Pharmacological Agents for Chronic Spinal Cord Injury (SCI)

PHASE1RecruitingINTERVENTIONAL
Enrollment

28

Participants

Timeline

Start Date

January 20, 2023

Primary Completion Date

July 30, 2025

Study Completion Date

July 30, 2025

Conditions
Spinal Cord Injuries
Interventions
DRUG

CPH + hand training

Following a 10-minute rest after baseline measurements a single dose pharmacological agent or placebo will be administered, in blinded fashion, with up to 180 mL of noncarbonated water, on an empty stomach (minimum 2 hours without food). After capsule ingestion, participants will spend 50 minutes performing hand task-oriented training, resting for 10 minutes before undertaking post-intervention outcome measurements.

DRUG

CD-LD + hand training

Following a 10-minute rest after baseline measurements a single dose pharmacological agent or placebo will be administered, in blinded fashion, with up to 180 mL of noncarbonated water, on an empty stomach (minimum 2 hours without food). After capsule ingestion, participants will spend 50 minutes performing hand task-oriented training, resting for 10 minutes before undertaking post-intervention outcome measurements.

DRUG

ATX + hand training

Following a 10-minute rest after baseline measurements a single dose pharmacological agent or placebo will be administered, in blinded fashion, with up to 180 mL of noncarbonated water, on an empty stomach (minimum 2 hours without food). After capsule ingestion, participants will spend 50 minutes performing hand task-oriented training, resting for 10 minutes before undertaking post-intervention outcome measurements.

DRUG

Placebo + hand training

Following a 10-minute rest after baseline measurements a single dose pharmacological agent or placebo will be administered, in blinded fashion, with up to 180 mL of noncarbonated water, on an empty stomach (minimum 2 hours without food). After capsule ingestion, participants will spend 50 minutes performing hand task-oriented training, resting for 10 minutes before undertaking post-intervention outcome measurements.

Trial Locations (1)

10468

RECRUITING

James J. Peters Veterans Affairs Medical Center, The Bronx

Sponsors
All Listed Sponsors
lead

Bronx VA Medical Center

FED