Testing the Addition of Cemiplimab to Palbociclib for the Treatment of Advanced Dedifferentiated Liposarcoma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

77

Participants

Timeline

Start Date

June 7, 2023

Primary Completion Date

May 31, 2027

Study Completion Date

May 31, 2027

Conditions
Advanced Dedifferentiated LiposarcomaLocally Advanced Dedifferentiated LiposarcomaMetastatic Dedifferentiated LiposarcomaStage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC V8Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC V8Unresectable Dedifferentiated Liposarcoma
Interventions
DRUG

Palbociclib

Given PO

BIOLOGICAL

Cemiplimab

Given IV

PROCEDURE

Magnetic Resonance Imaging

undergo MRI

PROCEDURE

Computed Tomography

Undergo a CT Scan

PROCEDURE

Biospecimen collection

Undergo blood sample collection

OTHER

Questionnaire Administration

Ancillary Studies

Trial Locations (194)

14263

Roswell Park Cancer Institute, Buffalo

20010

MedStar Washington Hospital Center, Washington D.C.

23229

Virginia Cancer Institute, Richmond

23235

VCU Massey Cancer Center at Stony Point, Richmond

23298

Virginia Commonwealth University/Massey Cancer Center, Richmond

25304

West Virginia University Charleston Division, Charleston

28203

Carolinas Medical Center/Levine Cancer Institute, Charlotte

28210

Atrium Health Pineville/LCI-Pineville, Charlotte

35233

University of Alabama at Birmingham Cancer Center, Birmingham

40004

Flaget Memorial Hospital, Bardstown

40353

Saint Joseph Mount Sterling, Mount Sterling

40504

Saint Joseph Hospital, Lexington

Saint Joseph Radiation Oncology Resource Center, Lexington

40509

Saint Joseph Hospital East, Lexington

40701

Commonwealth Cancer Center-Corbin, Corbin

40741

Saint Joseph London, London

43210

Ohio State University Comprehensive Cancer Center, Columbus

44011

UH Seidman Cancer Center at UH Avon Health Center, Avon

44024

Geauga Hospital, Chardon

44106

Case Western Reserve University, Cleveland

44122

UHHS-Chagrin Highlands Medical Center, Beachwood

44129

University Hospitals Parma Medical Center, Parma

44145

UH Seidman Cancer Center at Saint John Medical Center, Westlake

44195

Cleveland Clinic Foundation, Cleveland

44870

UH Seidman Cancer Center at Firelands Regional Medical Center, Sandusky

45220

Good Samaritan Hospital - Cincinnati, Cincinnati

45242

Bethesda North Hospital, Cincinnati

45247

TriHealth Cancer Institute-Westside, Cincinnati

45255

TriHealth Cancer Institute-Anderson, Cincinnati

48038

Henry Ford Macomb Hospital-Clinton Township, Clinton Township

48126

Henry Ford Medical Center-Fairlane, Dearborn

48183

Henry Ford Cancer Institute-Downriver, Brownstown

48202

Henry Ford Hospital, Detroit

48322

Henry Ford West Bloomfield Hospital, West Bloomfield

48377

Henry Ford Medical Center-Columbus, Novi

51503

Alegent Health Mercy Hospital, Council Bluffs

Heartland Oncology and Hematology LLP, Council Bluffs

Methodist Jennie Edmundson Hospital, Council Bluffs

Nebraska Cancer Specialists/Oncology Hematology West PC - MEJ, Council Bluffs

53066

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

53149

ProHealth D N Greenwald Center, Mukwonago

53188

ProHealth Waukesha Memorial Hospital, Waukesha

UW Cancer Center at ProHealth Care, Waukesha

53226

Medical College of Wisconsin, Milwaukee

53548

Mercyhealth Hospital and Cancer Center - Janesville, Janesville

54401

Marshfield Clinic-Wausau Center, Wausau

54449

Marshfield Medical Center-Marshfield, Marshfield

54456

Marshfield Medical Center - Neillsville, Neillsville

54476

Marshfield Medical Center - Weston, Weston

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54494

Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids

54548

Marshfield Clinic-Minocqua Center, Minocqua

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

54729

Marshfield Clinic-Chippewa Center, Chippewa Falls

54848

Marshfield Medical Center - Ladysmith, Ladysmith

54868

Marshfield Medical Center-Rice Lake, Rice Lake

54911

ThedaCare Regional Cancer Center, Appleton

54981

ThedaCare Cancer Care - Waupaca, Waupaca

55905

Mayo Clinic in Rochester, Rochester

60026

NorthShore University HealthSystem-Glenbrook Hospital, Glenview

Northwestern Medicine Glenview Outpatient Center, Glenview

60030

Northwestern Medicine Grayslake Outpatient Center, Grayslake

60035

NorthShore University HealthSystem-Highland Park Hospital, Highland Park

60045

Northwestern Medicine Lake Forest Hospital, Lake Forest

60115

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60134

Northwestern Medicine Cancer Center Delnor, Geneva

60190

Northwestern Medicine Central DuPage Hospital, Winfield

60201

NorthShore University HealthSystem-Evanston Hospital, Evanston

60462

Northwestern Medicine Orland Park, Orland Park

60504

Rush - Copley Medical Center, Aurora

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60560

Rush-Copley Healthcare Center, Yorkville

60611

Northwestern University, Chicago

61021

Illinois CancerCare-Dixon, Dixon

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

Valley Radiation Oncology, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

Western Illinois Cancer Treatment Center, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

61571

Illinois CancerCare - Washington, Washington

61615

Illinois CancerCare-Peoria, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

61801

Carle Cancer Center, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

Cancer Care Center of O'Fallon, O'Fallon

HSHS Saint Elizabeth's Hospital, O'Fallon

62321

Illinois CancerCare-Carthage, Carthage

62401

Carle Physician Group-Effingham, Effingham

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Memorial Medical Center, Springfield

62801

Centralia Oncology Clinic, Centralia

62902

Memorial Hospital of Carbondale, Carbondale

62918

SIH Cancer Institute, Carterville

63080

Missouri Baptist Sullivan Hospital, Sullivan

63110

Washington University School of Medicine, St Louis

63127

BJC Outpatient Center at Sunset Hills, Sunset Hills

63129

Siteman Cancer Center-South County, St Louis

63131

Missouri Baptist Medical Center, St Louis

63640

Parkland Health Center - Farmington, Farmington

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

Saint Francis Medical Center, Cape Girardeau

Southeast Cancer Center, Cape Girardeau

65109

MU Health Care Goldschmidt Cancer Center, Jefferson City

68046

Midlands Community Hospital, Papillion

68114

Nebraska Cancer Specialists/Oncology Hematology West PC - MECC, Omaha

Nebraska Methodist Hospital, Omaha

Oncology Associates PC, Omaha

68118

Nebraska Medicine-Village Pointe, Omaha

68122

Alegent Health Immanuel Medical Center, Omaha

68123

Nebraska Medicine-Bellevue, Bellevue

68124

Alegent Health Bergan Mercy Medical Center, Omaha

68130

Alegent Health Lakeside Hospital, Omaha

68131

Creighton University Medical Center, Omaha

68198

University of Nebraska Medical Center, Omaha

68510

Saint Elizabeth Regional Medical Center, Lincoln

68847

CHI Health Good Samaritan, Kearney

73104

University of Oklahoma Health Sciences Center, Oklahoma City

77030

M D Anderson Cancer Center, Houston

80122

Littleton Adventist Hospital, Littleton

80138

Parker Adventist Hospital, Parker

80210

Porter Adventist Hospital, Denver

80228

Saint Anthony Hospital, Lakewood

80501

Longmont United Hospital, Longmont

80907

Penrose-Saint Francis Healthcare, Colorado Springs

Rocky Mountain Cancer Centers-Penrose, Colorado Springs

80923

Saint Francis Cancer Center, Colorado Springs

81004

Saint Mary Corwin Medical Center, Pueblo

81301

Mercy Medical Center, Durango

Southwest Oncology PC, Durango

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

85004

Cancer Center at Saint Joseph's, Phoenix

85054

Mayo Clinic Hospital in Arizona, Phoenix

85259

Mayo Clinic in Arizona, Scottsdale

91010

City of Hope Comprehensive Cancer Center, Duarte

93401

Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo

93420

Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande

93444

Mission Hope Medical Oncology - Santa Maria, Santa Maria

93720

Fresno Cancer Center, Fresno

Kaiser Permanente-Fresno, Fresno

94063

Kaiser Permanente- Marshall Medical Offices, Redwood City

94080

Kaiser Permanente Cancer Treatment Center, South San Francisco

Kaiser Permanente-South San Francisco, South San Francisco

94115

Kaiser Permanente-San Francisco, San Francisco

94531

Kaiser Permanente-Deer Valley Medical Center, Antioch

94538

Kaiser Permanente-Fremont, Fremont

94568

Kaiser Permanente Dublin, Dublin

94577

Kaiser Permanente San Leandro, San Leandro

94589

Kaiser Permanente-Vallejo, Vallejo

94596

Kaiser Permanente-Walnut Creek, Walnut Creek

94611

Kaiser Permanente Oakland-Broadway, Oakland

Kaiser Permanente-Oakland, Oakland

94801

Kaiser Permanente-Richmond, Richmond

94903

Kaiser San Rafael-Gallinas, San Rafael

94928

Rohnert Park Cancer Center, Rohnert Park

95051

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95119

Kaiser Permanente-Santa Teresa-San Jose, San Jose

95210

Kaiser Permanente-Stockton, Stockton

95340

Mercy Cancer Center, Merced

95356

Kaiser Permanente-Modesto, Modesto

95403

Kaiser Permanente-Santa Rosa, Santa Rosa

95608

Mercy Cancer Center - Carmichael, Carmichael

Mercy San Juan Medical Center, Carmichael

95661

Kaiser Permanente-Roseville, Roseville

95670

Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova

95678

The Permanente Medical Group-Roseville Radiation Oncology, Roseville

95688

Kaiser Permanente Medical Center-Vacaville, Vacaville

95695

Woodland Memorial Hospital, Woodland

95758

Mercy Cancer Center - Elk Grove, Elk Grove

95765

Mercy Cancer Center - Rocklin, Rocklin

95814

Kaiser Permanente Downtown Commons, Sacramento

95816

Mercy Cancer Center - Sacramento, Sacramento

95823

South Sacramento Cancer Center, Sacramento

96819

Kaiser Permanente Moanalua Medical Center, Honolulu

97239

Oregon Health and Science University, Portland

98109

Fred Hutchinson Cancer Center, Seattle

98195

University of Washington Medical Center - Montlake, Seattle

98383

Saint Michael Cancer Center, Silverdale

32224-9980

Mayo Clinic in Florida, Jacksonville

02215

Dana-Farber Cancer Institute, Boston

08822

Hunterdon Medical Center, Flemington

07601

Hackensack University Medical Center, Hackensack

07753

Jersey Shore Medical Center, Neptune City

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Alliance for Clinical Trials in Oncology

OTHER