taVNS or TMS or Both for Depression

NARecruitingINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

March 14, 2023

Primary Completion Date

June 1, 2026

Study Completion Date

July 1, 2026

Conditions
Depression
Interventions
DEVICE

Vagus Nerve Stimulation

All taVNS sessions will use the following parameters: 25Hz, 500us pulse width, on for 7 seconds, off for 12 seconds.The length of VNS treatment sessions will be identical to TMS treatment sessions and will have the same 30 minute break between each treatment session. These treatments (active or sham) will be administered to participants each treatment day, for a total of 6 different treatment days, but only 4 are active.

DEVICE

Transcranial Magnetic Stimulation

Participants will receive 20 trains of 30 pulses each for a total of 600 pulses per session. We will repeat this for 6 sessions each day, with at least 30 minutes between each session. These treatments (active or sham) will be administered to participants each treatment day, for a total of 6 different treatment days, but only 4 are active, so participants will get 24 TMS sessions over the course.

Trial Locations (1)

29412

RECRUITING

Medical University of South Carolina Institute of Psychiatry, Charleston

All Listed Sponsors
lead

Medical University of South Carolina

OTHER