Phase III, Open-label, First-line Study of Dato-DXd in Combination With Durvalumab and Carboplatin for Advanced NSCLC Without Actionable Genomic Alterations

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,350

Participants

Timeline

Start Date

December 29, 2022

Primary Completion Date

November 1, 2027

Study Completion Date

November 1, 2027

Conditions
NSCLC
Interventions
DRUG

Datopotamab deruxtecan

Intravenous (IV) infusion every 3 weeks (Q3W) on Day 1 of each 21-day cycle.

DRUG

Durvalumab

Intravenous (IV) infusion every 3 weeks (Q3W) on Day 1 of each 21-day cycle.

DRUG

Carboplatin

Intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle for up to 4 cycles.

DRUG

Pembrolizumab

Intravenous (IV) infusion every 3 weeks (Q3W) on Day 1 of each 21-day cycle for a maximum of 35 cycles or 2 years (whichever occurs first).

DRUG

Cisplatin

Intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle for up to 4 cycles.

DRUG

Pemetrexed

Intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle.

DRUG

Paclitaxel

Intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle for up to 4 cycles.

Trial Locations (255)

34

Research Site, Lima

235

Research Site, Taipei

300

Research Site, Hsinchu

333

Research Site, Taoyuan

1090

Research Site, Vienna

1113

Research Site, Sofia

1121

Research Site, Budapest

1122

Research Site, Budapest

1210

Research Site, Vienna

1330

Research Site, Sofia

2045

Research Site, Törökbálint

3200

Research Site, Gyöngyös - Mátraháza

5000

Research Site, Szolnok

6830

Research Site, Rankweil

7100

Research Site, Szekszárd

7400

Research Site, Kaposvár

7624

Research Site, Pécs

8036

Research Site, Graz

9010

Research Site, Varna

10043

Research Site, Orbassano

11217

Research Site, Taipei

11526

Research Site, Athens

11527

Research Site, Athens

12065

Research Site, Clifton Park

12125

Research Site, Concepción

14080

Research Site, México

14109

Research Site, Berlin

15036

Research Site, Lima

16247

Research Site, Suwon

16499

Research Site, Suwon

17176

Research Site, Stockholm

17403

Research Site, York

19104

Research Site, Philadelphia

19107

Research Site, Philadelphia

19111

Research Site, Philadelphia

20089

Research Site, Rozzano

20251

Research Site, Hamburg

22030

Research Site, Edirne

22031

Research Site, Fairfax

23229

Research Site, Henrico

23502

Research Site, Norfolk

23900

Research Site, Lecco

24116

Research Site, Kiel

27003

Research Site, Lugo

28041

Research Site, Madrid

28644

Research Site, Cheongju-si

28806

Research Site, Asheville

29200

Research Site, Brest

30029

Research Site, Nîmes

31059

Research Site, Toulouse

32224

Research Site, Jacksonville

32429

Research Site, Minden

33332

Research Site, Gütersloh

33401

Research Site, West Palm Beach

33705

Research Site, St. Petersburg

33812

Research Site, Lakeland

33901

Research Site, Fort Myers

34070

Research Site, Montpellier

34098

Research Site, Istanbul

34125

Research Site, Kassel

35016

Research Site, Las Palmas de Gran Canaria

35110

Research Site, Izmir

35128

Research Site, Padua

37000

Research Site, Tours

37019

Research Site, Peschiera del Garda

38120

Research Site, Memphis

39008

Research Site, Santander

40705

Research Site, Taichung

41013

Research Site, Seville

42551

Research Site, Velbert

43126

Research Site, Parma

43219

Research Site, Columbus

43537

Research Site, Maumee

44710

Research Site, Canton

46010

Research Site, Valencia

46845

Research Site, Fort Wayne

48108

Research Site, Busan

50009

Research Site, Zaragoza

50134

Research Site, Florence

50309

Research Site, Des Moines

52242

Research Site, Iowa City

52722

Research Site, Bettendorf

52727

Research Site, Jinju

54601

Research Site, La Crosse

54911

Research Site, Appleton

55236

Research Site, Thessaloniki

55805

Research Site, Duluth

55905

Research Site, Rochester

56073

Research Site, Koblenz

57001

Research Site, Thessaloniki

57201

Research Site, Watertown

60521

Research Site, Hinsdale

60590

Research Site, Frankfurt A. Main

63401

Research Site, Hannibal

67091

Research Site, Strasbourg

68506

Research Site, Lincoln

68516

Research Site, Lincoln

69400

Research Site, Gleizé

70433

Research Site, Covington

70808

Research Site, Baton Rouge

71913

Research Site, Hot Springs

72205

Research Site, Little Rock

72762

Research Site, Springdale

73657

Research Site, Tainan City

74134

Research Site, Tulsa

75018

Research Site, Paris

75063

Research Site, Irving

75246

Research Site, Dallas

75674

Research Site, Paris

76031

Research Site, Rouen

76104

Research Site, Fort Worth

77030

Research Site, Houston

77090

Research Site, Houston

78209

Research Site, San Luis Potosí City

