Algorithm-based Tailoring of Dual Antiplatelet Therapy to Improve Outcomes Following Percutaneous Coronary Interventions

NARecruitingINTERVENTIONAL
Enrollment

2,788

Participants

Timeline

Start Date

June 27, 2023

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2028

Conditions
Percutaneous Coronary InterventionPlatelet Aggregation InhibitorsCoronary Artery Disease
Interventions
OTHER

Algorithm-guided DAPT duration

"PRECISE-DAPT score ≥25~* Chronic Coronary Syndromes (CCS): Aspirin + clopidogrel for 1 month, followed by clopidogrel monotherapy~* Acute Coronary Syndromes (ACS): Aspirin + ticagrelor for 1 month, followed by ticagrelor monotherapy~PRECISE-DAPT score \<25:~* Non-complex CCS: Aspirin + clopidogrel for 6 months, followed by clopidogrel monotherapy~* Non-complex ACS: Aspirin + potent P2Y12 inhibitor for 6 months, followed by potent P2Y12 inhibitor monotherapy~* Complex CCS or ACS: Aspirin + P2Y12 inhibitor for 12 months, followed by P2Y12 inhibitor monotherapy (potent P2Y12 inhibitor mandatory for ACS)"

OTHER

Standard-of-care DAPT duration

DAPT strategy at the operators´ discretion in accordance with applicable guidelines

Trial Locations (3)

3010

RECRUITING

Department of Cardiology, Bern University Hospital, Bern

78000

RECRUITING

University Clinical Center of the Republic of Srpska, Banja Luka

00184

RECRUITING

UOC Cardiologia San Giovanni Addolorata Hospital, Roma

All Listed Sponsors
lead

Insel Gruppe AG, University Hospital Bern

OTHER