Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

509

Participants

Timeline

Start Date

May 31, 2023

Primary Completion Date

January 29, 2025

Study Completion Date

March 26, 2028

Conditions
Small Cell Lung Cancer (SCLC)
Interventions
DRUG

Tarlatamab

Tarlatamab will be administered as an IV infusion.

DRUG

Lurbinectedin

Lurbinectedin will be administered per local SOC.

DRUG

Topotecan

Topotecan will be administered per local SOC.

DRUG

Amrubicin

Amrubicin will be administered per local SOC.

Trial Locations (223)

9

Beaumont Hospital, Dublin

1083

Semmelweis Egyetem, Budapest

1121

Orszagos Koranyi Pulmonologiai Intezet, Budapest

1211

Hopitaux universitaires de Geneve, Geneva

1708

Freiburg Spital, Fribourg

2000

Sanatorio Parque SA, Rosario

2045

Reformatus Pulmonologiai Centrum, Törökbálint

2100

Rigshospitalet, Copenhagen

2170

Liverpool Hospital, Liverpool

2298

Calvary Mater Newcastle Hospital, Waratah

2800

Komarom-Esztergom Varmegyei Szent Borbala Korhaz, Tatabánya

3004

The Alfred Hospital, Melbourne

3168

Monash Medical Centre, Clayton

3200

Matrai Gyogyintezet, Gyöngyös

3500

Universitaetsklinikum Krems, Krems

Jessa Ziekenhuis - Campus Virga Jesse, Hasselt

7000

Kantonsspital Graubuenden, Chur

8000

Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz, Székesfehérvár

8036

Medizinische Universitaet Graz, Graz

8401

Kantonsspital Winterthur, Winterthur

8800

AZ Delta Campus Rumbeke, Roeselare

9000

Universitair Ziekenhuis Gent, Ghent

9007

Kantonsspital Sankt Gallen, Sankt Gallen

9100

Vitaz campus Sint-Niklaas Moerland, Sint-Niklaas

10002

National Taiwan University Hospital, Taipei

10016

New York University Grossman School of Medicine and New York University Langone Hospitals, New York

Perlmutter Cancer Center at New York University Langone Hospital----Long Island, New York

10021

Memorial Sloan Kettering Cancer Center, New York

10043

Azienda Ospedaliera Universitaria San Luigi Gonzaga, Orbassano

10408

National Cancer Center, Goyang-si Gyeonggi-do

11217

Taipei Veterans General Hospital, Taipei

11522

Saint Savas Hospital, Athens

11526

Henry Dunant Hospital Center, Athens

11527

Thoracic General Hospital Of Athens Sotiria, Athens

11528

Alexandra Hospital, Athens

11768

Northport Veterans Affairs Medical Center, Northport

13353

Charite Universitaetsmedizin Berlin, Campus Virchow, Berlin

13620

Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do

13915

Centre Hospitalier Universitaire Nord, Marseille

15006

Complexo Hospitalario Universitario A Coruna Hospital Teresa Herrera, A Coruña

16132

Ospedale Policlinico San Martino IRCCS, Genova

20070

Pamukkale Universitesi Tip Fakultesi Hastanesi, Denizli

21565

Gachon University Gil Hospital, Incheon

22927

LungenClinic Grosshansdorf GmbH, Großhansdorf

23298

Virginia Commonwealth University, Richmond

24125

Humanitas Gavazzeni, Bergamo

25100

Hospital Tengku Ampuan Afzan, Kuantan

26443

Olympion Therapeftirio General Clinic Of Patras, Pátrai

28040

Fundacion Jimenez Diaz, Madrid

Hospital Clinico San Carlos, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28222

Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda

28644

Chungbuk National University Hospital, Cheongju Chungbuk

29011

Hospital Regional Universitario de Malaga, Málaga

30009

Shanxi Province Cancer Hospital, Taiyuan

31059

Centre Hospitalier Universitaire de Toulouse - Hopital Larrey, Toulouse

34214

Bagcilar Medipol Mega Universite Hastanesi, Istanbul

34722

Goztepe Prof Dr Suleyman Yalcin Sehir Hastanesi, Istanbul

35033

Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou, Rennes

35100

Ege Universitesi Tip Fakultesi Hastanesi, Izmir

35575

Izmir Ekonomi Universitesi Medical Point Hastanesi, Izmir

36604

University of South Alabama Mitchell Cancer Institute, Mobile

37920

University of Tennessee Medical Center Knoxville, Knoxville

38120

Baptist Cancer Center, Memphis

38700

Centre Hospitalier Universitaire de Grenoble - Hopital Nord Michallon, Grenoble

40705

Veterans General Hospital - Taichung, Taichung

41501

Pikeville Medical Center, Pikeville

44033

Ulsan University Hospital, Ulsan

44280

Inonu Universitesi Turgut Ozal Tip Merkezi, Malatya

45147

Universitaetsklinikum Essen, Essen

45640

coi Centro Oncologico Internacional sapi de cv, Tlajomulco de Zúñiga

46202

Indiana University, Indianapolis

47014

Istituto Romagnolo per lo Studio dei Tumori Dino Amadori, Meldola (FC)

48106

Trinity Health Saint Joseph Mercy Ann Arbor, Ann Arbor

50009

Hospital Clinico Universitario Lozano Blesa, Zaragoza

50937

Universitaetsklinikum Koeln, Cologne

52242

University of Iowa, Iowa City

52727

Gyeongsang National University Hospital, Jinju

53226

The Medical College of Wisconsin, Milwaukee

55236

Saint Luke Hospital, Thessaloniki

55455

University of Minnesota Cancer Center, Minneapolis

57001

European Interbalkan Medical Center, Thessaloniki

57104

Sanford Oncology Clinic and Pharmacy, Sioux Falls

58102

Sanford Roger Maris Cancer Center, Fargo

59037

Centre Hospitalier Régional Universitaire de Lille - Institut Coeur Poumon, Lille

59100

University Malaya Medical Centre, Kuala Lumpur

60611

Northwestern University, Chicago

60612

University of Illinois Chicago, Chicago

65212

University of Missouri Health Care, Columbia

67091

Centre Hospitalier Universitaire de Strasbourg - Nouvel Hopital Civil, Strasbourg

69008

Centre Leon Berard, Lyon

69495

Centre Hospitalier Lyon Sud, Pierre-Bénite

70376

Robert-Bosch-Krankenhaus, Stuttgart

70403

National Cheng Kung University Hospital, Tainan City

70808

Our Lady of the Lake Cancer Institute, Baton Rouge

71500

University Hospital of Heraklion, Heraklion - Crete

72205

University of Arkansas for Medical Sciences, Little Rock

75005

Institut Curie, Paris

80756

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

82130

Asklepios Fachkliniken Muenchen Gauting, Gauting

87042

Centre Hospitalier Regional Universitaire de Limoges - Hopital Dupuytren, Limoges

