Nab-paclitaxel Versus Sb-taxanes As First-Line Treatment in Advanced Ovarian Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

538

Participants

Timeline

Start Date

November 27, 2023

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2027

Conditions
Epithelial Ovarian Carcinoma Stage IIIEpithelial Ovarian Carcinoma Stage IVFallopian Tube Carcinoma Stage IIIFallopian Tube Carcinoma Stage IVPrimary Peritoneal Carcinoma Stage IIIPrimary Peritoneal Carcinoma Stage IV
Interventions
DRUG

nab-paclitaxel combined with carboplatin

"Nab-Paclitaxel/carboplatin q3weeks Nab-Paclitaxel 260 mg/m² IV followed by carboplatin AUC(area under the curve) 5 IV Day1 Repeat every 21 days x 6 cycles Nab-Paclitaxel/carboplatin weekly Dose-dense Nab-Paclitaxel 100 mg/m2 IV followed by carboplatin AUC(area under the curve)2 IV Davs 1. 8, and 15 ·Repeat every 21 days x 6 cycles Paclitaxel 175 mg/m² IV followed by carboplatin AUC(area under the curve)5 IV Day·1Repeat every 21 days x 6 cycles~Paclitaxel weekly/carboplatin weekly Paclitaxel 60 mg/m2 followed by carboplatin AUC(area under the curve)2 IV Days 1.8. and 15: repeat every 21 days 6 cycles (18 weeks)"

Trial Locations (11)

250012

NOT_YET_RECRUITING

Qilu Hospital of Shandong University, Ji'nan

310006

RECRUITING

Yaxia Chen, Hangzhou

Unknown

NOT_YET_RECRUITING

Sun Yat-Sen University Cancer Hospital, Guangzhou

NOT_YET_RECRUITING

Sir Run Run Hospital, Hangzhou

NOT_YET_RECRUITING

The First Affiliated Hospital of Medical College of Zhejiang University, Hangzhou

NOT_YET_RECRUITING

The Second Affiliated Hospital of Medical College of Zhejiang University, Hangzhou

NOT_YET_RECRUITING

Zhejiang Cancer Hospital, Hangzhou

NOT_YET_RECRUITING

Ningbo women's and children's Hospital, Ningbo

NOT_YET_RECRUITING

The No, 1 People's Hospital of Ningbo, Ningbo

NOT_YET_RECRUITING

The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou

NOT_YET_RECRUITING

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou

All Listed Sponsors
collaborator

Jiaxing Maternity and Child Health Care Hospital

OTHER

collaborator

Zhejiang University

OTHER

collaborator

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

collaborator

First Affiliated Hospital of Wenzhou Medical University

OTHER

collaborator

Second Affiliated Hospital of Wenzhou Medical University

OTHER

collaborator

Sun Yat-sen University

OTHER

collaborator

Qilu Hospital of Shandong University

OTHER

collaborator

Ningbo No. 1 Hospital

OTHER

collaborator

Ningbo Women & Children's Hospital

OTHER

collaborator

Sir Run Run Shaw Hospital

OTHER

lead

Women's Hospital School Of Medicine Zhejiang University

OTHER