

ACTIVE_NOT_RECRUITING

Research Site, Nakhon Ratchasima

31000

RECRUITING

Research Site, Chihuahua City

31224

COMPLETED

Research Site, Peine

31300

RECRUITING

Research Site, Toulouse

32174

ACTIVE_NOT_RECRUITING

Research Site, Ormond Beach

32503

COMPLETED

Research Site, Pensacola

32789

ACTIVE_NOT_RECRUITING

Research Site, Winter Park

33076

RECRUITING

Research Site, Bordeaux

33324

RECRUITING

Research Site, Plantation

33343

RECRUITING

Research Site, Mersin

33435

COMPLETED

Research Site, Boynton Beach

33520

WITHDRAWN

Research Site, Tampere

33607

WITHDRAWN

Research Site, Tampa

COMPLETED

Research Site, Tampa

33990

RECRUITING

Research Site, Cape Coral

34295

ACTIVE_NOT_RECRUITING

Research Site, Montpellier

34854

RECRUITING

Research Site, Istanbul

35037

COMPLETED

Research Site, Marburg

35660

COMPLETED

Research Site, Sheffield

35801

WITHDRAWN

Research Site, Huntsville

37067

RECRUITING

Research Site, Franklin

37124

RECRUITING

Research Site, Verona

38700

RECRUITING

Research Site, La Tronche

39008

RECRUITING

Research Site, Santander

40002

COMPLETED

Research Site, Khon Kaen

40447

RECRUITING

Research Site, Taichung

40705

RECRUITING

Research Site, Taichung

41345

RECRUITING

Research Site, Gothenburg

42101

ACTIVE_NOT_RECRUITING

Research Site, Bowling Green

42415

RECRUITING

Research Site, Daegu

43617

RECRUITING

Research Site, Toledo

44093

RECRUITING

Research Site, Nantes

44100

RECRUITING

Research Site, Guadalajara

44200

RECRUITING

Research Site, Guadalajara

45500

ACTIVE_NOT_RECRUITING

Research Site, Ioannina

46010

RECRUITING

Research Site, Valencia

46143

RECRUITING

Research Site, Greenwood

48336

RECRUITING

Research Site, Farmington Hills

48960

RECRUITING

Research Site, Galdakao

49546

RECRUITING

Research Site, Grand Rapids

50009

RECRUITING

Research Site, Zaragoza

50051

ACTIVE_NOT_RECRUITING

Research Site, Shijiazhuang

50159

WITHDRAWN

Research Site, Bucharest

51069

COMPLETED

Research Site, Cologne

52242

WITHDRAWN

Research Site, Iowa City

53110

RECRUITING

Research Site, Cudahy

54033

ACTIVE_NOT_RECRUITING

Research Site, Carrara

54907

ACTIVE_NOT_RECRUITING

Research Site, Jeonju

55000

COMPLETED

Research Site, Muang,

55001

WITHDRAWN

Research Site, Broumov

55905

RECRUITING

Research Site, Rochester

57010

ACTIVE_NOT_RECRUITING

Research Site, Exohi Thessaloniki

ACTIVE_NOT_RECRUITING

Research Site, Thessaloniki

58000

RECRUITING

Research Site, Morelia

58104

RECRUITING

Research Site, Fargo

59808

WITHDRAWN

Research Site, Missoula

60805

RECRUITING

Research Site, Evergreen Park

61761

RECRUITING

Research Site, Normal

63110

RECRUITING

Research Site, St Louis

64283

COMPLETED

Research Site, Darmstadt

64460

RECRUITING

Research Site, Monterrey

66160

RECRUITING

Research Site, Kansas City

68020

RECRUITING

Research Site, Oaxaca City

68100

COMPLETED

Research Site, Alexandroupoli

69317

ACTIVE_NOT_RECRUITING

Research Site, Lyon

70124

RECRUITING

Research Site, Bari

70210

RECRUITING

Research Site, Kuopio

70791

COMPLETED

Research Site, Zachary

70836

ACTIVE_NOT_RECRUITING

Research Site, Baton Rouge

74010

RECRUITING

Research Site, Statte

74133

WITHDRAWN

Research Site, Tulsa

RECRUITING

Research Site, Tulsa

75069

RECRUITING

Research Site, McKinney

76100

ACTIVE_NOT_RECRUITING

Research Site, Rehovot

76104