88100

Azienda Ospedaliera Universitaria Renato Dulbecco, Catanzaro

90404

University of California Los Angeles, Santa Monica

91010

Summit Medical Group, Overlook Oncology Center, Summit

93586

Sarawak General Hospital, Kuching

94805

Gustave Roussy, Villejuif

97078

Universitaetsklinikum Wuerzburg, Würzburg

98026

Swedish Cancer Institute Medical Oncology, Edmonds

99508

Alaska Oncology and Hematology, Anchorage

100010

Beijing Tongren Hospital affiliated to Capital Medical University, Beijing

100142

Beijing Cancer Hospital, Beijing

101149

Beijing Chest Hospital, Capital Medical University, Beijing

130012

Jilin Cancer Hospital, Changchun

150000

Affiliated Cancer Hospital of Harbin Medical University, Harbin

168583

National Cancer Centre Singapore, Singapore

200030

Shanghai Chest Hospital, Shanghai

200032

Fudan University Shanghai Cancer Center, Shanghai

200542

Centrul de Oncologie Sf Nectarie SRL, Craiova

225009

Subei Peoples Hospital, Yangzhou

230022

Anhui Chest Hospital, Hefei

250013

Jinan Central Hospital, Jinan

250117

Shandong Tumor Hospital, Jinan

264200

Weihai Municipal Hospital, Weihai

276034

Linyi Cancer Hospital, Linyi

300131

Tianjin Peoples Hospital, Tianjin

300239

SC Oncomed SRL, Timișoara

308433

Tan Tock Seng Hospital, Singapore

310003

The First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou

The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou

310005

Zhejiang Cancer Hospital, Hangzhou

317099

Taizhou Hospital of Zhejiang Province, Taizhou

325015

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou

330006

The First Affiliated Hospital of Nanchang University, Nanchang

350001

Fujian Medical University Union Hospital, Fuzhou

350011

Fujian Cancer Hospital, Fuzhou

350025

Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou

400015

Institutul Oncologic Prof Dr Ion Chiricuta Cluj-Napoca, Cluj-Napoca

400037

The Second Affiliated Hospital of Army Medical University, PLA, Chongqing

400042

Army Special Medical Center of Peoples Liberation Army, Chongqing

410013

Hunan Cancer Hospital, Changsha

430022

Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan

430030

Tongji Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan

510060

Sun Yat-Sen University Cancer Center, Guangzhou

529030

Jiangmen Central Hospital, Jiangmen

610041

West China Hospital of Sichuan University, Chengdu

700483

Institutul Regional de Oncologie Iasi, Iași

3109601

Rambam Medical Center, Haifa

4428164

Meir Medical Center, Kfar Saba

4941492

Rabin Medical Center, Petah Tikva

9112001

Hadassah Ein-Kerem Medical Center, Jerusalem

C1431FWO

Cemic, Ciudad Autonoma de Buenos Aires

B1629ODT

Hospital Universitario Austral, Pilar

X5004BAL

Sociedad de Beneficencia Hospital Italiano, Córdoba

R8500ACE

Clinica Viedma, Viedma

C1122AAL

Instituto Argentino de Diagnostico y Tratamiento IADT, Buenos Aires

X5000JHQ

Sanatorio Allende, Córdoba

40050-410

Hospital Santa Izabel, Salvador

Unknown

Instituto de Ensino e Pesquisa do Hospital da Bahia, Salvador

59075-740

Liga Norte-Riograndense Contra O Cancer, Natal

98700-000

Oncosite Centro de Pesquisa Clinica Em Oncologia Ltda, Ijuí

90610-000

Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre

76834-899

Hospital de Amor da Amazonia, Porto Velho

15090-000

Hospital de Base de Sao Jose do Rio Preto, São José do Rio Preto

01323-900

Beneficencia Portuguesa de Sao Paulo - Bp, São Paulo

04502-001

Oncologia Rede D Or, São Paulo

22793-080

Instituto Coi, Rio de Janeiro

01246-000

Instituto do Cancer do Estado de Sao Paulo Octavio Frias de Oliveira Icesp, São Paulo

N6A 5W9

London Health Sciences Centre, London

M5G 2M9

Princess Margaret Cancer Centre, Toronto

050000

The 4th Hospital of Hebei Medical University, Shijiazhuang

625 00

Fakultni nemocnice Brno, Brno

656 53

Masarykuv onkologicky ustav, Brno

779 00

Fakultni nemocnice Olomouc, Olomouc

703 00

Nemocnice Agel Ostrava-Vitkovice as, Ostrava-Vitkovice

128 08

Vseobecna fakultni nemocnice v Praze, Prague

01307

Universitaetsklinikum Dresden, Dresden

00144

Azienda Ospedaliera San Giovanni Addolorata, Roma

460-0001

National Hospital Organization Nagoya Medical Center, Nagoya

464-8681

Aichi Cancer Center, Nagoya

277-8577

National Cancer Center Hospital East, Kashiwa-shi

791-0280

National Hospital Organization Shikoku Cancer Center, Matsuyama

830-0011

Kurume University Hospital, Kurume-shi

003-0804

National Hospital Organization Hokkaido Cancer Center, Sapporo

673-8558

Hyogo Cancer Center, Akashi-shi

241-8515

Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center, Yokohama

981-0914

Sendai Kousei Hospital, Sendai

951-8566

Niigata Cancer Center Hospital, Niigata

700-8558

Okayama University Hospital, Okayama

573-1191

Kansai Medical University Hospital, Hirakata-shi

541-8567

Osaka International Cancer Institute, Osaka

589-8511

Kindai University Hospital, Osakasayama-shi

350-1298

Saitama Medical University International Medical Center, Hidaka-Shi

411-8777

Shizuoka Cancer Center, Sunto-gun

113-8431

Juntendo University Hospital, Bunkyo-ku

104-0045

National Cancer Center Hospital, Chuo-ku

135-8550

The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Koto-ku

641-8510

Wakayama Medical University Hospital, Wakayama

03100

Health Pharma Professional Research SA de CV, Mexico City

03810

Oncare, Mexico City

9713 GZ

Universitair Medisch Centrum Groningen, Groningen

2333 ZA

Leids Universitair Medisch Centrum, Leiden

3015 GD

Erasmus Medisch Centrum, Rotterdam

3584 CX

Universitair Medisch Centrum Utrecht, Utrecht

43-360

Centrum Pulmonologii i Torakochirurgii w Bystrej, Bystra

31-826

Szpital Specjalistyczny imienia Ludwika Rydygiera w Krakowie Sp zoo, Krakow

60-569

Wielkopolskie Centrum Pulmonologii i Torakochirurgii imienia Eugenii i Janusza Zeylandow, Poznan

1500-650

Hospital da Luz, SA, Lisbon

1998-018

Hospital Cuf Descobertas, Lisbon

4464-513

Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano, Matosinhos Municipality

4100-180

Hospital Cuf porto, Porto

03722

Severance Hospital Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

06591

The Catholic University of Korea Seoul St Marys Hospital, Seoul

08003

Hospital del Mar, Barcelona

08035

Hospital Universitari Vall d Hebron, Barcelona

08041

Hospital de la Santa Creu i Sant Pau, Barcelona

06520

Memorial Ankara Hastanesi, Ankara

06560

Gazi Universitesi Saglik Arastirma ve Uygulama Merkezi Gazi Hastanesi, Ankara

06800

Ankara Bilkent Sehir Hastanesi, Ankara

NW1 2PG

University College London Hospital, London

SE1 9RT

Guys Hospital, London

M20 4BX

Christie Hospital, Manchester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY

NCT05740566 - Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer | Biotech Hunter | Biotech Hunter