Understanding Brain Mechanisms Involved in Autobiographical Memory

NARecruitingINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

April 25, 2022

Primary Completion Date

May 1, 2027

Study Completion Date

August 1, 2027

Conditions
Mild Cognitive ImpairmentAlzheimer DiseaseMemory Loss
Interventions
DEVICE

high-density electroencephalography (hdEEG)

EEG will be recorded with a 257-channel EEG system (Geodesic Sensor Net, MegStim). An EEG net is applied at once on the head with evenly spaced sensors that provide full scalp coverage, including the cheek, Ag/Ag-Cl electrodes that are interconnected by thin rubber bands and contain small sponges soaked with saline water that touches the participant's scalp surface directly. Net application takes about 10 min to derive impedances to \<30 kOhms. EEG is recorded with 1 kHz and band-pass filtered between 0.1-200 Hz. Vertex electrode Cz is used as an acquisition reference.

DEVICE

Transcranial alternating current stimulation (tACS)

tACS will be delivered by a battery-driven current stimulator Starstim SS32 (Neuroelectrics) through surface Ag/AgCl electrodes placed into holes of a neoprene cap corresponding to the international 10/20 EEG system. Gel (Parker Lab, Inc.) will be applied to optimize signal conductivity and lower impedance.

Trial Locations (1)

1202

RECRUITING

University of Geneva, Campus Biotech, Geneva

All Listed Sponsors
lead

Lucie Bréchet

OTHER