500
Participants
Start Date
April 26, 2023
Primary Completion Date
July 31, 2026
Study Completion Date
June 30, 2027
Sodium bicarbonate
Sodium bicarbonate 8.4% will be continuously infused for a maximum of 5 hours. The infusion will start at 100 mL/hr and be kept at this rate until both pH and BE targets are achieved, following which, the infusion rate will be decreased to 25 mL/hr and kept constant at this rate until 5 hours has elapsed since the start of the infusion. At this point, the infusion will be stopped, independently, of the results of arterial blood gas analysis.
5% Dextrose
5% dextrose will be continuously infused for a maximum of 5 hours. The infusion will start at 100 mL/hr and be kept at this rate until both pH and BE targets are achieved, following which, the infusion rate will be decreased to 25 mL/hr and kept constant at this rate until 5 hours has elapsed since the start of the infusion. At this point, the infusion will be stopped, independently, of the results of arterial blood gas analysis.
RECRUITING
St Vincent's Hospital Sydney, Darlinghurst
RECRUITING
Royal Prince Alfred Hospital, Camperdown
RECRUITING
Gosford Hospital, Gosford
RECRUITING
Calvary Mater Newcastle, Waratah
RECRUITING
Canberra Hospital, Garran
RECRUITING
The Alfred Hospital, Melbourne
RECRUITING
Footscray Hospital, Footscray
RECRUITING
Sunshine Hospital, St Albans
RECRUITING
The Austin Hospital, Heidelberg
RECRUITING
Epworth, Richmond
RECRUITING
Frankston Hospital, Frankston
RECRUITING
Grapmians Health, Ballarat
RECRUITING
Casey Hospital, Berwick
RECRUITING
Peninsula Private Hospital, Langwarrin
RECRUITING
Royal Brisbane and Women's Hospital, Herston
RECRUITING
Mater Hospital, South Brisbane
RECRUITING
Princess Alexandra Hopsital, Woolloongabba
RECRUITING
Queen Elizabeth II Jubilee Hospital, Coopers Plains
RECRUITING
Christchurch Hospital, Christchurch
RECRUITING
Cairns Hospital, Cairns
RECRUITING
Royal Adelaide Hospital, Adelaide
RECRUITING
The Queen Elizabeth Hospital, Woodville
RECRUITING
Royal Darwin Hospital, Tiwi
RECRUITING
Flinders Medical Centre, Bedford Park
RECRUITING
Auckland City Hospital, Auckland
RECRUITING
Wellington Regional Hospital, Wellington
RECRUITING
Sultan Qaboos Comprehensive Cancer Care and Research Center, Seeb
Australian and New Zealand Intensive Care Research Centre
OTHER