Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

342

Participants

Timeline

Start Date

May 31, 2023

Primary Completion Date

April 15, 2032

Study Completion Date

April 15, 2032

Conditions
Heart FailureLeft Ventricular Systolic Dysfunction
Interventions
DRUG

Vericiguat tablet

2.5 mg or 5 mg or 10 mg vericiguat administered orally once daily in tablet form

DRUG

Vericiguat suspension

0.2 mg/mL or 1 mg/mL vericiguat administered orally once daily in suspension form

DRUG

Placebo tablet

Placebo for vericiguat administered orally once daily in tablet form

DRUG

Placebo suspension

Placebo for vericiguat administered orally once daily in suspension form

Trial Locations (94)

1023

RECRUITING

Auckland City Hospital ( Site 2000), Auckland

1096

RECRUITING

Gottsegen György Országos Kardiovaszkuláris Intézet-Gyermeksziv Kozpont ( Site 1300), Budapest

3000

RECRUITING

UZ Leuven ( Site 0300), Leuven

4000

RECRUITING

Centre Hospitalier Régional de la Citadelle ( Site 0302), Liège

7500

RECRUITING

TREAD Research ( Site 2700), Cape Town

7700

RECRUITING

Children's Heart Disease Research Unit ( Site 2704), Cape Town

9000

RECRUITING

UZ Gent ( Site 0301), Ghent

10032

RECRUITING

Columbia University Medical Center-Pediatric Cardiology ( Site 0016), New York

10467

RECRUITING

The Children's Hospital at Montefiore ( Site 0030), The Bronx

10700

RECRUITING

Faculty of Medicine Siriraj Hospital ( Site 3200), Bangkok

13005

RECRUITING

Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone ( Site 1003), Marseille

13353

RECRUITING

Deutsches Herzzentrum Berlin ( Site 1101), Berlin

14080

RECRUITING

Instituto Nacional de Cardiologia Ignacio Chavez ( Site 1804), México

15009

RECRUITING

Hospital Materno-Infantil Teresa Herrera ( Site 2905), A Coruña

15072

RECRUITING

Instituto Nacional Cardiovascular INCOR Carlos Peschiera Carrillo - EsSalud ( Site 2100), Jesús María

15224

RECRUITING

Children's Hospital of Pittsburgh ( Site 0010), Pittsburgh

16147

RECRUITING

IRCCS Istituto Giannina Gaslini ( Site 1603), Genoa

16150

RECRUITING

Hospital Universiti Sains Malaysia ( Site 1703), Kota Bharu

19104

RECRUITING

Children's Hospital of Philadelphia (CHOP) ( Site 0004), Philadelphia

20010

RECRUITING

Children's National Medical Center ( Site 0020), Washington D.C.

20129

RECRUITING

Centro de Atención e Investigación Clínica ( Site 1813), Aguascalientes

22185

RECRUITING

Skånes Universitetssjukhus Lund ( Site 3000), Lund

28007

RECRUITING

HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON ( Site 2904), Madrid

28046

RECRUITING

Hospital Universitario La Paz ( Site 2912), Madrid

30329

RECRUITING

Children's Healthcare of Atlanta - Arthur M. Blank Hospital ( Site 0001), Atlanta

30625

RECRUITING

Medizinische Hochschule Hannover ( Site 1108), Hanover

33520

RECRUITING

Tampereen yliopistollinen sairaala-Pediatric Early Phase Trials Unit ( Site 0900), Tampere

33600

RECRUITING

CHU Bordeaux Haut-Leveque ( Site 1000), Pessac

33701

RECRUITING

Johns Hopkins All Children's Hospital ( Site 0029), St. Petersburg

34668

RECRUITING

Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi ( Site 3302), Istanbul

35128

RECRUITING

Azienda Ospedale - Università Padova ( Site 1601), Padua

35210

RECRUITING

S.B.Ü. DR. BEHÇET UZ ÇOCUK HASTALIKLARI VE CERRAHİSİ EĞİTİM VE ARAŞTIRMA HASTANESİ ( Site 3303), Izmir

37000

RECRUITING

Morales Vargas Centro de Investigacion ( Site 1810), León

38103

RECRUITING

Le Bonheur Children's Hospital ( Site 0007), Memphis

40002

COMPLETED

Faculty of Medicine - Khon Kaen University ( Site 3202), Muang

41013

RECRUITING

HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO ( Site 2907), Seville

44093

RECRUITING

Centre Hospitalier Universitaire de Nantes - Hôpital Femme-Enfant-Adolescent Chu De Nantes ( Site 1002), Nantes

44195

RECRUITING

Cleveland Clinic-Cleveland Clinic Chidren's ( Site 0022), Cleveland

44690

RECRUITING

CINVEC Medica ( Site 1814), Guadalajara

45229

RECRUITING

Cincinnati Children's Hospital Medical Center ( Site 0034), Cincinnati

48109

RECRUITING

C.S. Mott Children's Hospital ( Site 0033), Ann Arbor

50139

RECRUITING

A.O.Universitaria Meyer ( Site 1600), Florence

50200

RECRUITING

Maharaj Nakorn Chiang Mai Hospital-Department of Pediatrics ( Site 3201), Chiang Mai

50300

RECRUITING

Hospital Tunku Azizah-Paediatric ( Site 1700), Kuala Lumpur

50400

RECRUITING

Institut Jantung Negara ( Site 1705), Kuala Lumpur

50612

RECRUITING

Pusan National University Yangsan Hospital ( Site 2802), Pusan

52763

RECRUITING

INVECORDIS S.C. ( Site 1808), Hacienda de Las Palmas

59037

RECRUITING

CHU Lille - Institut Coeur Poumon ( Site 1005), Lille

59100

RECRUITING

University Malaya Medical Centre ( Site 1701), Lembah Pantai

63110

RECRUITING

Washington University-Pediatric Cardiology/ St. Louis Children's Hospital ( Site 0006), St Louis

69120

RECRUITING

Universitaetsklinikum Heidelberg ( Site 1100), Heidelberg

75015

RECRUITING

Hôpital Universitaire Necker Enfants Malades ( Site 1001), Paris

75019

RECRUITING

Assistance Publique - Hopitaux de Paris (AP-HP) - Hopital Robert Debre - Centre Hospitalo Universita ( Site 1004), Paris

75235

RECRUITING

Children's Health-The Heart Center ( Site 0015), Dallas

79106

RECRUITING

Universitaetsklinikum Freiburg ( Site 1102), Freiburg im Breisgau

80045

RECRUITING

Children's Hospital Colorado ( Site 0012), Aurora

89440

RECRUITING

Centro de Estudios de Investigacion Metabolicos y Cardiovasculares ( Site 1800), Ciudad Madero

90095

RECRUITING

The Regents of the University of California - Los Angeles (UCLA Pediatrics) ( Site 0002), Los Angeles

91054

RECRUITING

Kinderklinik des Uni-Klinikums Erlangen ( Site 1104), Erlangen

92354

RECRUITING

Loma Linda University Health System ( Site 0008), Loma Linda

98105

RECRUITING

Seattle Children's Hospital-Cardiology/Fetal Therapy ( Site 0019), Seattle

110131

RECRUITING

Fundación Cardioinfantil Instituto de Cardiología ( Site 0603), Bogotá

119074

RECRUITING

National University Hospital-Paediatrics ( Site 2600), Singapore

229899

RECRUITING

KK Women's and Children's Hospital ( Site 2601), Singapore

760032

RECRUITING

Fundación Valle del Lili ( Site 0604), Santiago de Cali

760042

RECRUITING

Clínica Imbanaco S.A.S ( Site 0602), Santiago de Cali

04012-909

RECRUITING

Instituto Dante Pazzanese de Cardiology ( Site 0402), São Paulo

05403-000

RECRUITING

Incor - Instituto do Coracao ( Site 0400), São Paulo

T6G 2B7

RECRUITING

Stollery Children's Hospital ( Site 0501), Edmonton

J1H 5H4

RECRUITING

Centre intégré universitaire de santé et de services sociaux-Centre de recherche du CHUS ( Site 0502), Sherbrooke

054040

RECRUITING

Clinica Somer ( Site 0607), Rionegro

08001

RECRUITING

Ciensalud Ips S A S ( Site 0608), Barranquilla

DK-2100

RECRUITING

Rigshospitalet-BørneUngeAfdelingen ( Site 0800), Copenhagen

D12 N512

RECRUITING

Children's Health Ireland (CHI) at Crumlin ( Site 1400), Dublin

Kota Kinab

RECRUITING

Hospital Queen Elizabeth II ( Site 1706), Kota Kinabalu

04530

RECRUITING

Instituto Nacional de Pediatria ( Site 1803), Mexico City

3015 CN

RECRUITING

Erasmus Medisch Centrum ( Site 1900), Rotterdam

9713GZ

RECRUITING

University Medical Center Groningen ( Site 1901), Groningen

3584 CX

RECRUITING

Universitair Medisch Centrum Utrecht ( Site 1902), Utrecht

80-952

COMPLETED

Uniwersyteckie Centrum Kliniczne-Klinika Kardiologii Dziecięcej i Wad Wrodzonych Serca ( Site 2302), Gdansk

2790-134

RECRUITING

Unidade Local de Saude Lisboa Ocidental - Hospital de Santa Cruz ( Site 2401), Lisbon

1649-035

RECRUITING

Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 2402), Lisbon

4200-319

RECRUITING

Unidade Local de Saúde de São João ( Site 2403), Porto

03080

RECRUITING

Seoul National University Hospital ( Site 2803), Seoul

03722

RECRUITING

Severance Hospital, Yonsei University Health System ( Site 2800), Seoul

06351

RECRUITING

Samsung Medical Center ( Site 2801), Seoul

08950

RECRUITING

Hospital Sant Joan de Déu-Pediatric cardiology ( Site 2902), Esplugues de Llobregat

08035

RECRUITING

Hospital Universitari Vall d'Hebron ( Site 2903), Barcelona

171 76

RECRUITING

Astrid Lindgrens Barnsjukhus ( Site 3001), Stockholm

06230

RECRUITING

Hacettepe Universite Hastaneleri ( Site 3304), Ankara

06490

RECRUITING

Baskent Universitesi Ankara Hastanesi ( Site 3301), Ankara

06800

RECRUITING

Ankara Bilkent Şehir Hastanesi. ( Site 3300), Ankara

WC1N 3JH

RECRUITING

Great Ormond Street Hospital For Children NHS Foundation Trust ( Site 3401), London

NE7 7DN

RECRUITING

Freeman Hospital ( Site 3400), Newcastle upon Tyne

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY