Deep rTMS Modulating Insula Synaptic Density and Smoking Behavior in Schizophrenia

NARecruitingINTERVENTIONAL
Enrollment

38

Participants

Timeline

Start Date

April 4, 2023

Primary Completion Date

August 31, 2027

Study Completion Date

August 31, 2028

Conditions
SchizophreniaSmoking CessationTobacco Use
Interventions
DEVICE

Active deep transcranial magnetic stimulation (dTMS)

"First, the investigators will find the position of the right abductor pollicis brevis (APB) motor cortex, finding the minimal motor threshold (MT) required for its activation, which determines the strength of the pulses. After determining the MT, dTMS stimulation is applied 6 cm anterior to the motor hot spot, at 120% of the MT. The target threshold is built toward gradually. During the first treatment, participants receive stimulation at 100% of the MT. During the second treatment, stimulation intensity increases to 110% of the MT. Beginning at the third treatment and continuing onward, participants receive treatment at 120% of the MT for the course of the treatment."

DEVICE

Sham dTMS

Sham group will go through the same procedure. The only difference is that the sham card does not deliver stimulation.

Trial Locations (1)

11794

RECRUITING

Stony Brook University, Stony Brook

All Listed Sponsors
collaborator

National Institute on Drug Abuse (NIDA)

NIH

lead

Stony Brook University

OTHER