80131

Research Site, Napoli

80303

Research Site, Boulder

82131

Research Site, Gauting

83022

Research Site, Rosenheim

83800

Research Site, Toulon

85054

Research Site, Phoenix

85704

Research Site, Tucson

90017

Research Site, Los Angeles

92708

Research Site, Fountain Valley

92868

Research Site, Orange

94010

Research Site, Créteil

97074

Research Site, Würzburg

97239

Research Site, Portland

97301

Research Site, Salem

98055

Research Site, Renton

98158

Research Site, Messina

98405

Research Site, Tacoma

99202

Research Site, Spokane

99437

Research Site, Bad Berka

100000

Research Site, Hanoi

100010

Research Site, Beijing

100029

Research Site, Beijing

100037

Research Site, Beijing

100039

Research Site, Beijing

100853

Research Site, Beijing

110004

Research Site, Shenyang

110029

Research Site, Delhi

110085

Research Site, Delhi

200030

Research Site, Shanghai

200032

Research Site, Shanghai

200080

Research Site, Shanghai

225001

Research Site, Yangzhou

230601

Research Site, Hefei

250021

Research Site, Jinan

300060

Research Site, Tianjin

302017

Research Site, Jaipur

325000

Research Site, Wenzhou

361004

Research Site, Xiamen

400037

Research Site, Chongqing

410008

Research Site, Changsha

410013

Research Site, Changsha

430030

Research Site, Wuhan

430060

Research Site, Wuhan

450052

Research Site, Zhengzhou

510000

Research Site, Guangzhou

510100

Research Site, Guangzhou

515041

Research Site, Shantou

517108

Research Site, Shenzhen

545006

Research Site, Liuzhou

605006

Research Site, Puducherry

610041

Research Site, Chengdu

610072

Research Site, Chengdu

625107

Research Site, Madurai

650101

Research Site, Kunming

673601

Research Site, Calicut

700000

Research Site, Ho Chi Minh City

700160

Research Site, Kolkata

730000

Research Site, Lanzhou

89010-340

Research Site, Blumenau

88034-000

Research Site, Florianópolis

60336-045

Research Site, Fortaleza

86015-520

Research Site, Londrina

90035-903

Research Site, Porto Alegre

01246-000

Research Site, São Paulo

01327-001

Research Site, São Paulo

01509-900

Research Site, São Paulo

09323-900

Research Site, São Paulo

12030-200

Research Site, Taubaté

29043-260

Research Site, Vitória

E2L 4L2

Research Site, Saint John

L6R 3J7

Research Site, Brampton

P3E 5J1

Research Site, Greater Sudbury

N2G 1G3

Research Site, Kitchener

L3Y 2P9

Research Site, Newmarket

H1T 2M4

Research Site, Montreal

H4A 3J1

Research Site, Montreal

H4J 1C5

Research Site, Montreal

J7Z 5T3

Research Site, Saint-Jérôme

S7N 4H4

Research Site, Saskatoon

CN-100730

Research Site, Beijing

Unknown

Research Site, Shandong

030000

Research Site, Taiyuan

02321

Research Site, Saint-Quentin

155 62

Research Site, Athens

185 47

Research Site, Piraeus

113-8603

Research Site, Bunkyō City

104-0045

Research Site, Chūōku

431-3192

Research Site, Hamamatsu

432-8580

Research Site, Hamamatsu

350-1298

Research Site, Hidaka-shi

036-8563

Research Site, Hirosaki-shi

730-8518

Research Site, Hiroshima

860-8556

Research Site, Kumamoto

464-8681

Research Site, Nagoya

466-8560

Research Site, Nagoya

700-8558

Research Site, Okayama

545-8586

Research Site, Osaka

589-8511

Research Site, Osakasayama-shi

060-8638

Research Site, Sapporo

411-8777

Research Site, Sunto-gun

641-8510

Research Site, Wakayama

221-0855

Research Site, Yokohama

241-8515

Research Site, Yokohama

06700

Research Site, Del. Cuauhtemoc

03810

Research Site, Mexico City

04002

Research Site, Arequipa

LIMA 27

Research Site, Lima

LIMA 29

Research Site, Lima

85-796

Research Site, Bydgoszcz

43-360

Research Site, Bystra

86-300

Research Site, Grudziądz

25-734

Research Site, Kielce

75-581

Research Site, Koszalin

10-357

Research Site, Olsztyn

60-569

Research Site, Poznan

37-700

Research Site, Przemyśl

47-400

Research Site, Racibórz

26-600

Research Site, Radom

08-110

Research Site, Siedlce

03080

Research Site, Seoul

03722

Research Site, Seoul

05505

Research Site, Seoul

06351

Research Site, Seoul

07061

Research Site, Seoul

801 88

Research Site, Gävle

581 85

Research Site, Linköping

221 85

Research Site, Lund

751 85

Research Site, Uppsala

01060

Research Site, Adana

06800

Research Site, Ankara

AB25 2ZN

Research Site, Aberdeen

CB2 0QQ

Research Site, Cambridge

CF14 2TL

Research Site, Cardiff

GL53 7AN

Research Site, Cheltenham

EH4 2XU

Research Site, Edinburgh

SE1 9RT

Research Site, London

W6 8RF

Research Site, London

M20 4BX

Research Site, Manchester

TS4 3BW

Research Site, Middlesbrough

NE7 7DN

Research Site, Newcastle upon Tyne

TA1 5DA

Research Site, Taunton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY