Volatile Organic Compound Assessment in Pancreatic Ductal Adenocarcinoma

RecruitingOBSERVATIONAL
Enrollment

1,005

Participants

Timeline

Start Date

December 15, 2022

Primary Completion Date

April 30, 2026

Study Completion Date

April 30, 2026

Conditions
PDAC - Pancreatic Ductal AdenocarcinomaPancreatic Cancer
Interventions
DIAGNOSTIC_TEST

Breath test

Patients must be fasted for a minimum of six hours prior to sample collection. For patients undergoing surgery or a procedure (e.g. endoscopy), breath samples must be obtained pre-operatively / prior to the administration of sedation, anaesthetic or other pharmacological agents.

DIAGNOSTIC_TEST

Collection of matched samples of breath, biofluids and pancreatic tissue

In accordance with routine clinical practices, patients will be fasted for a minimum of six hours prior to surgery. Exhaled breath, saliva, blood and urine will be collected immediately prior to surgery (before induction of general anaesthesia). Pancreatic tissue samples and duodenal aspirate which will be collected upon resection of the pancreatic specimen.

Trial Locations (1)

Unknown

RECRUITING

Imperial College Healthcare NHS Trust, London

All Listed Sponsors
collaborator

Pancreatic Cancer UK

OTHER

collaborator

Imperial College Healthcare NHS Trust

OTHER

collaborator

Royal Free Hospital NHS Foundation Trust

OTHER

collaborator

Liverpool University Hospitals NHS Foundation Trust

OTHER_GOV

collaborator

The Leeds Teaching Hospitals NHS Trust

OTHER

collaborator

Sheffield Teaching Hospitals NHS Foundation Trust

OTHER

collaborator

University Hospital Southampton NHS Foundation Trust

OTHER

collaborator

Royal Surrey County Hospital NHS Foundation Trust

OTHER

collaborator

University Hospital Birmingham NHS Foundation Trust

OTHER

collaborator

Manchester University NHS Foundation Trust

OTHER_GOV

collaborator

Newcastle-upon-Tyne Hospitals NHS Trust

OTHER

collaborator

Swansea Bay University Health Board

OTHER

collaborator

Dorset County Hospital NHS Foundation Trust

OTHER_GOV

collaborator

North Tees and Hartlepool NHS Foundation Trust

OTHER

collaborator

University Hospital Plymouth NHS Trust

OTHER

collaborator

Barts & The London NHS Trust

OTHER

collaborator

Milton Keynes University Hospital NHS Foundation Trust

OTHER_GOV

collaborator

Buckinghamshire Healthcare NHS Trust

OTHER

collaborator

Southern Health

OTHER

lead

Imperial College London

OTHER