Yale Steroid Enhanced Versus Exparel Nerveblock TKA Part 2

PHASE2RecruitingINTERVENTIONAL
Enrollment

66

Participants

Timeline

Start Date

February 7, 2023

Primary Completion Date

September 30, 2027

Study Completion Date

March 31, 2028

Conditions
Total Knee ReplacementKnee Arthroplasty
Interventions
DRUG

Bupivacaine-Liposomal Bupivacaine

A medication mixture of 40 ml (20 ml LB and 20 ml 0.25% plain bupivacaine) will be prepared, of which 20 ml will be used in Adductor canal block, 10 ml will be used in iPACK block and 5 ml each will be used in medial upper and lateral upper genicular nerve block, respectively.

DRUG

Bupivacaine -Dexamethasone Sodium Phosphate-Methylprednisolone Acetate

A medication mixture of 40 ml (40 ml 0.25% plain bupivacaine, 10 mg DEX and 80 mg MPA) will be prepared, of which 20 ml will be used in Adductor canal block, 10 ml will be used in iPACK block and 5 ml each will be used in medial upper and lateral upper genicular nerve block, respectively.

Trial Locations (2)

06520

RECRUITING

Yale New Haven Hospital Saint Raphael Campus, New Haven

RECRUITING

Yale New Haven Hospital York Street Campus, New Haven

All Listed Sponsors
collaborator

Department of Anesthesiology Faculty Development Fund

UNKNOWN

lead

Yale University

OTHER