Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

58

Participants

Timeline

Start Date

September 28, 2023

Primary Completion Date

March 1, 2027

Study Completion Date

March 1, 2027

Conditions
Advanced Malignant Solid NeoplasmAdvanced Microsatellite Stable Colorectal CarcinomaHematopoietic and Lymphatic System NeoplasmMetastatic Malignant Solid NeoplasmMetastatic Microsatellite Stable Colorectal CarcinomaStage III Colorectal Cancer AJCC v8Stage IV Colorectal Cancer AJCC v8
Interventions
PROCEDURE

Biopsy Procedure

Undergo biopsy

PROCEDURE

Biospecimen Collection

Undergo collection of blood samples

PROCEDURE

Computed Tomography

Undergo CT scan

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Temozolomide

Given orally (PO)

DRUG

Tuvusertib

Given PO

Trial Locations (23)

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

20892

RECRUITING

National Cancer Institute Developmental Therapeutics Clinic, Bethesda

37232

RECRUITING

Vanderbilt University/Ingram Cancer Center, Nashville

62269

RECRUITING

Memorial Hospital East, Shiloh

63110

RECRUITING

Washington University School of Medicine, St Louis

63129

RECRUITING

Siteman Cancer Center-South County, St Louis

63136

RECRUITING

Siteman Cancer Center at Christian Hospital, St Louis

63141

RECRUITING

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

RECRUITING

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

64064

RECRUITING

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64116

SUSPENDED

University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City

64154

RECRUITING

University of Kansas Cancer Center - North, Kansas City

66160

RECRUITING

University of Kansas Cancer Center, Kansas City

66205

RECRUITING

University of Kansas Clinical Research Center, Fairway

RECRUITING

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

RECRUITING

University of Kansas Cancer Center-Overland Park, Overland Park

66211

RECRUITING

University of Kansas Hospital-Indian Creek Campus, Overland Park

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

92093

ACTIVE_NOT_RECRUITING

UC San Diego Moores Cancer Center, La Jolla

92612

RECRUITING

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine

92868

RECRUITING

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

06520

RECRUITING

Yale University, New Haven

06611

RECRUITING

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH