Trial to Compare Different Strategies of Mean Arterial Pressure Management During Cardiopulmonary By-pass

NARecruitingINTERVENTIONAL
Enrollment

900

Participants

Timeline

Start Date

May 3, 2021

Primary Completion Date

December 31, 2023

Study Completion Date

December 31, 2026

Conditions
Heart; Surgery, Heart, Functional Disturbance as Result
Interventions
OTHER

Management of mean arterial pressure during cardiopulmonary by-pass in cardiac surgery interventions. The MAP will be mantained in the range of values of each study arm

"The patients enrolled to elective cardiac surgeries will be evaluated during a pre-operative outpatient visit and widely informed about the chance to participate in the study. When patients undergo to the elective surgery general anaesthesia is administered and CPB is installed. The nominal flow for each patient will be 2,4 l/min/m2.~To keep the MAP values around those corresponding to the randomized group, vasodilator (if MAP overcomes the assigned MAP value) or vasoconstrictor drugs will be used (if MAP value is lower than the assigned group). The following drugs will be used: nitroglicerine at incremental dose of 0,01 mcg/kg/min for a vasodilator effect and norepinephrine at incremental dose of 0,01 mcg/kg/min for a vasoconstrictor effect"

Trial Locations (1)

37126

RECRUITING

Azienda Ospedaliera Universitaria Integrata di Verona, Verona

All Listed Sponsors
lead

Azienda Ospedaliera Universitaria Integrata Verona

OTHER