Testing the Effectiveness of an Anti-cancer Drug, Triapine, When Used With Targeted Radiation-based Treatment (Lutetium Lu 177 Dotatate), Compared to Lutetium Lu 177 Dotatate Alone for Metastatic Neuroendocrine Tumors

PHASE2RecruitingINTERVENTIONAL
Enrollment

94

Participants

Timeline

Start Date

August 30, 2023

Primary Completion Date

November 30, 2025

Study Completion Date

November 30, 2025

Conditions
Metastatic Neuroendocrine Tumor
Interventions
PROCEDURE

Biospecimen Collection

Undergo collection of blood samples

PROCEDURE

Computed Tomography

Undergo CT

DRUG

Lutetium Lu 177 Dotatate

Given IV

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Triapine

Given PO

Trial Locations (25)

10065

SUSPENDED

NYP/Weill Cornell Medical Center, New York

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

32610

RECRUITING

University of Florida Health Science Center - Gainesville, Gainesville

33136

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

RECRUITING

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33180

RECRUITING

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

RECRUITING

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

40536

RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

53718

RECRUITING

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison

53792

RECRUITING

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

60611

RECRUITING

Northwestern University, Chicago

77030

RECRUITING

M D Anderson Cancer Center, Houston

77079

SUSPENDED

MD Anderson West Houston, Houston

77384

SUSPENDED

MD Anderson in The Woodlands, Conroe

77478

SUSPENDED

MD Anderson in Sugar Land, Sugar Land

77573

SUSPENDED

MD Anderson League City, League City

84112

RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

91010

RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

92612

RECRUITING

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine

92868

RECRUITING

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

95817

RECRUITING

University of California Davis Comprehensive Cancer Center, Sacramento

08903

RECRUITING

Rutgers Cancer Institute of New Jersey, New Brunswick

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH