tDCS Combined With rTMS for Negative Symptoms of Schizophrenia

NAUnknownINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

July 1, 2022

Primary Completion Date

September 1, 2024

Study Completion Date

December 30, 2024

Conditions
Schizophrenia Negative Type
Interventions
DEVICE

tDCS active stimulation combined with rTMS sham stimulation

"Active tDCS positive stimulation: left dorsolateral prefrontal cortex (DLPFC) or BeamF3 method; negative stimulation: right frontal, 2mA, 20 mins stimulation, 1 time/day, 5 consecutive days, weekend suspension, lasting 4 weeks, total 20 times.~Sham stimulation rTMS: Parameters such as stimulation site, current intensity, and stimulation time are kept consistent, keeping the coil facing outward."

DEVICE

rTMS active stimulation combined with tDCS sham stimulation

"Sham stimulation tDCS: Parameters such as stimulation site, current intensity, and stimulation time are kept consistent, keeping the switch off.~Active rTMS: stimulation site: left dorsolateral prefrontal cortex (DLPFC); consisting of a total of 3000 pulses per session at 10Hz (4 seconds on and 16 seconds off) at 110% resting motion threshold (RMT), 40 pulses per string; total 75 strings; 1 time/day, 5 consecutive days, weekend suspension, total 20 times. Resting motor thresholds (RMT) were measured before the start of each day of treatment."

DEVICE

tDCS active stimulation combined with rTMS active stimulation

"Active tDCS positive stimulation: left dorsolateral prefrontal cortex (DLPFC) or BeamF3 method; negative stimulation: right frontal, 2mA, 20 mins stimulation, 1 time/day, 5 consecutive days, weekend suspension, lasting 4 weeks, total 20 times.~Active rTMS: stimulation site: left dorsolateral prefrontal cortex (DLPFC); consisting of a total of 3000 pulses per session at 10Hz (4 seconds on and 16 seconds off) at 110% resting motion threshold (RMT), 40 pulses per string; total 75 strings; 1 time/day, 5 consecutive days, weekend suspension, total 20 times. Resting motor thresholds (RMT) were measured before the start of each day of treatment."

DEVICE

tDCS sham stimulation combined with rTMS sham stimulation

"Sham stimulation tDCS: Parameters such as stimulation site, current intensity, and stimulation time are kept consistent, keeping the switch off.~Sham stimulation rTMS: Parameters such as stimulation site, current intensity, and stimulation time are kept consistent, keeping the coil facing outward."

Trial Locations (1)

300222

Jie Li, Tianjin

Sponsors
All Listed Sponsors
collaborator

Chinese Academy of Sciences

OTHER_GOV

lead

Tianjin Anding Hospital

OTHER

NCT05695144 - tDCS Combined With rTMS for Negative Symptoms of Schizophrenia | Biotech Hunter | Biotech Hunter