WITHDRAWN

Research Site, Fort Worth

77022

WITHDRAWN

Research Site, Houston

77339

RECRUITING

Research Site, Kingwood

77375

RECRUITING

Research Site, Tomball

77598

WITHDRAWN

Research Site, Webster

78006

NOT_YET_RECRUITING

Research Site, Boerne

78278

RECRUITING

Research Site, Ashkelon

79106

WITHDRAWN

Research Site, Amarillo

RECRUITING

Research Site, Amarillo

80007

RECRUITING

Research Site, Barranquilla

80131

RECRUITING

Research Site, Napoli

WITHDRAWN

Research Site, Napoli

80336

WITHDRAWN

Research Site, München

80756

RECRUITING

Research Site, Kaohsiung City

81241

WITHDRAWN

Research Site, München-Pasing

82037

RECRUITING

Research Site, Telese Terme

84131

RECRUITING

Research Site, Salerno

85283

RECRUITING

Research Site, Tempe

87000

WITHDRAWN

Research Site, Limoges

90110

RECRUITING

Research Site, Hat Yai

COMPLETED

Research Site, Hat Yai

91324

COMPLETED

Research Site, Northridge

91910

RECRUITING

Research Site, Veracruz

92663

COMPLETED

Research Site, Newport Beach

93301

WITHDRAWN

Research Site, Bakersfield

95648

RECRUITING

Research Site, Lincoln

96049

COMPLETED

Research Site, Bamberg

97070

WITHDRAWN

Research Site, Mérida

100000

RECRUITING

Research Site, Hanoi

100057

ACTIVE_NOT_RECRUITING

Research Site, Beijing

100144

COMPLETED

Research Site, Beijing

110000

COMPLETED

Research Site, Shenyang

110004

COMPLETED

Research Site, Shenyang

110029

RECRUITING

Research Site, New Delhi

130021

COMPLETED

Research Site, Changchun

200002

COMPLETED

Research Site, Shanghai

200251

ACTIVE_NOT_RECRUITING

Research Site, Zipaquirá

201199

COMPLETED

Research Site, Shanghai

210006

ACTIVE_NOT_RECRUITING

Research Site, Nanjing

214023

COMPLETED

Research Site, Wuxi

215002

COMPLETED

Research Site, Suzhou

221000

COMPLETED

Research Site, Xuzhou

221009

ACTIVE_NOT_RECRUITING

Research Site, Xuzhou

225001

ACTIVE_NOT_RECRUITING

Research Site, Yangzhou

230001

WITHDRAWN

Research Site, Hefei

248001

RECRUITING

Research Site, Dehradun

300002

ACTIVE_NOT_RECRUITING

Research Site, Timișoara

300050

WITHDRAWN

Research Site, Tianjin

302039

RECRUITING

Research Site, Jaipur

310006

COMPLETED

Research Site, Hangzhou

315010

COMPLETED

Research Site, Ningbo

317000

COMPLETED

Research Site, Linhai

330006

COMPLETED

Research Site, Nanchang

WITHDRAWN

Research Site, Nanchang

361004

COMPLETED

Research Site, Xiamen

400013

COMPLETED

Research Site, Chongqing

400037

COMPLETED

Research Site, Chongqing

400371

COMPLETED

Research Site, Cluj-Napoca

401107

RECRUITING

Research Site, Thāne

410015

COMPLETED

Research Site, Changsha

415003

WITHDRAWN

Research Site, Changde

422007

RECRUITING

Research Site, Nashik

430022

COMPLETED

Research Site, Wuhan

440012

RECRUITING

Research Site, Nagpur

500283

ACTIVE_NOT_RECRUITING

Research Site, Brasov

510180

COMPLETED

Research Site, Guangzhou

510630

WITHDRAWN

Research Site, Guangzhou

510735

ACTIVE_NOT_RECRUITING

Research Site, Guangzhou

518020

ACTIVE_NOT_RECRUITING

Research Site, Shenzhen

518053

COMPLETED

Research Site, Shenzhen

524004

COMPLETED

Research Site, Zhanjiang

563100

COMPLETED

Research Site, Zunyi

570311

ACTIVE_NOT_RECRUITING

Research Site, Haikou

590010

RECRUITING

Research Site, Belagavi

610000

ACTIVE_NOT_RECRUITING

Research Site, Chengdu

610014

COMPLETED

Research Site, Chengdu

610083

WITHDRAWN

Research Site, Chengdu

641028

RECRUITING

Research Site, Coimbatore

650032

COMPLETED

Research Site, Kunming

700000

RECRUITING

Research Site, Ho Chi Minh City

730006

RECRUITING

Research Site, Ibagué

750004

COMPLETED

Research Site, Yinchuan

900002

WITHDRAWN

Research Site, Constanța

3341643

ACTIVE_NOT_RECRUITING

Research Site, Curicó

3465584

ACTIVE_NOT_RECRUITING

Research Site, Talca

4428164

RECRUITING

Research Site, Kfar Saba

6423906

RECRUITING

Research Site, Tel Aviv

7500010

ACTIVE_NOT_RECRUITING

Research Site, Santiago

7500698

ACTIVE_NOT_RECRUITING

Research Site, Santiago

7770484

ACTIVE_NOT_RECRUITING

Research Site, Chile

8150000

ACTIVE_NOT_RECRUITING

Research Site, Santiago

8241479

WITHDRAWN

Research Site, Santiago

8410101

COMPLETED

Research Site, Beersheba

9103102

ACTIVE_NOT_RECRUITING

Research Site, Jerusalem

90035074

ACTIVE_NOT_RECRUITING

Research Site, Porto Alegre

02747

COMPLETED

Research Site, North Dartmouth

05446

RECRUITING

Research Site, Colchester

C1121 ABE

ACTIVE_NOT_RECRUITING

Research Site, Buenos Aires

C1414AIF

RECRUITING

Research Site, Buenos Aires

C1425BEN

RECRUITING

Research Site, CABA

X5003DCE

RECRUITING

Research Site, Córdoba

B7600GWV

ACTIVE_NOT_RECRUITING

Research Site, Mar del Plata

M5500CCG

ACTIVE_NOT_RECRUITING

Research Site, Mendoza

B1878FNR

COMPLETED

Research Site, Quilmes

B1646EBJ

RECRUITING

Research Site, San Fernando

T4000IAR

COMPLETED

Research Site, San Miguel de Tucumán

89030-101

COMPLETED

Research Site, Blumenau

18618-686

RECRUITING

Research Site, Botucatu

71681-603

COMPLETED

Research Site, Brasília

80440-220

COMPLETED

Research Site, Curitiba

9061-000

RECRUITING

Research Site, Porto Alegre

91010-006

RECRUITING

Research Site, Porto Alegre

22061-080

COMPLETED

Research Site, Rio de Janeiro

09750-420

RECRUITING

Research Site, São Bernardo do Campo

01323-903

WITHDRAWN

Research Site, São Paulo

01409-001

ACTIVE_NOT_RECRUITING

Research Site, São Paulo

05403-000

COMPLETED

Research Site, São Paulo

T5A 4L8

RECRUITING

Research Site, Edmonton

T8L 0N2

RECRUITING

Research Site, Sherwood Park

L1S 2J5

RECRUITING

Research Site, Ajax

N1H 6J2

RECRUITING

Research Site, Guelph

K0C 2K0

RECRUITING

Research Site, Winchester

H3T 1E2

RECRUITING

Research Site, Montreal

G1G 3Y8

RECRUITING

Research Site, Québec

G1V 4G5

RECRUITING

Research Site, Québec

010010

ACTIVE_NOT_RECRUITING

Research Site, Hohhot

030001

COMPLETED

Research Site, Taiyuan

054047

RECRUITING

Research Site, Rionegro

625 00

COMPLETED

Research Site, Brno

586 33

WITHDRAWN

Research Site, Jihlava

377 01

RECRUITING

Research Site, Jindřichův Hradec

460 63

RECRUITING

Research Site, Liberec

779 00

ACTIVE_NOT_RECRUITING

Research Site, Olomouc

337 01

COMPLETED

Research Site, Rokycany

00290

RECRUITING

Research Site, Helsinki

06108

COMPLETED

Research Site, Halle

00168

RECRUITING

Research Site, Roma

07100

RECRUITING

Research Site, Sassari

078-8510

COMPLETED

Research Site, Asahikawa-shi

103-0022

WITHDRAWN

Research Site, Chūōku

426-8677

COMPLETED

Research Site, Fujieda-shi

819-8555

COMPLETED

Research Site, Fukuoka

430-8525

COMPLETED

Research Site, Hamamatsu

431-3192

WITHDRAWN

Research Site, Hamamatsu

734-8530

COMPLETED

Research Site, Hiroshima

820-8505

COMPLETED

Research Site, Iizuka-shi

173-8610

COMPLETED

Research Site, Itabashi-ku

438-8550

ACTIVE_NOT_RECRUITING

Research Site, Iwata-shi

920-8650

ACTIVE_NOT_RECRUITING

Research Site, Kanazawa

586-8521

COMPLETED

Research Site, Kawachinagano-shi

651-0072

COMPLETED

Research Site, Kobe

515-8544

COMPLETED

Research Site, Matsusaka-shi

509-6134

COMPLETED

Research Site, Mizunami-shi

460-0001

COMPLETED

Research Site, Nagoya

080-0017

COMPLETED

Research Site, Obihiro

700-8558

COMPLETED

Research Site, Okayama

531-0073

COMPLETED

Research Site, Osaka

543-8555

COMPLETED

Research Site, Osaka

545-8586

COMPLETED

Research Site, Osaka

593-8304

WITHDRAWN

Research Site, Sakaishi

162-8655

ACTIVE_NOT_RECRUITING

Research Site, Shinjuku-ku

420-8630

COMPLETED

Research Site, Shizuoka

170-0003

COMPLETED

Research Site, Toshima-ku

560-8552

COMPLETED

Research Site, Toyonaka-shi

221-0855

COMPLETED

Research Site, Yokohama

223-0059

COMPLETED

Research Site, Yokohama

232-0024

COMPLETED

Research Site, Yokohama

03650

RECRUITING

Research Site, Benito Juárez

01710

RECRUITING

Research Site, México

5623EJ

RECRUITING

Research Site, Eindhoven

9713 GZ

RECRUITING

Research Site, Groningen

3844 DG

ACTIVE_NOT_RECRUITING

Research Site, Harderwijk

6419 PC

RECRUITING

Research Site, Heerlen

7207 AE

RECRUITING

Research Site, Zutphen

8025 AB

WITHDRAWN

Research Site, Zwolle

L18

WITHDRAWN

Research Site, Lima

LIMA 21

RECRUITING

Research Site, Lima

LIMA 31

WITHDRAWN

Research Site, Lima

Unknown

RECRUITING

Research Site, Iloilo City

15-044

ACTIVE_NOT_RECRUITING

Research Site, Bialystok

85-796

ACTIVE_NOT_RECRUITING

Research Site, Bydgoszcz

40-648

ACTIVE_NOT_RECRUITING

Research Site, Katowice

30-033

ACTIVE_NOT_RECRUITING

Research Site, Krakow

20-412

ACTIVE_NOT_RECRUITING

Research Site, Lublin

27-400

ACTIVE_NOT_RECRUITING

Research Site, Ostrowiec Świętokrzyski

14-100

ACTIVE_NOT_RECRUITING

Research Site, Ostróda

60-693

ACTIVE_NOT_RECRUITING

Research Site, Poznan

61-578

WITHDRAWN

Research Site, Poznan

35-205

ACTIVE_NOT_RECRUITING

Research Site, Rzeszów

41-208

ACTIVE_NOT_RECRUITING

Research Site, Sosnowiec

53-301

ACTIVE_NOT_RECRUITING

Research Site, Wroclaw

54-239

WITHDRAWN

Research Site, Wroclaw

4835-235

RECRUITING

Research Site, Guimarães

1649-035

ACTIVE_NOT_RECRUITING

Research Site, Lisbon

1998-018

RECRUITING

Research Site, Lisbon

4454-509

RECRUITING

Research Site, Matosinhos Municipality

2600-009

RECRUITING

Research Site, Vila Franca de Xira

4434-502

WITHDRAWN

Research Site, Vila Nova de Gaia

050159

ACTIVE_NOT_RECRUITING

Research Site, Bucharest

05505

WITHDRAWN

Research Site, Seoul

06591

RECRUITING

Research Site, Seoul

07061

RECRUITING

Research Site, Seoul

143-729

RECRUITING

Research Site, Seoul

06800

RECRUITING

Research Site, Mérida

413 46

RECRUITING

Research Site, Gothenburg

222 22

RECRUITING

Research Site, Lund

205 02

WITHDRAWN

Research Site, Malmo

06620

RECRUITING

Research Site, Ankara

BD9 6RJ

RECRUITING

Research Site, Bradford

NN17 2UR

RECRUITING

Research Site, Corby

NN18 9EZ

RECRUITING

Research Site, Corby

EN3 4GS

WITHDRAWN

Research Site, Enfield

HP11 2QW

RECRUITING

Research Site, High Wycombe

HA6 2RN

RECRUITING

Research Site, Northwood

PR2 9QB

RECRUITING

Research Site, Preston

BD18 3SA

RECRUITING

Research Site, Shipley

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY