LUPUS-BEST - Treat-to-target in Systemic Lupus Erythematosus

NARecruitingINTERVENTIONAL
Enrollment

606

Participants

Timeline

Start Date

December 12, 2023

Primary Completion Date

April 30, 2026

Study Completion Date

September 30, 2026

Conditions
Systemic Lupus Erythematosus
Interventions
OTHER

Treat-to-target as a new treatment concept

After trial initiation, the study personnel in the intervention centers will receive a training on T2T and shared decision making (SDM). Patients in the intervention centers will receive 6-weekly visits for at least 24 weeks with therapeutic adjustments to achieve remission. In case of stable remission for 6 weeks at week 24, the patients switch to 12-weekly visits until the end of the trial at week 120. In case of flare, the patient switches to 6-weekly visits for 24 consecutive weeks. Pharmaceutical treatment decisions will be guided by current treatment standards and will be taken in accordance with SDM between patients and treating physicians.

Trial Locations (14)

10117

RECRUITING

Charité - Berlin University of Medicine, Berlin

24105

RECRUITING

UKSH Campus Kiel, Kiel

30625

RECRUITING

Medical University Hannover, Hanover

40225

RECRUITING

University Clinic Düsseldorf, Düsseldorf

44649

RECRUITING

Rheumazentrum Ruhrgebiet Herne, Ruhr University Bochum, Herne

45136

RECRUITING

Kliniken Essen Mitte, Essen, Essen

48149

RECRUITING

University Clinic Münster, Münster

55131

RECRUITING

University Clinic Mainz, Mainz

60590

RECRUITING

University Clinic Frankfurt, Frankfurt am Main

69120

RECRUITING

University Clinic Heidelberg, Heidelberg

79106

RECRUITING

University Clinic Freiburg, Freiburg im Breisgau

80336

RECRUITING

LMU Munich, Munich

91054

NOT_YET_RECRUITING

University Clinic Erlangen, Erlangen

01307

RECRUITING

University Medical Center TU Dresden, Dresden

All Listed Sponsors
collaborator

University Hospital Heidelberg

OTHER

collaborator

German Diabetes-Center, Leibniz-Institut in Düsseldorf

OTHER

collaborator

Lupus Erythematodes-Selbsthilfegemeinschaft e.V.

UNKNOWN

lead

Heinrich-Heine University, Duesseldorf

OTHER