A Phase 2 Study to Assess the Safety and Efficacy of Intravitreal ONL1204 Ophthalmic Solution in Subjects With Mac-off Retinal Detachment

PHASE2CompletedINTERVENTIONAL
Enrollment

136

Participants

Timeline

Start Date

April 4, 2023

Primary Completion Date

February 21, 2024

Study Completion Date

February 21, 2024

Conditions
Rhegmatogenous Retinal Detachment - Macula Off
Interventions
DRUG

ONL1204 Ophthalmic Solution

ONL1204 Ophthalmic Solution at one of two doses delivered via intravitreal injection

DRUG

Sham treatment

Sham injection is performed by touching the eye surface with a syringe without a needle

Trial Locations (36)

13088

Retina Vitreous Surgeons of CNY, PC, Liverpool

14620

Retina Associates of Western NY, PC, Rochester

16507

Erie Retina Research, LLC, Erie

21740

Cumberland Valley Retina Consultants, Hagerstown

29169

Palmetto Retina Center, LLC, West Columbia

29456

Charleston Neuroscience Institute, Ladson

30060

Marietta Eye Clinic, Marietta

32216

Florida Retina Institute, Jacksonville

32503

Retina Specialty Institute, Pensacola

33544

Retina Specialists of Tampa, Wesley Chapel

33711

Retina Vitreous Associates of Florida, St. Petersburg

33805

Florida Retina Consultants, Lakeland

34239

Sarasota Retina Institute, Sarasota

37421

Southeastern Retina Associates, Chattanooga

38138

Charles Retina Institute, Germantown

45202

Velocity Clinical Research, Inc., Cincinnati

46290

Midwest Eye Institute, Carmel

48105

University of Michigan Kellogg Eye Center, Ann Arbor

55905

Mayo Clinic, Rochester

57108

Opthalmology Ltd, Sioux Falls

60126

Retina Associates, Ltd., Elmhurst

Retina Associates, Ltd, Elmhurst

63144

The Retina Institute, St Louis

77384

Retina Consultants of Texas, The Woodlands

77707

Retina Consultants of Texas, Beaumont

78215

San Antonio Eye Center, San Antonio

78503

Valley Retina Institute, P.A., McAllen

78705

Austin Research Center for Retina, Austin

79606

Retina Research Institute of Texas, Abilene

85020

Associated Retina Consultants, Phoenix

85704

Retina Associates SW PC, Tucson

91006

Win Retina, Arcadia

91204

Global Research Management, Inc., Glendale

92647

Salehi Retina Institute, Inc., Huntington Beach

97239

Oregon Health & Science University - Casey Eye Institute, Portland

98383

Retina Center NW, PLLC, Silverdale

Sponsors

Lead Sponsor

All Listed Sponsors
lead

ONL Therapeutics

INDUSTRY

NCT05730218 - A Phase 2 Study to Assess the Safety and Efficacy of Intravitreal ONL1204 Ophthalmic Solution in Subjects With Mac-off Retinal Detachment | Biotech Hunter | Biotech Hunter