Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes

PHASE1RecruitingINTERVENTIONAL
Enrollment

43

Participants

Timeline

Start Date

July 6, 2023

Primary Completion Date

August 1, 2026

Study Completion Date

September 1, 2026

Conditions
Metastatic Malignant Solid NeoplasmUnresectable Malignant Solid Neoplasm
Interventions
PROCEDURE

Biopsy Procedure

Undergo tumor biopsy

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Diagnostic Imaging Testing

Undergo medical imaging scans

BIOLOGICAL

Novobiocin Sodium

Given PO

Trial Locations (21)

10016

RECRUITING

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

11501

RECRUITING

NYU Langone Hospital - Long Island, Mineola

20892

RECRUITING

National Cancer Institute Developmental Therapeutics Clinic, Bethesda

ACTIVE_NOT_RECRUITING

National Institutes of Health Clinical Center, Bethesda

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

53718

RECRUITING

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison

53792

RECRUITING

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

84112

RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

90033

RECRUITING

Los Angeles General Medical Center, Los Angeles

RECRUITING

USC / Norris Comprehensive Cancer Center, Los Angeles

91010

RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

92093

RECRUITING

UC San Diego Moores Cancer Center, La Jolla

92103

RECRUITING

UC San Diego Medical Center - Hillcrest, San Diego

92612

RECRUITING

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine

92868

RECRUITING

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

95817

RECRUITING

University of California Davis Comprehensive Cancer Center, Sacramento

02215

RECRUITING

Beth Israel Deaconess Medical Center, Boston

RECRUITING

Dana-Farber Cancer Institute, Boston

M5G 2M9

SUSPENDED

University Health Network-Princess Margaret Hospital, Toronto

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH