CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)

PHASE3RecruitingINTERVENTIONAL
Enrollment

800

Participants

Timeline

Start Date

December 13, 2022

Primary Completion Date

March 31, 2027

Study Completion Date

March 31, 2027

Conditions
Severe Hypertriglyceridemia
Interventions
DRUG

Olezarsen

Administered as SC injection.

Trial Locations (262)

111

RECRUITING

Shing Kong Wu Ho-Su Memorial Hospital, Taipei

424

RECRUITING

The Lipid Clinic (Oslo University Hospital), Oslo

704

RECRUITING

National Cheng Kung University Hospital, Tainan City

1000

RECRUITING

Medical Center for Specialized Medical Help in Cardiovascular Diseases OOD, Sofia

1070

RECRUITING

Universite Libre de Brussels (ULB)- Hopital Erasme, Brussels

1307

RECRUITING

Universitaetsklinikum Carl Gustav Carus, Dresden

1527

RECRUITING

UMHAT Tsaritsa Yoanna ISUL- Clinic of Cardiology, Sofia

1606

RECRUITING

Medical Center Endomedical, Sofia

1680

RECRUITING

Medical Center Kalimat EOOD, Sofia

1700

RECRUITING

MC Doctor Kalchev OOD, Sofia

1784

RECRUITING

Medical Centre Synexus Sofia, Sofia

1797

RECRUITING

UMHAT Sofiamed, Sofia

2050

RECRUITING

Royal Prince Alfred Hospital, Camperdown

2065

RECRUITING

Royal North Shore Hospital, Saint Leonards

2700

RECRUITING

MHAT- Blagoevgrad AD, Blagoevgrad

3000

RECRUITING

Universitaire Ziekenhuizen Leuven, Leuven

3168

RECRUITING

Monash Medical Centre, Clayton

3500

RECRUITING

Jessa Ziekenhuis, Hasselt

4000

RECRUITING

"SBAL Special Medic Ltd.", Plovdiv

4001

RECRUITING

UHMAT Kaspela Ltd, Plovdiv

4002

RECRUITING

University Multiprofile Hospital for Active Treatment Pulmed, Clinic of Endocrinology, Plovdiv

4032

RECRUITING

Debreceni Egyetem Klinikai Központ, Debrecen

4092

RECRUITING

Centre for Diabetes, Endocrinology and Metabolic Disease, Woodhurst

4102

RECRUITING

Dr Heart Pty Ltd, Woolloongabba

4400

RECRUITING

Multiprofile Hospital for Active Treament Pazardzhik, Cardiology Department, Pazardzhik

4405

RECRUITING

Dr. Vasas Szilard Haziorvosi Rendelo, Nyíregyháza

4700

RECRUITING

Medical Center Smolyan Clinical Research OOD, Smolyan

5000

RECRUITING

Royal Adelaide Hospital, Adelaide

5006

RECRUITING

"Medical Centre Nevromedics EOOD", Veliko Tarnovo

5300

RECRUITING

MHAT, Gabrovo

6003

RECRUITING

Clinical of Cardiology, Stara Zagora

6010

RECRUITING

Medical Center Zara-Med, Stara Zagora

6021

RECRUITING

Edgar Diabetes and Obesity Research Centre, Wellington

6300

RECRUITING

MHAT Haskovo AD, Haskovo

6400

RECRUITING

Medical Center Diamedical 2013 OOD, Dimitrovgrad

6500

RECRUITING

Lausmed Kft, Baja

6700

RECRUITING

Esbjerg Hospital, Esbjerg

7000

RECRUITING

Medical Center Rusemed EOOD, Rousse

7002

RECRUITING

UMHAT Kanev AD, Rousse

7130

RECRUITING

Medi Clinic Vergelegen, Cape Town

7500

RECRUITING

TREAD Research, Cape Town

7700

RECRUITING

University of Cape Town, Cape Town

8000

RECRUITING

Medical Center Doctor Staykov EOOD, Burgas

RECRUITING

Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz, Székesfehérvár

8011

RECRUITING

New Zealand Clinical Research, Auckland

8200

RECRUITING

Aarhus Universitet Hospital, Aarhus

8230

RECRUITING

DRC Gyógyszervizsgáló Központ Korlátolt felelősségű társaság Balatonfüred, Balatonfüred

8800

RECRUITING

DCC-1 Sliven Ltd., Sliven

RECRUITING

MHAT Silven to MMA Sofia, Sofia

RECRUITING

Viborg Regional Hospital, Viborg

8907

RECRUITING

Hospital Universitari de Bellvitge, Barcelona

9000

RECRUITING

Diagnostic Consultative Center Equita (DCC Equita), Varna

RECRUITING

Aalborg University Hospital, Aalborg

9020

RECRUITING

Specialized Hospital for Active Treatment of Cardiology, Varna

9301

RECRUITING

Latros International, Bloemfontein

10016

RECRUITING

Langone Medical Center, New York

10032

RECRUITING

Vagelos College of Physicians and Surgeons of Columbia University, New York

10990

RECRUITING

Pulau Pinang Hospital, Pulau Pinang

11501

RECRUITING

NYU Langone Health, Mineola

13005

RECRUITING

Hôpitaux de Marseille, Marseille

13353

RECRUITING

Charite- Universitaetsmedizin Berlin, Berlin

14004

RECRUITING

Hospital Universitario Reina Sofia, Córdoba

14127

RECRUITING

Orchard Park Family Practice, Orchard Park

14186

RECRUITING

Karolinska University Hospital Huddinge, Stockholm

15001

RECRUITING

Hospital Abente y Lago, A Coruña

15006

RECRUITING

Fakultni Nemocnice v Motole, Prague

15123

RECRUITING

Hygeia Hospital, Athens

19014

RECRUITING

University of Pennsylvania, Philadelphia

19800

RECRUITING

Endokrinologie Cerny Most s.r.o., Prague

20092

RECRUITING

Ospdale E. Bassini, Milan

20110

RECRUITING

Manassas Clinical Research, Manassas

20162

RECRUITING

Asst Grande Ospedale Metropolitano Niguarda, Milan

20230

RECRUITING

Centro de Investigacion Cardiometabolica S.C., Mexico City

20520

RECRUITING

Turku University Hospital, Turku

21079

RECRUITING

Chu Dijon Bourgogne, Dijon

21201

RECRUITING

University of Maryland School of Medicine, Baltimore

21204

RECRUITING

IRC Clinics, Towson

23007

RECRUITING

Hospital Universitario de Jaen, Jaén

23510

RECRUITING

York Clinical Research, Norfolk

24127

RECRUITING

Azienda Socio Sanitaria Territoriale Papa Giovanni XXII, Bergamo

25160

RECRUITING

Mackay Memorial Hospital, New Taipei City

26506

RECRUITING

WVU Heart and Vascular Institute, Morgantown

27103

RECRUITING

Lexington, Winston-Salem

27401

RECRUITING

Kenneth Hilty, Greensboro

28041

RECRUITING

Hospital Universitario 12 de Octubre, Madrid

28204

RECRUITING

The Presbyterian Hospital DBA Novant Health Heart and Vascular Institute, Charlotte

28645

RECRUITING

Clinical Trials of America, LLC, Lenoir

29010

RECRUITING

Hospital Universitario Virgen de la Victoria, Málaga

29425

RECRUITING

Medical University of South Carolina, Charleston

29566

RECRUITING

Walker Family Care, Little River

31207

RECRUITING

Scientia Investigacion Clinical Sc, Chihuahua City

31904

RECRUITING

Centricity Research, Columbus

RECRUITING

IACT Health, Columbus

33027

RECRUITING

Innovia Research Center, Inc., Miramar

33125

RECRUITING

Columbus Clinical Services, LLC, Miami

33126

RECRUITING

Finlay Medical Research, Miami

33162

RECRUITING

Harmony Clinical Research, Inc., North Miami Beach

33434

RECRUITING

Excel Medical Clinical Trials, Boca Raton

33467

RECRUITING

Finlay Medical Research, Greenacres City

33614

RECRUITING

R & B Medical Center LLC, Tampa

33615

RECRUITING

VICIS Clinical Research, Tampa

33634

RECRUITING

JSV Clinical Research Study, Inc., Tampa

33709

RECRUITING

Modern Medical, Brooklyn

34295

RECRUITING

Hopital Lapeyronie, Montpellier

34655

RECRUITING

Bayside Clinical Research, Trinity

35040

RECRUITING

Ege University School of Medicine, Department of Cardiology, Izmir

37404

RECRUITING

Chattanooga Research & Medicine, PLLC, Chattanooga

38301

RECRUITING

The Jackson Clinic, Jackson

40138

RECRUITING

Policlinico di Sant'Orsola, Bologna

40213

RECRUITING

Louisville Metabolic and Atherosclerosis Research Center (L-MARC), Louisville

40503

RECRUITING

The Research Group of Lexington, LLC, Lexington

40705

RECRUITING

Taichung Veterans General Hospital, Taichung

41009

RECRUITING

Hospital Universitario Virgen Macarena, Seville

41013

RECRUITING

Hospital Virgen del Rocío, Seville

42080

RECRUITING

Necmettin Erbakan Universitesi Meram Tip Fakultesi, Konya

43203

RECRUITING

The Ohio State University, Columbus

43204

RECRUITING

Hospital Universitari Sant Joan de Reus, Tarragona

44093

RECRUITING

CHU de Nantes - Hôpital Nord Laennec, Saint-Herblain

46010

RECRUITING

Hospital Clinico Universitario de Valencia, Valencia

46290

RECRUITING

St. Vincent Medical Group, Inc., Carmel

48109

RECRUITING

University of Michigan- Endocrinology & Metabolism, Ann Arbor

48504

RECRUITING

Aa Mrc, Llc, Flint

49387

RECRUITING

Klinikiniai Sprendimai, UAB, Kaunas

49456

RECRUITING

Saules Seimos Medicinos Centras, Kaunas

50005

RECRUITING

University Hospital Hradec Králové, Hradec Králové

50009

RECRUITING

Hospital Universitario Miguel Servet, Zaragoza

50937

RECRUITING

Universitaetsklinikum Koeln, Cologne

52621

RECRUITING

The Chaim Sheba Medical Center, Ramat Gan

57701

RECRUITING

Monument Health Clinical Research, Rapid City

57702

RECRUITING

Health Concepts, Rapid City

58455

RECRUITING

Forschungszentrum Ruhr, Witten

59100

RECRUITING

University Malaya Medical Centre (UMMC), Kuala Lumpur

59300

RECRUITING

Groupement de Cooperation Sanitaire (GCS) ESLAN - Polyclinique Vauban, Valenciennes

60523

RECRUITING

Affinity Health, Oak Brook

63110

RECRUITING

Washington School of Medicine, St Louis

66160

RECRUITING

University of Kansas Medical Center (KUMC), Kansas City

67200

RECRUITING

CHRU de Strasbourg, Strasbourg

68506

RECRUITING

Bryan Medical Center, Lincoln

69200

RECRUITING

GHM les Portes du Sud, Vénissieux

69500

RECRUITING

Louis Pradel Hospital, Bron

70852

RECRUITING

Fakultni nemocnice Ostrava, Ostrava

71111

RECRUITING

Grace Research, LLC, Bossier City

73034

RECRUITING

Central Oklahoma Early Detection Center, Edmond

74104

RECRUITING

Oklahoma Heart Institute, Tulsa

75013

RECRUITING

AP-HP Hopital Pitie-Salpetriere, Paris

75071

RECRUITING

Texas Institute of Cardiology, McKinney

75149

RECRUITING

SMS Clinical Research, LLC, Mesquite

RECRUITING

Southern Endocrinology Associates, Mesquite

75390

RECRUITING

University of Texas Southwestern, Dallas

76100

RECRUITING

Kaplan Medical Center, Rehovot

76550

RECRUITING

FMC Science, Lampasas

77030

RECRUITING

Baylor College of Medicine, Houston

77040

RECRUITING

Juno Research, Houston

77099

RECRUITING

Pioneer Research Solutions, Houston

77598

RECRUITING

Tranquil Clinical and Research Consulting Services, Webster

78028

RECRUITING

Sante Clinical Research LLC, Kerrville

78229

RECRUITING

Diabetes & Glandular Disease Clinic, P.A., San Antonio

78503

RECRUITING

DCT- McAllen Primary Care, LLC, McAllen

79761

RECRUITING

Permian Research Foundation, Odessa

80131

RECRUITING

Azienda Ospedaliera Universitaria Federico II, Napoli

80756

RECRUITING

Kaohsiung Medical University Ching-Ho Memorial Hospital, Kaohsiung City

81100

RECRUITING

"Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione Sant' Anna e San Sebastiano di Caserta", Caserta

89128

RECRUITING

Palm Research Center, Inc., Las Vegas

90057

RECRUITING

LA Universal Research Center, Inc., Los Angeles

90127

RECRUITING

Azienda Ospedaliera Universitaria Policlinico, Palmero

91131

RECRUITING

Kardiologijos ir reabilitacijos klinika, UAB, Klaipėda

91356

RECRUITING

Metabolic Institute of America, Tarzana

92161

RECRUITING

University of California, San Diego (UCSD), San Diego

97701

RECRUITING

Kardiologická ambulancia, Brezno

110060

RECRUITING

Sir Ganga Ram Hospital, New Delhi

430123

RECRUITING

Cardioplus Center SRL, Baia Mare

575003

RECRUITING

Vinaya Hospital and Research Centre, Mangalore

3104802

RECRUITING

Bnai Zion Medical Center, Haifa

3436212

RECRUITING

The Lady Davis Carmel Medical Center, Haifa

4941492

RECRUITING

Rabin Medical Center, Petah Tikva

8410101

RECRUITING

Soroka Medical Center, Beersheba

9103102

RECRUITING

Shaare Zedek Medical Center, Jerusalem

02114

RECRUITING

Massachusetts General Hospital Heart Center, Boston

07087

RECRUITING

Hudson County Clinical Trials Research Center, Union City

C1061

RECRUITING

CIPREC, Buenos Aires

C1093AAS

RECRUITING

Fundacion Favaloro, Buenos Aires

C1425AGC

RECRUITING

Centro Medico Dra. Laura Maffei-Investigacion Clinica Aplicad, Buenos Aires

C1430CKE

RECRUITING

Glenny Corp SA, Buenos Aires

X5003DCE

RECRUITING

Instituto Medico DAMIC, Córdoba

X5900JKA

RECRUITING

Clinica FUSAVIM Privada, Villa María

13010-001

RECRUITING

Centro Especializado em Cardiologia, Campinas

80730-150

RECRUITING

Nucleo de Pesquisa Clinica S/S, Curitiba

60430-270

RECRUITING

Hospital Universitario Walter Cantidio- UFC, Fortaleza

90035-903

RECRUITING

Nucleo de Pasquisa em Cirurgia Vascular, Porto Alegre

05403-000

RECRUITING

Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo- FMUSP, São Paulo

CEP-05403-000

RECRUITING

Instituto do Coracao (InCor) do Hospital das Clinicas da FMUSP, São Paulo

SP-01228-00

RECRUITING

CPQuali Pesquisa Clinica Ltda., São Paulo

N7T 4X3

RECRUITING

Bluewater Clinical Research Group, Inc., Sarnia

M3J2C5

RECRUITING

Canadian Phase Onward Inc., Toronto

G7H 7K9

RECRUITING

Ecogene-21, Chicoutimi

G1V 4W2

RECRUITING

Clinique des Maladies Lipidiques de Quebec Inc., Québec

H2W 1T7

RECRUITING

Institut de Recherches Cliniques de Montreal, Montreal

M4C 3E7

RECRUITING

Toronto General Hospital, Toronto

250 01

RECRUITING

MEDICUS SERVICES s.r.o., Brandýs nad Labem

440 01

RECRUITING

KardioBusak s.r.o., Louny

547 01

RECRUITING

EDUMED s.r.o., Náchod

128 08

RECRUITING

Vseobecna fakultni nemocnice, Prague

158 00

RECRUITING

Praha Poliklinika Hurka, Prague

261 01

RECRUITING

Milan Kvapil s.r.o., Příbram

415 01

RECRUITING

AeskuLab k.s, Teplice

686 01

RECRUITING

MU Dr. Nina Zemkova s.r.o. Interni Ambulance, Uherské Hradiště

106 76

RECRUITING

Evangelismos General Hospital Athens, Athens

H-1063

RECRUITING

Obudai Egeszsegugyyi Centrum, Budapest

H-3529

RECRUITING

Rakoczi Ferenc Korhaz, Miskolc

H-4400

RECRUITING

Kardiologia Szakrendeles, Nyíregyháza

Unknown

RECRUITING

Tel Aviv Sourasky Medical Center, Tel Aviv

00161

RECRUITING

Department of Translational and Precision Medicine, Rome

06700

RECRUITING

Clinstile, S.A. de C.V., Mexico City

1105AZ

RECRUITING

Academic Medical Center, Amsterdam

7334 DZ

RECRUITING

Gelre Ziekenhuizen, Apeldoorn

6815 AD

RECRUITING

Ziekenhuis Rijnstate, Arnhem

3247 BW

RECRUITING

Het Van Weel-Bethesda Ziekenhuis, Dirksland

1001-5000

RECRUITING

Ziekenhuis Gelderse Vallei, Ede

7909 AA

RECRUITING

Bethesda Diabetes Research Center, Hoogeveen

6525 EX

RECRUITING

Radboud UMC, Nijmegen

3015 GD

RECRUITING

Erasmus MC, Rotterdam

3584 CX

RECRUITING

University Medical Center Utrecht, Utrecht

3331 LZ

RECRUITING

Albert Schweitzer Ziekenhuis, Zwijndrecht

80-952

RECRUITING

Uniwersytecki Centrum Kliniczne, I Klinika Kardiologii, Gdansk

05-410

RECRUITING

Biokinetica Spolka Akcujna, Józefów

40-772

RECRUITING

Centrum Medyczne Salvia, Katowice

93-338

RECRUITING

Instytut Centrum Zdrowia Matki Polki, Lodz

20-078

RECRUITING

Clinical Best Solutions, Lublin

20-412

RECRUITING

ETG Lublin, Lublin

60-589

RECRUITING

Centrum Zdrowia Metabolicznego Pawel Bogdanski, Poznan

33-100

RECRUITING

Osrodek Badan Klinicznych Metabolica, Tarnów

02-793

RECRUITING

Clinical Best Solutions Sp. z.o.o. Spolka Komandytowa, Warsaw

50-088

RECRUITING

Przychodnia Futuremeds Wroclaw, Wroclaw

22-400

RECRUITING

ETG Zamosc, Zamość

3814-501

RECRUITING

Hospital Infante D. Pedro, Aveiro

1350-352

RECRUITING

Hospital COF Tejo, Lisbon

RECRUITING

Hospital CUF Tejo, Lisbon

4200-319

RECRUITING

Centro Hospitalar Universitario De Sao Joao, Porto

4520-211

RECRUITING

Centro Hospitalar de Entre o Douro e Vouga, E.P.E., Santa Maria da Feira

831 06

RECRUITING

Ambulancia diabetologicka a poruch latkovej premeny a vyzivy, Bratislava

040 22

RECRUITING

Cardio D&R, S.R.O. Kosice, Košice

04001

RECRUITING

Human-Care s.r.o., Košice

04011

RECRUITING

Vychodoslovensky Utsav srdcovych a cievnych chorob a.s., Košice

984 01

RECRUITING

Interna a diabetologicka ambulancia- IN- DRA- s.r.o., Lučenec

048 01

RECRUITING

Diab sro, Rožňava

08901

RECRUITING

Interna SK, s.r.o., Kardiologicka a interna ambulancia, Svidník

RECRUITING

Nemocnica arm. generala L. Svobodu Svidnik, a.s, Svidník

075 01

RECRUITING

Areteus sro, Trebišov

08916

RECRUITING

Hospital Germans Trias i Pujol, Badalona

08035

RECRUITING

Hospital Universitario Vall d'Hebron, Barcelona

08036

RECRUITING

Hospital Clinic De Barcelona, Barcelona

08208

RECRUITING

Corporacio Sanitaria Parc Tauli- Hospital de Sabadell, Sabadell

413 45

RECRUITING

Sahlgrenska, University Hospital, Gothenburg

06100

RECRUITING

Hacettepe Üniversitesi Tıp Fakültesi, Sulhiye

HD3 3EA

RECRUITING

Huddersfield Royal Infirmary, Huddersfield

FY4 3AD

RECRUITING

Waterloo Medical Care, Blackpool

HU3 2JZ

RECRUITING

Hull Royal Infirmiry, Hull

PL14 3XA

RECRUITING

Oak Tree Surgery and Pensilva Health Centre, Liskeard

M13 9WL

RECRUITING

Manchester University NHS Foundation Trust, Manchester

TR7 1RQ

RECRUITING

Newquay Health Centre, Newquay

BH16 5PW

RECRUITING

The Adam Practice, Poole

B71 4HU

RECRUITING

Sandwell and West Birmingham NHS Trust, West Bromwich

Sponsors
All Listed Sponsors
lead

Ionis Pharmaceuticals, Inc.

INDUSTRY