Vasopressin vs. Epinephrine During Neonatal Cardiopulmonary Resuscitation

PHASE1RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

November 27, 2023

Primary Completion Date

December 31, 2025

Study Completion Date

January 31, 2026

Conditions
Cardiac Arrest Neonatal
Interventions
DRUG

Vasopressin

"Vasopressin group Vasopressin will be via umbilical vein catheter (0.4 IU/kg per dose - first line) or alternatively via an endotracheal tube (8 IU/kg) every three to five minutes as needed with a maximum of two doses if there is no ROSC \[2,3\] After that, the clinical team must convert to give epinephrine (0.02 mg/kg per dose) as long as CPR is ongoing."

DRUG

Epinephrine

"Epinephrine group Epinephrine will be administered according to current resuscitation guidelines either via umbilical vein catheter (0.02 mg/kg per dose) or via endotracheal tube (0.1 mg/kg) every three to five minutes as needed\[2,3\]. Chest compressions and epinephrine will be continued until ROSC."

Trial Locations (1)

T5H 3V9

RECRUITING

Royal Alexandra Hospital, Edmonton

All Listed Sponsors
lead

University of Alberta

OTHER