NCT05702229 - Novel Combinations in Participants With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma | Biotech Hunter

Enrollment

240

Participants

Timeline

Start Date

January 16, 2023

Primary Completion Date

July 3, 2026

Study Completion Date

July 1, 2027

Conditions

Gastric Cancer

Interventions

DRUG

Rilvegostomig

an anti PD-1 and anti-TIGIT bispecific antibody; IV infusion

DRUG

Volrustomig

an anti PD-1 and anti CTLA-4 bispecific antibody; IV infusion

DRUG

FOLFOX

5-fluorouracil 400 mg/m\^2 IV, oxaliplatin 85 mg/m\^2, leucovorin 400 mg/m\^2 (or levoleucovorin 200 mg/m\^2 when locally preferred and available), day 1, 5-fluorouracil 1200 mg/m\^2 IV 24 h day 1-2

DRUG

XELOX

capecitabine 1000 mg/m\^2 BID, days 1 to 14, oxaliplatin 130 mg/m\^2, day 1

DRUG

AZD7789

an anti PD 1 and anti TIM 3 bispecific antibody; IV infusion

DRUG

AZD0901

an anti Claudin18.2 ADC; IV infusion

DRUG

5-Fluorouracil

5-FU, IV infusion, Q3W

DRUG

Capecitabine

Oral take, Q3W

Trial Locations (44)

300

RECRUITING

Research Site, Hsinchu

333

RECRUITING

Research Site, Taoyuan District

404

RECRUITING

Research Site, Taichung

10002

RECRUITING

Research Site, Taipei

10028

WITHDRAWN

Research Site, New York

10065

RECRUITING

Research Site, New York

10469

WITHDRAWN

Research Site, The Bronx

11042

WITHDRAWN

Research Site, New Hyde Park

11210

WITHDRAWN

Research Site, New York

11259

RECRUITING

Research Site, Taipei

11967

WITHDRAWN

Research Site, Shirley

15212

WITHDRAWN

Research Site, Pittsburgh

28007

RECRUITING

Research Site, Madrid

28040

RECRUITING

Research Site, Madrid

39008

RECRUITING

Research Site, Santander

49503

RECRUITING

Research Site, Grand Rapids

70403

RECRUITING

Research Site, Tainan City

70817

RECRUITING

Research Site, Baton Rouge

80756

RECRUITING

Research Site, Kaohsiung City

90017

RECRUITING

Research Site, Los Angeles

90095

WITHDRAWN

Research Site, Los Angeles

100142

RECRUITING

Research Site, Beijing

150081

RECRUITING

Research Site, Harbin

230031

RECRUITING

Research Site, Hefei

310003

RECRUITING

Research Site, Hangzhou

310020

RECRUITING

Research Site, Hangzhou

430079

RECRUITING

Research Site, Wuhan

450052

RECRUITING

Research Site, Zhengzhou

650118

COMPLETED

Research Site, Kunming

750004

RECRUITING

Research Site, Yinchuan

104-0045

RECRUITING

Research Site, Chūōku

227-8577

RECRUITING

Research Site, Kashiwa

411-8777

RECRUITING

Research Site, Sunto-gun

03080

RECRUITING

Research Site, Seoul

03722

RECRUITING

Research Site, Seoul

05505

RECRUITING

Research Site, Seoul

06351

RECRUITING

Research Site, Seoul

08035

RECRUITING

Research Site, Barcelona

03202

RECRUITING

Research Site, Elche(Alicante)

08908

RECRUITING

Research Site, L'Hospitalet de Llobregat

EH4 2XU

WITHDRAWN

Research Site, Edinburgh

LS9 7TF

RECRUITING

Research Site, Leeds

EC1M 6BQ

RECRUITING

Research Site, London

OX3 7LE

RECRUITING

Research Site, Oxford