A Clinical Study of BCD-217 (Nurulimab + Prolgolimab) Followed by Anti-PD-1 Compared to Anti-PD-1 Monotherapy as First-Line Treatment in Subjects With Unresectable/Metastatic Melanoma

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

270

Participants

Timeline

Start Date

August 2, 2022

Primary Completion Date

June 20, 2024

Study Completion Date

July 31, 2025

Conditions
MelanomaMelanoma (Skin)Melanoma Stage IIIMelanoma Stage IVMelanoma UnresectableMelanoma MetastaticMelanoma Advanced
Interventions
BIOLOGICAL

BCD-217

Subject recieves BCD-217 0.2 mL/kg, which is equivalent to 1 mg/kg nurulimab + 3 mg/kg prolgolimab, as an intravenous infusion once every 3 weeks (Q3W) simultaneously with placebo, a total of 4 intravenous infusions. Beginning with the 5th infusion, subjects are switched to prolgolimab 1 mg/kg monotherapy once every 2 weeks (Q2W).

BIOLOGICAL

BCD-100

Subject recieves prolgolimab 3 mg/kg as an intravenous infusion once every 3 weeks (Q3W) simultaneously with placebo, a total of 4 intravenous infusions. Beginning with the 5th infusion, subjects are switched to prolgolimab 1 mg/kg monotherapy once every 2 weeks (Q2W).

BIOLOGICAL

Placebo

Placebo

Trial Locations (63)

150054

"State Regional Budgetary Healthcare Institution Regional Clinical Oncology Hospital of the Yaroslavl Region", Yaroslavl

156005

"Regional Goverment Budgetary Healthcare State Kostroma Oncology Center", Kostroma

188663

"LLC Clinical Trials", Saint Petersburg

190013

"JSC Modern Medical Technologies", Saint Petersburg

220013

"Healthcare Institution Minsk City Clinical Cancer Center", Minsk

354057

Oncology Dispensary 2, Sochi

357500

"LLC New Clinic", Pyatigorsk

454087

Chelyabinsk Regional Clinical Center for Oncology and Nuclear Medicine, Chelyabinsk

603006

"Nizhny Novgorod Region State Budgetary Healthcare Facility Clinical Diagnostics Center", Nizhny Novgorod

Unknown

"Healthcare Institution Bobruisk Interdistrict Oncological Dispensary", Babruysk

"Healthcare Institution Brest Regional Oncological Dispensary", Brest

"Health care institution Grodno University Clinic", Grodno

"Health Institution Gomel Regional Clinical Oncology Center", Homyel

"State Institution Republican Scientific and Practical Center of Oncology and Medical Radiology named after A.I. N.N. Alexandrov", Lesnoy

"State Institution Mogilev Regional Oncological Dispensary", Mogilev

"Healthcare Institution Vitebsk Regional Clinical Oncology Center", Vitebsk

Fortis Hospital, Faridabad

Kasturba Medical College and Hospital, Mangalore

TATA Memorial Hospital, Mumbai

HealthCare Global Enterprises Ltd, NCHRI Cancer Center, Nagpur

HealthCare Global Enterprises Ltd Manavata cancer Centre, Nashik

Sankalp Superspeciality Hospital, Nashik

All India Institute of Medical Science, New Delhi

Deenanath Mangeshkar Hospital & Research Center, Pune

PDEAS Ayurved Rugnalaya & Steriling Multispeciality Hospital, Pune

Horizon Mulitispeciality Hospital, Sangli

Shalby Hospital, Surat

Kiran Multispeciality hospital &Research, Sūrat

Arkhangelsk Clinical Oncology Dispensary, Arkhangelsk

"Regional State Budgetary Institution of Health Care Altai Regional Oncological Dispensary", Barnaul

"Limited Liability Company EVIMED", Chelyabinsk

"Private healthcare institution Clinical hospital RZD-Medicine of the city of Chelyabinsk", Chelyabinsk

State budgetary healthcare institution Leningrad Regional Clinical Hospital, Gatchina

"State Autonomous Health Institution Republican Clinical Oncology Dispensary of the Ministry of Health of the Republic of Tatarstan named after Professor M.Z. Sigal", Kazan'

"State budgetary health care institution Kuzbass clinical oncological dispensary named after M.S. Rappoport", Kemerovo

"State Budgetary Institution of Healthcare Leningrad Regional Clinical Oncological Dispensary named after V.I. L.D. Romana", Kuz'molovskiy

"Russian Cancer Research Center named after N.N. Blokhin of the Ministry of Health of the Russian Federation", Moscow

Branch of Hadassah Medical LTD Limited Liability Company, Moscow

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow

"Joint Stock Company K31 City", Moscow

"JSC Medsi Group", Moscow

Moscow City Oncology Hospital No. 62, Moscow

"State budgetary health care institution of the city of Moscow City Clinical Oncology Hospital No. 1 of the Department of Health of the City of Moscow", Moscow

"State Budgetary Institution of Healthcare of the City of Moscow Moscow Multidisciplinary Clinical Center Kommunarka of the Department of Health of the City of Moscow", Moscow

"LLC DobroMed", Novosibirsk

"State Budgetary Healthcare Institution Novosibirsk Regional Clinical Oncology Center of the Novosibirsk Region", Novosibirsk

"Federal State Budgetary Institution National Medical Research Center for Radiology of the Ministry of Health of the Russian Federation", Obninsk

"Budgetary Healthcare Institution of Omsk Region Clinical Oncology Center", Omsk

"Federal State Budgetary Institution National Medical Research Center of Oncology named after N.N. Petrov of the Ministry of Health of the Russian Federation (FSBI N.N. Petrov National Medical Research Center of Oncology of the Ministry of Health of Ru", Pesochnyy

City Hospital #40, Kurortny district, Saint Petersburg

"Federal State Budgetary Educational Institution of Higher Education Saint Petersburg State University", Saint Petersburg

Federal State Budgetary Health Institution St. Petersburg Clinical Hospital of the Russian Academy of Sciences, Saint Petersburg

"Limited Liability Company EuroCityClinic", Saint Petersburg

"Limited Liability Company Oncological Research Center", Saint Petersburg

"Limited Liability Company Stepmed Clinic", Saint Petersburg

"Limited Liability Company Strategic Medical Systems", Saint Petersburg

"LLC AV medical group", Saint Petersburg

N.N. Petrov National Medicine Research Center of oncology, Saint Petersburg

Private Medical Institution Evromedservis, Saint Petersburg

"State budgetary health care institution St. Petersburg Clinical Scientific and Practical Center of Specialized Medical Assistance (Oncological)", Saint Petersburg

"Private institution educational organization of higher education Medical University Reaviz", Samara

"Federal State Educational Institution of Higher Professional Education Mordovia State University N.P. Ogareva ", Saransk

"State Health Care Institution Volgograd Regional Clinical Oncology Dispensary № 1", Volgograd

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Biocad

INDUSTRY

NCT05732805 - A Clinical Study of BCD-217 (Nurulimab + Prolgolimab) Followed by Anti-PD-1 Compared to Anti-PD-1 Monotherapy as First-Line Treatment in Subjects With Unresectable/Metastatic Melanoma | Biotech Hunter | Biotech Hunter