Individualized or Conventional Transfusion Strategies During Peripheral VA-ECMO

PHASE1RecruitingINTERVENTIONAL
Enrollment

238

Participants

Timeline

Start Date

September 18, 2023

Primary Completion Date

September 18, 2025

Study Completion Date

December 18, 2025

Conditions
Cardiogenic ShockExtracorporeal Membrane OxygenationTransfusion Related ComplicationAnemiaOxygen Delivery
Interventions
DRUG

Packed Red Blood Cells (PRBCs)

"Patient will recieve PRBCs transfusion only in case of ScVO2 level\<65% after assessment of patient for optimisation of SaO2 targeting 100%, volume status, ECMO flow (increase to 20% in relevant), pain, anxiety and fever (body temperature \>38°3).~In both groups transfusion may be performed in case massive bleeding according to local protocols, STEMI, Hyperlactatemia \>4 that can be related to oxygen demand and supply DO2/VO2 ratio impairement, in all groups, transfusion should be performed in case of hemolobin level \<7g/dL or worsening of neurological condition (Increase in Neurological SOFA component of 1 and more) related to DO2/VO2 impairement."

Trial Locations (1)

59000

RECRUITING

Service d'Anesthésie-Réanimation CCV Hôpital Cardiologique Centre Hospitalier et Universitaire de Lille, Lille

All Listed Sponsors
collaborator

Amiens University Hospital

OTHER

collaborator

University Hospital, Caen

OTHER

collaborator

University Hospital, Rouen

OTHER

collaborator

Centre Hospitalier Universitaire Dijon

OTHER

collaborator

Centre hospitalier de Dunkerque

UNKNOWN

collaborator

Centre Hospitalier de Lens

OTHER

lead

University Hospital, Lille

OTHER