377
Participants
Start Date
February 14, 2023
Primary Completion Date
July 12, 2024
Study Completion Date
May 22, 2028
Pembrolizumab Formulated with Berahyaluronidase Alfa
Pembrolizumab (+) Berahyaluronidase alfa SC will be administered for squamous and nonsquamous NSCLC as per the schedule specified in arm; participants may be eligible for second course.
Pemetrexed
Pemetrexed 500 mg/m² by IV Infusion will be administered for nonsquamous NSCLC as per the schedule specified in arm.
Cisplatin
Cisplatin 75 mg/m² by IV Infusion will be administered for nonsquamous and squamous NSCLC as per the schedule specified in arm.
Carboplatin
Carboplatin AUC 5 mg/mL/min in nonsquamous and AUC 6 mg/mL/min in squamous NSCLC will be administered as per the schedule specified in arm.
Paclitaxel
Paclitaxel 200 mg/m² by IV Infusion will be administered for squamous NSCLC as per the schedule specified in arm.
Nab-paclitaxel
Nab-paclitaxel 100 mg/m² by IV Infusion will be administered for squamous NSCLC as per the schedule specified in arm.
Pembrolizumab
Pembrolizumab by IV Infusion will be administered for squamous and nonsquamous NSCLC as per the schedule specified in arm; participants may be eligible for second course.
Filgrastim
Filgrastim will be administered as per the schedule specified for the arm.
Pegylated filgrastim
Pegylated filgrastim will be administered as per the schedule specified for the arm.
National Taiwan University Cancer Center (NTUCC) ( Site 4205), Taipei City
National Cheng Kung University Hospital ( Site 4202), Tainan City
Kaohsiung Medical University Chung-Ho Memorial Hospital ( Site 4207), Kaohsiung City
Semmelweis Egyetem-Pulmonológiai Klinika ( Site 2104), Budapest
Országos Korányi Pulmonológiai Intézet-VI. Tüdöbelosztály és Bronchológia ( Site 2100), Budapest
Reformatus Pulmonologiai Centrum ( Site 2105), Törökbálint
Medical Oncology Centre of Rosebank ( Site 2907), Johannesburg
Sandton Oncology Medical Group (Pty) Ltd-Research ( Site 2900), Sandton
The Oncology Centre ( Site 2901), Durban
Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház-Onkologiai Kozpont ( Site 2103), Szolnok
Bacs-Kiskun Megyei Korhaz-Onkoradiologiai Kozpont ( Site 2102), Kecskemét
CANCERCARE LANGENHOVEN DRIVE ONCOLOGY CENTRE ( Site 2903), Port Elizabeth
Cape Town Oncology Trials ( Site 2902), Cape Town
National Taiwan University Hospital-Oncology ( Site 4204), Taipei
Chulalongkorn University ( Site 4301), Bangkok
Division of Medical Oncology, Siriraj H ( Site 4303), Bangkok
CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 2404), Santiago de Compostela
Hospital Universitario Juan Ramon Jimenez-Oncología Medica ( Site 2402), Huelva
HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON-ONCOLOGY ( Site 2401), Madrid
Centre Hospitalier de Cornouaille Quimper - Concarneau ( Site 2600), Quimper
Mid Florida Hematology and Oncology Center ( Site 0010), Orange City
Clermont Oncology Center ( Site 0018), Clermont
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 2502), Istanbul
I.E.U. Medical Point Hastanesi-Oncology ( Site 2507), Izmir
Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau ( Site 2602), Tours
Memorial Kayseri Hastanesi ( Site 2500), Kayseri
Hattiesburg Clinic Hematology/Oncology ( Site 0008), Hattiesburg
Mercy Health-Paducah Cancer Center ( Site 0006), Paducah
İnönü Üniversitesi Turgut Özal Tıp Merkezi-medical oncology depertmant ( Site 2503), Malatya
Franciscan Health Lafayette East ( Site 0020), Lafayette
Changhua Christian Hospital ( Site 4203), Changhua
Maharaj Nakorn Chiang Mai Hospital ( Site 4300), Chiang Mai
Orchard Healthcare Research Inc. ( Site 0011), Skokie
University of Illinois at Chicago-University of Illinois Cancer Center ( Site 0022), Chicago
Central Care Cancer Center - Bolivar ( Site 0017), Bolivar
Hopitaux Universitaires Paris Centre-Hopital Cochin ( Site 2603), Paris
E-Da hospital ( Site 4208), Kaohsiung City
Chang Gung Memorial Hospital at Kaohsiung ( Site 4200), Kaohsiung City
St. Joseph's Hospital and Medical Center-Dignity Health Cancer Institute ( Site 0023), Phoenix
Songklanagarind hospital ( Site 4302), Songkhla
Beijing Cancer hospital-intrathoratic deparmtment II ( Site 4510), Beijing
Beijing Peking Union Medical College Hospital-pneumology department ( Site 4501), Beijing
Beijing Chest Hospital,Capital Medical University ( Site 4511), Beijing
Fudan University Shanghai Cancer Center-Oncology ( Site 4512), Shanghai
Centrul de Oncologie Sfantul Nectarie-Medical ( Site 2301), Craiova
Anhui Provincial Hospital-Cancer Chemotherapy Department ( Site 4503), Hefei
Tianjin Chest Hospital ( Site 4518), Tianjin
Cabinet Medical Oncomed ( Site 2305), Timișoara
The First Affiliated Hospital, Zhejiang University-Respiratory Department ( Site 4514), Hangzhou
Taizhou Hospital of Zhejiang Province ( Site 4508), Linhai
The First Affiliated Hospital of Nanchang University-Respiratory Medicine Department ( Site 4515), Nanchang
Fujian Provincial Cancer Hospital ( Site 4517), Fuzhou
Institutul Oncologic-Oncologie Medicala ( Site 2302), Cluj-Napoca
Chongqing University Three Gorges Hospital ( Site 4516), Wanzhou
SC Radiotherapy Center Cluj SRL-Oncologie Medicala ( Site 2303), Florești
Shanxi Cancer Hospital ( Site 4521), Taiyuan
Union Hospital Tongji Medical College Huazhong University of Science and Technology-Medical Oncology ( Site 4502), Wuhan
Southern Medical University Nanfang Hospital-Depatrment of Respiratory and Critical Care Medicine ( Site 4519), Guangzhou
ShenZhen People's Hospital ( Site 4504), Shenzhen
Jiangmen Center Hospital ( Site 4509), Jiangmen
The First Affiliated Hospital of Xi'an Jiaotong University ( Site 4520), Xi'an
IC La Serena Research ( Site 1207), La Serena
Oncocentro Valdivia ( Site 1201), Valdivia
FALP-UIDO ( Site 1203), Santiago
Oncovida ( Site 1209), Santiago
Pontificia Universidad Catolica de Chile-Hemato-Oncology ( Site 1210), Santiago
Instituto Nacional del Cancer-CR Investigación ( Site 1211), Santiago
Bradfordhill-Clinical Area ( Site 1202), Santiago
Hospital Italiano de Buenos Aires-Clinical Oncology ( Site 1005), Ciudad Autonoma de Buenos Aires
Instituto de Investigaciones Clínicas Mar del Plata ( Site 1001), Mar del Plata
Instituto Argentino de Diagnóstico y Tratamiento (IADT) ( Site 1002), Buenos Aires
Instituto Alexander Fleming ( Site 1008), Buenos Aires
Clinica Adventista Belgrano-Oncology ( Site 1004), Buenos Aires
Sanatorio Parque ( Site 1003), Rosario
Hospital Italiano de Córdoba ( Site 1000), Córdoba
CRIO - CENTRO REGIONAL INTEGRADO DE ONCOLOGIA-Pesquisa Clínica ( Site 1102), Fortaleza
Hospital de Cancer de Pernambuco ( Site 1107), Recife
Hospital Nossa Senhora da Conceição-Centro Integrado de Pesquisa em Oncologia ( Site 1100), Porto Alegre
Instituto Joinvilense de Hematologia e Oncologia ( Site 1101), Joinville
A. C. Camargo Cancer Center ( Site 1106), São Paulo
MEDI-K ( Site 1403), Guatemala City
Private Practice- Dr. Rixci Augusto Lenin Ramírez ( Site 1404), Guatemala City
Centro Regional de Sub Especialidades Médicas SA ( Site 1401), Quetzaltenango
Centro Medico Integral De Cancerología (CEMIC) ( Site 1400), Quetzaltenango
Fujita Health University Hospital ( Site 4406), Toyoake
Kurume University Hospital ( Site 4412), Kurume
Gunma Prefectural Cancer Center ( Site 4416), Ōta
National Hospital Organization Hokkaido Cancer Center ( Site 4415), Sapporo
Kanagawa Cardiovascular and Respiratory Center ( Site 4404), Yokohama
Miyagi Cancer Center ( Site 4401), Natori-shi
Sendai Kousei Hospital ( Site 4400), Sendai
Kurashiki Central Hospital ( Site 4409), Kurashiki
Kansai Medical University Hospital ( Site 4408), Hirakata
Osaka Medical and Pharmaceutical University Hospital ( Site 4414), Takatsuki
Saitama Prefectural Cancer Center ( Site 4402), Kitaadachi-gun
Shizuoka Cancer Center ( Site 4405), Sunto-gun,
Tochigi Cancer Center ( Site 4417), Utsunomiya
Juntendo University Hospital ( Site 4413), Bunkyo-ku
National Hospital Organization Kyushu Medical Center ( Site 4411), Fukuoka
National Hospital Organization Kyushu Cancer Center ( Site 4410), Fukuoka
Osaka International Cancer Institute ( Site 4407), Osaka
Nippon Medical School Hospital ( Site 4403), Tokyo
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 2800), Warsaw
Warmińsko - Mazurskie Centrum Chorób Płuc w Olsztynie-Oddzial Onkologii z Pododdzialem Chemioterapii ( Site 2802), Olsztyn
Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie-Oddzial Dzienny Chemioterapii ( Site 2801), Koszalin
Steve Biko Academic Hospital-Medical Oncology ( Site 2904), Pretoria
Hospital Universitari Vall d'Hebron-Oncology ( Site 2400), Barcelona
Gulhane Egitim Arastirma Hastanesi-Oncology ( Site 2504), Ankara
Hacettepe Universite Hastaneleri-oncology hospital ( Site 2506), Ankara
Ankara City Hospital-Medical Oncology ( Site 2501), Ankara
Merck Sharp & Dohme LLC
INDUSTRY