Comparison Between Rituximab Plus Zanubrutinib Versus Rituximab Monotherapy in Untreated SMZL Patients

PHASE3RecruitingINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

May 21, 2024

Primary Completion Date

May 31, 2029

Study Completion Date

May 31, 2029

Conditions
Splenic Marginal Zone Lymphoma
Interventions
DRUG

Rituximab

Truxima concentrate for solution for infusion 500 mg/50 ml

DRUG

Zanubrutinib

Zanubrutinib 80 mg hard capsules

Trial Locations (56)

3010

RECRUITING

INSELSPITAL, Bern University Hospital, Bern

6500

RECRUITING

Oncology Institute of Southern Switzerland, Bellinzona

20122

RECRUITING

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan

20132

RECRUITING

IRCCS Ospedale San Raffaele, Milan

20162

RECRUITING

ASST Grande Ospedale Metropolitano Niguarda, Milan

21100

RECRUITING

Ospedale di Circolo e Fondazione Macchi - ASST dei Sette Laghi, Varese

25123

RECRUITING

ASST Spedali Civili di Brescia, Brescia

28100

RECRUITING

Azienda Ospedaliero Universitaria Maggiore della Carità, Novara

33076

RECRUITING

Institut Bergonié, Bordeaux

38043

RECRUITING

CHU de Grenoble, Grenoble

40138

RECRUITING

IRCCS AOU di Bologna, Bologna

42123

RECRUITING

USL-IRCCS of Reggio Emilia, Arcispedale Santa Maria Nuova, Reggio Emilia

47014

RECRUITING

"IRCCS IRST Istituto Romagnolo per lo Studio dei Tumori Dino Amadori", Meldola

48121

RECRUITING

Ospedale Santa Maria delle Croci, Ravenna

53100

NOT_YET_RECRUITING

Policlinico Santa Maria alle Scotte, Siena

54511

RECRUITING

CHRU Nancy Brabois, Vandœuvre-lès-Nancy

69495

RECRUITING

Hôpital Lyon-Sud, Pierre-Bénite

70124

RECRUITING

IRCCS Istituto Tumori Giovanni Paolo II, Bari

75475

RECRUITING

Hôpital Saint Louis, Paris

90146

RECRUITING

Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello, Palermo

95123

RECRUITING

A.O.U. Policlinico G. Rodolico-S. Marco, Catania

Unknown

RECRUITING

Medical University of Vienna, Vienna

NOT_YET_RECRUITING

Aarhus University Hospital, Aarhus

RECRUITING

IRCCS Policlinico San Matteo, Pavia

NOT_YET_RECRUITING

"Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli", Reggio Calabria

RECRUITING

Oslo University Hospital, Oslo

NOT_YET_RECRUITING

St Olavs Hospital, Trondheim

RECRUITING

Hospedal Clinic de Barcelona, Barcelona

RECRUITING

Hospital del Mar, Barcelona

NOT_YET_RECRUITING

Hospital Vall d'Hebron, Barcelona

RECRUITING

Istitut Català d'Oncologia, Hospital Duran i Reynals, Barcelona

RECRUITING

Hospital Universitario Cruces, Bilbao

RECRUITING

Hospital Virgen Arrixaca, El Palmar

RECRUITING

Clinica Universidad de Navarra, Madrid

RECRUITING

Hospital 12 De Octubre, Madrid

RECRUITING

Hospital Gregorio Marañón, Madrid

RECRUITING

Hospital Ramon y Cajal, Madrid

RECRUITING

Clinica Universidad de Navarra, Pamplona

RECRUITING

Hospital De Salamanca, Salamanca

RECRUITING

Hospital De Donostia, San Sebastián

RECRUITING

Hospital Clinico De Valencia, Valencia

RECRUITING

Hospital Universitario Miguel Servet, Zaragoza

NOT_YET_RECRUITING

Karolinska University Hospital, Stockholm

B95 SS

NOT_YET_RECRUITING

Birmingham Hearthland Hospital, Birmingham

BH7 7DW

RECRUITING

University Hospitals Dorset, Bournemouth

CF14 4XW

RECRUITING

University Hospital of Wales, Cardiff

G12 0YN

RECRUITING

Hospital Beatson West of Scotland Cancer Centre, Glasgow

LE1 5WW

RECRUITING

Leicester Royal Infirmary, Leicester

L7 8YA

RECRUITING

Clatterbridge Cancer Centre, Liverpool

NW1 2PG

RECRUITING

University College London Hospitals, London

SE1 9RT

RECRUITING

Guy's Hospital - Guy's and St. Thomas' NHS Foundation Trust, London

M20 4BX

RECRUITING

The Christie, Manchester

OX3 7LE

RECRUITING

Churchill Hospital, Oxford

PL6 8DH

RECRUITING

Derriford Hospital, Plymouth

SO16 6YD

NOT_YET_RECRUITING

University Hospitals Southampton, Southampton

SM2 5PT

RECRUITING

The Royal Marsden NHS Foundation Trust, Sutton

All Listed Sponsors
lead

International Extranodal Lymphoma Study Group (IELSG)

OTHER