BENTO - Bronchoscopic Lung Volume Reduction in Severe Emphysema Using Thermoablation

NARecruitingINTERVENTIONAL
Enrollment

224

Participants

Timeline

Start Date

April 24, 2024

Primary Completion Date

April 25, 2026

Study Completion Date

December 1, 2027

Conditions
Emphysema or Chronic Obstructive Pulmonary Disease
Interventions
DEVICE

InterVapor®-System

"The InterVapor System uses heated water vapor to ablate the airways and parenchyma within targeted regions of the lung. Lung remodeling occurs after an initial localized inflammatory response and a subsequent healing and repair. The remodeling of the tissue results in reductions in tissue and air volume in the targeted regions of the lung. The remodeled lung tissue does not re-inflate as a result of collateral ventilation.~The lung volume reduction of diseased hyper-inflated lung segments after InterVapor treatment is expected to increase elastic recoil by reducing the most compliant segments of the lung, decompressing segments of healthier lung allowing for alveolar recruitment, and improving the mechanical efficiency of the respiratory muscles. These mechanical changes are anticipated to improve pulmonary function, exercise capacity and quality of life."

Trial Locations (12)

13353

RECRUITING

Charité Campus Benjamin Franklin, Berlin

14089

RECRUITING

Gemeinschaftskrankenhaus Havelhöhe gGmbH Klinik für Anthroposophische Medizin, Berlin

18435

RECRUITING

Helios Hanseklinikum Stralsund, Stralsund

34376

RECRUITING

Lungenfachklinik Immenhausen, Immenhausen

53127

NOT_YET_RECRUITING

Universitätsklinikum Bonn, Medizinische Klinik und Poliklinik II, Bonn

58515

RECRUITING

KlinKlinikuim Lüdenscheid, Klinik für Pneumologie, internistische Intensivmedizin, Infektiologie und Schlafmedizin, Lüdenscheid

58675

RECRUITING

Lungenklinik Hemer, Hemer

63225

NOT_YET_RECRUITING

Asklepios Klinik Langen, Klinik für Innere Medizin III, Langen

69126

RECRUITING

Thoraxklinik University of Heidelberg, Heidelberg

97702

RECRUITING

Thoraxzentrum Bezirk Unterfranken, Münnerstadt

4542329

RECRUITING

Pneumologische Universitätsklinik Ruhrlandklinik, Essen

06120

RECRUITING

Universitätsklinikum Halle (Saale), Halle

All Listed Sponsors
lead

IHF GmbH - Institut für Herzinfarktforschung

OTHER