Testing the Use of BRAF-Targeted Therapy After Surgery and Usual Chemotherapy for BRAF-Mutated Colon Cancer

PHASE2/PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1

Participants

Timeline

Start Date

August 16, 2023

Primary Completion Date

June 1, 2034

Study Completion Date

June 1, 2034

Conditions
Colon AdenocarcinomaMicrosatellite Stable Colon CarcinomaStage IIB Colon Cancer AJCC V8Stage IIC Colon Cancer AJCC V8Stage III Colon Cancer AJCC V8
Interventions
DRUG

Encorafenib

Given PO

BIOLOGICAL

Cetuximab

Given IV

PROCEDURE

Biospecimen Collection

Undergo collection of blood samples

PROCEDURE

Computed Tomography

Undergo CT

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

OTHER

Patient Observation

Undergo observation per usual care

Trial Locations (202)

10065

Memorial Sloan Kettering Cancer Center, New York

10604

Memorial Sloan Kettering Westchester, East White Plains

11553

Memorial Sloan Kettering Nassau, Uniondale

11725

Memorial Sloan Kettering Commack, Commack

12801

Glens Falls Hospital, Glens Falls

13126

Upstate Cancer Center at Oswego, Oswego

13210

State University of New York Upstate Medical University, Syracuse

13215

SUNY Upstate Medical Center-Community Campus, Syracuse

13478

Upstate Cancer Center at Verona, Verona

14263

Roswell Park Cancer Institute, Buffalo

17822

Geisinger Medical Center, Danville

17837

Geisinger Medical Oncology-Lewisburg, Lewisburg

17901

Geisinger Cancer Services-Pottsville, Pottsville

18017

Lehigh Valley Hospital - Muhlenberg, Bethlehem

18103

Lehigh Valley Hospital-Cedar Crest, Allentown

18201

Geisinger Medical Center-Cancer Center Hazleton, Hazleton

18301

Pocono Medical Center, East Stroudsburg

18510

Community Medical Center, Scranton

18711

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

19713

Helen F Graham Cancer Center, Newark

Medical Oncology Hematology Consultants PA, Newark

19967

Beebe South Coastal Health Campus, Millville

19971

Beebe Health Campus, Rehoboth Beach

22908

University of Virginia Cancer Center, Charlottesville

25304

West Virginia University Charleston Division, Charleston

27534

Southeastern Medical Oncology Center-Goldsboro, Goldsboro

28054

CaroMont Regional Medical Center, Gastonia

28328

Southeastern Medical Oncology Center-Clinton, Clinton

28546

Southeastern Medical Oncology Center-Jacksonville, Jacksonville

29303

Spartanburg Medical Center, Spartanburg

29316

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29341

Gibbs Cancer Center-Gaffney, Gaffney

29379

MGC Hematology Oncology-Union, Union

29605

Prisma Health Cancer Institute - Butternut, Greenville

Prisma Health Cancer Institute - Faris, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29640

Prisma Health Cancer Institute - Easley, Easley

29650

Prisma Health Cancer Institute - Greer, Greer

29651

Gibbs Cancer Center-Pelham, Greer

29672

Prisma Health Cancer Institute - Seneca, Seneca

30097

Emory Johns Creek Hospital, Johns Creek

30308

Emory University Hospital Midtown, Atlanta

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

Emory Saint Joseph's Hospital, Atlanta

43623

Toledo Clinic Cancer Centers-Toledo, Toledo

44111

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44122

South Pointe Hospital, Warrensville Heights

44124

Hillcrest Hospital Cancer Center, Mayfield Heights

44131

Cleveland Clinic Cancer Center Independence, Independence

44136

Cleveland Clinic Cancer Center Strongsville, Strongsville

44195

Cleveland Clinic Foundation, Cleveland

44691

Cleveland Clinic Wooster Family Health and Surgery Center, Wooster

44710

Aultman Health Foundation, Canton

44870

North Coast Cancer Care, Sandusky

44906

Cleveland Clinic Cancer Center Mansfield, Mansfield

45331

Miami Valley Cancer Care and Infusion, Greenville

45373

Upper Valley Medical Center, Troy

45409

Miami Valley Hospital, Dayton

Premier Blood and Cancer Center, Dayton

45415

Miami Valley Hospital North, Dayton

45459

Miami Valley Hospital South, Centerville

46307

Northwest Cancer Center - Main Campus, Crown Point

46311

Northwest Oncology LLC, Dyer

46312

Saint Catherine Hospital, Indianapolis

46321

The Community Hospital, Munster

Women's Diagnostic Center - Munster, Munster

46342

Northwest Cancer Center - Hobart, Hobart

Saint Mary Medical Center, Hobart

46383

Northwest Cancer Center - Valparaiso, Valparaiso

48044

Henry Ford Saint John Hospital - Macomb Medical, Macomb

48106

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

Huron Gastroenterology PC, Ypsilanti

48114

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

Trinity Health Medical Center - Brighton, Brighton

48118

Chelsea Hospital, Chelsea

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48154

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

Trinity Health Medical Center - Canton, Canton

48197

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48503

Cancer Hematology Centers - Flint, Flint

Genesee Hematology Oncology PC, Flint

Genesys Hurley Cancer Institute, Flint

Hurley Medical Center, Flint

48601

MyMichigan Medical Center Saginaw, Saginaw

50023

Mission Cancer and Blood - Ankeny, Ankeny

50309

Mission Cancer and Blood - Des Moines, Des Moines

52403

Mercy Hospital, Cedar Rapids

Oncology Associates at Mercy Medical Center, Cedar Rapids

53066

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

53149

ProHealth D N Greenwald Center, Mukwonago

53188

UW Cancer Center at ProHealth Care, Waukesha

54017

Cancer Center of Western Wisconsin, New Richmond

54166

ThedaCare Cancer Care - Shawano, Shawano

54401

Aspirus Regional Cancer Center, Wausau

54409

Langlade Hospital and Cancer Center, Antigo

54449

Marshfield Medical Center-Marshfield, Marshfield

54451

Aspirus Medford Hospital, Medford

54476

Marshfield Medical Center - Weston, Weston

54481

Aspirus Cancer Care - Stevens Point, Stevens Point

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54494

Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids

54501

Aspirus Cancer Care - James Beck Cancer Center, Rhinelander

54548

Marshfield Medical Center - Minocqua, Minocqua

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

54911

ThedaCare Regional Cancer Center, Appleton

54923

ThedaCare Cancer Care - Berlin, Berlin

54956

ThedaCare Regional Medical Center - Neenah, Neenah

54981

ThedaCare Cancer Care - Waupaca, Waupaca

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55407

Abbott-Northwestern Hospital, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

56601

Sanford Joe Lueken Cancer Center, Bemidji

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

58122

Sanford Broadway Medical Center, Fargo

Sanford Roger Maris Cancer Center, Fargo

58501

Sanford Bismarck Medical Center, Bismarck

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

59711

Community Hospital of Anaconda, Anaconda

59715

Bozeman Health Deaconess Hospital, Bozeman

59804

Community Medical Center, Missoula

59901

Logan Health Medical Center, Kalispell

60026

Northwestern Medicine Glenview Outpatient Center, Glenview

60030

Northwestern Medicine Grayslake Outpatient Center, Grayslake

60045

Northwestern Medicine Lake Forest Hospital, Lake Forest

60115

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60134

Northwestern Medicine Cancer Center Delnor, Geneva

60451

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

Northwestern Medicine Orland Park, Orland Park

University of Chicago Medicine-Orland Park, Orland Park

60504

Rush - Copley Medical Center, Aurora

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60560

Rush-Copley Healthcare Center, Yorkville

60611

Northwestern University, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

61021

Illinois CancerCare-Dixon, Dixon

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

61571

Illinois CancerCare - Washington, Washington

61615

Illinois CancerCare-Peoria, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

61801

Carle Cancer Center, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

Cancer Care Center of O'Fallon, O'Fallon

62321

Illinois CancerCare-Carthage, Carthage

62401

Carle Physician Group-Effingham, Effingham

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Springfield Memorial Hospital, Springfield

63703

Saint Francis Medical Center, Cape Girardeau

73104

University of Oklahoma Health Sciences Center, Oklahoma City

75080

UT Southwestern Clinical Center at Richardson/Plano, Richardson

75235

Parkland Memorial Hospital, Dallas

75237

UT Southwestern Simmons Cancer Center - RedBird, Dallas

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76104

UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth

83301

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83605

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83687

Saint Alphonsus Cancer Care Center-Nampa, Nampa

Saint Luke's Cancer Institute - Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

Saint Luke's Cancer Institute - Boise, Boise

83814

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

96701

Hawaii Cancer Care - Westridge, ‘Aiea

Pali Momi Medical Center, ‘Aiea

96706

The Queen's Medical Center - West Oahu, ‘Ewa Beach

96813

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu

Queen's Cancer Cenrer - POB I, Honolulu

Queen's Medical Center, Honolulu

Straub Clinic and Hospital, Honolulu

96817

Queen's Cancer Center - Kuakini, Honolulu

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97914

Saint Alphonsus Cancer Care Center-Ontario, Ontario

98026

Swedish Cancer Institute-Edmonds, Edmonds

98029

Swedish Cancer Institute-Issaquah, Issaquah

98122

Swedish Medical Center-First Hill, Seattle

03756

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

07920

Memorial Sloan Kettering Basking Ridge, Basking Ridge

07748

Memorial Sloan Kettering Monmouth, Middletown

07645

Memorial Sloan Kettering Bergen, Montvale

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Alliance for Clinical Trials in Oncology

OTHER

NCT05710406 - Testing the Use of BRAF-Targeted Therapy After Surgery and Usual Chemotherapy for BRAF-Mutated Colon Cancer | Biotech Hunter | Biotech Hunter